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Q1AT41 (FOLD3_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD 3

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD3
Ordered Locus Names:Rxyl_2517
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576

Subunit structure

Homodimer By similarity. HAMAP MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Bifunctional protein FolD 3 HAMAP MF_01576
PRO_0000268487

Sequences

Sequence LengthMass (Da)Tools
Q1AT41 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 746A5C5140AD8322

FASTA31833,254
        10         20         30         40         50         60 
MGARVIDGRP IAGELKKRVA SEVEGLAARG VRPGLATVLV GEDYAARAYE RRVGGLAAEL 

        70         80         90        100        110        120 
GCRYVCERLP REAEEADVLA VVGKLNADPR VSGILVLRPL PGHISEPAVF SALDPLKDIE 

       130        140        150        160        170        180 
AVHPVNAGLL ALGRPRYVPS TPAACFYLLD RYLERSGRPP EEFYPRSTVV VVGRSNNVGK 

       190        200        210        220        230        240 
PAVSLGFARG AAVISCDANA YRAGRLREHT LKADALIVAA GVAGLIDESY VREGVIAVDV 

       250        260        270        280        290        300 
GINPVADPGG SGRTLLVGDL DFGSVARKAE ALTPVPGGVG PITDVWLLKN TVAAGRGLAS 

       310 
QAKARCLLRG SHAHSSLI

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000386 Genomic DNA. Translation: ABG05437.1.
RefSeqYP_645249.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1AT41.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1AT41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4117102.
GenomeReviewsGene locus Rxyl_2517 in contig CP000386_GR.
KEGGrxy:Rxyl_2517.
NMPDRfig|266117.6.peg.2194.
PATRIC23371818. VBIRubXyl52678_2484.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHBG328751.
OMAFHERNIF.
ProtClustDBCLSK756828.

Enzyme and pathway databases

BioCycRXYL266117:RXYL_2517-MONOMER.

Family and domain databases

HAMAPMF_01576. THF_DHG_CYH.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01491.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. False negative.
PS00767. THF_DHG_CYH_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD3_RUBXD
AccessionPrimary (citable) accession number: Q1AT41
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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