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Q1ATP7 (Q1ATP7_RUBXD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Rxyl_2302
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region117 – 12595-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9215-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1211Orotate By similarity HAMAP MF_01208
Binding site1501Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q1ATP7 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 1B59CEE18059F723

FASTA17819,094
        10         20         30         40         50         60 
MEPPERRDLA ARIREASLLE GDFVLSSGRR SSFYVDKYLF STDPALLRDI AAGLEGLLPA 

        70         80         90        100        110        120 
GVERLAGVEL GAVPLVVAVA LRTGMPYVIV RKEAKGHGTV RGIEGRLGEG ERVALIEDVT 

       130        140        150        160        170 
TTGTQAVRAA RRLAEAGAEV AGVVAVLDRR EGEAGEDLQG FPFRALFRIE DLRAAKAR

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000386 Genomic DNA. Translation: ABG05231.1.
RefSeqYP_645043.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1ATP7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1ATP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4117521.
GenomeReviewsGene locus Rxyl_2302 in contig CP000386_GR.
KEGGrxy:Rxyl_2302.
NMPDRfig|266117.6.peg.2013.
PATRIC23371408. VBIRubXyl52678_2281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMAEMGGIPI.
PhylomeDBQ1ATP7.

Enzyme and pathway databases

BioCycRXYL266117:RXYL_2302-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ1ATP7_RUBXD
AccessionPrimary (citable) accession number: Q1ATP7
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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