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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei206ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-2207-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Rxyl_2174
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677651 – 431Glutamate--tRNA ligase 1Add BLAST431

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_2174

Structurei

3D structure databases

ProteinModelPortaliQ1AU10
SMRiQ1AU10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi203 – 207"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AU10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSVRARFA PSPTGDLHLG GARTALFNYL FARHHGGRLL LRIEDTDRQR
60 70 80 90 100
SRREHEERIL EDLGWLGLRF DEGPYRQSER GEVYAGYAGR LLEGGLAYEA
110 120 130 140 150
EDASGRRAVY FRPPERGGAF RDALRGEVRF GGVRDFVILK SDGMPAYNFA
160 170 180 190 200
AVVDDIEMEI THVIRGEEHL PNTGRQALLY RALGVPEPEF LHLGLILGPD
210 220 230 240 250
GRKLSKRHGA QSVRGYREEG YLPEALLNYL ALLGWTHPEG REEFSGLEEL
260 270 280 290 300
VAEWDPSRLG SSPARFDPQR LLYFNARHLR RLPARRLARL VEPFLEEPLP
310 320 330 340 350
PGREEVAVEA VREELRLLSD APRLLGRLLG PVDPGAAAGR PPGGAGEALA
360 370 380 390 400
AASRLLESRR PEGLEEAREL LAALRRWAKE RGIKAREALH PLRVALTGED
410 420 430
RGPRLEYIIV LLGPEEAQKR IERAREARLR A
Length:431
Mass (Da):48,343
Last modified:July 11, 2006 - v1
Checksum:i96B19498BB294856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG05118.1
RefSeqiWP_011565132.1, NC_008148.1

Genome annotation databases

EnsemblBacteriaiABG05118; ABG05118; Rxyl_2174
KEGGirxy:Rxyl_2174

Similar proteinsi

Entry informationi

Entry nameiSYE1_RUBXD
AccessioniPrimary (citable) accession number: Q1AU10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health