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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionineUniRule annotation1
Binding sitei81S-adenosyl-L-methionineUniRule annotation1
Binding sitei108S-adenosyl-L-methionineUniRule annotation1
Active sitei130By similarity1
Binding sitei130S-adenosyl-L-methionineUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei166SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Rxyl_2026
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882181 – 223tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST223

Proteomic databases

PRIDEiQ1AUF5

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_2026

Structurei

3D structure databases

ProteinModelPortaliQ1AUF5
SMRiQ1AUF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000033410
KOiK03439
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AUF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRKLGRMK VRPPDPETAQ RYLLRFTGRQ LYHEAERLPG LSSPELFGDQ
60 70 80 90 100
RPLELDVGCG TGEYICHLAR SDPEANFVGV DLHLKSLHKA IRRAEEANLQ
110 120 130 140 150
NIKFICADFR QMYPLLRPSA LRAVYLHFPD PGIKPRYRKR RLFNERFLEE
160 170 180 190 200
MHRAVVPGGR MSLVTDDEDY FRQMLELIER DGRWRRAHEE PYLTGFDPPV
210 220
KSRFQKMWER RGRTIYRFEL VRP
Length:223
Mass (Da):26,541
Last modified:July 11, 2006 - v1
Checksum:i91609C67B89272C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG04973.1

Genome annotation databases

EnsemblBacteriaiABG04973; ABG04973; Rxyl_2026
KEGGirxy:Rxyl_2026

Similar proteinsi

Entry informationi

Entry nameiTRMB_RUBXD
AccessioniPrimary (citable) accession number: Q1AUF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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