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Q1AUF5

- TRMB_RUBXD

UniProt

Q1AUF5 - TRMB_RUBXD

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
Active sitei130 – 1301By similarity
Binding sitei130 – 1301S-adenosyl-L-methionineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-2063-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Rxyl_2026
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223tRNA (guanine-N(7)-)-methyltransferasePRO_0000288218Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_2026.

Structurei

3D structure databases

ProteinModelPortaliQ1AUF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000033410.
KOiK03439.
OMAiMEITEAH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AUF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRRKLGRMK VRPPDPETAQ RYLLRFTGRQ LYHEAERLPG LSSPELFGDQ
60 70 80 90 100
RPLELDVGCG TGEYICHLAR SDPEANFVGV DLHLKSLHKA IRRAEEANLQ
110 120 130 140 150
NIKFICADFR QMYPLLRPSA LRAVYLHFPD PGIKPRYRKR RLFNERFLEE
160 170 180 190 200
MHRAVVPGGR MSLVTDDEDY FRQMLELIER DGRWRRAHEE PYLTGFDPPV
210 220
KSRFQKMWER RGRTIYRFEL VRP
Length:223
Mass (Da):26,541
Last modified:July 11, 2006 - v1
Checksum:i91609C67B89272C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04973.1.
RefSeqiYP_644785.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG04973; ABG04973; Rxyl_2026.
GeneIDi4115838.
KEGGirxy:Rxyl_2026.
PATRICi23370862. VBIRubXyl52678_2019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04973.1 .
RefSeqi YP_644785.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AUF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_2026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG04973 ; ABG04973 ; Rxyl_2026 .
GeneIDi 4115838.
KEGGi rxy:Rxyl_2026.
PATRICi 23370862. VBIRubXyl52678_2019.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000033410.
KOi K03439.
OMAi MEITEAH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci RXYL266117:GH8O-2063-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiTRMB_RUBXD
AccessioniPrimary (citable) accession number: Q1AUF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3