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Q1AT39

- FTHS3_RUBXD

UniProt

Q1AT39 - FTHS3_RUBXD

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Protein

Formate--tetrahydrofolate ligase 3

Gene
fhs3, Rxyl_2519
Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-2574-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 3 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 3
Short name:
FHS 3
Short name:
FTHFS 3
Gene namesi
Name:fhs3
Ordered Locus Names:Rxyl_2519
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Formate--tetrahydrofolate ligase 3UniRule annotationPRO_0000293056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_2519.

Structurei

3D structure databases

ProteinModelPortaliQ1AT39.
SMRiQ1AT39. Positions 4-571.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AT39-1 [UniParc]FASTAAdd to Basket

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MLTNLEIARG AKLLPIEEVG RSMGLREERH LEPYGRHVAK VDLCAIEDLS    50
ERPKAKYILV SAITPTPLGE GKTTTTVGLG QAFSHIGKRA TIAIRQASMG 100
PAFGIKGGAA GGGYSQVVPM ERLNLHLTGD LHAVTEAHNM LAAMIDNHLY 150
HGNGLGIEPH SISWRRVMDV NDRSLRNIVI GLGARTDGVP RQSGFDITAA 200
SEVMAILALA SSLEDLRERL GRIVIGHNRE GNPVSAEDVR GAGAMAVILK 250
EAIKPNLMQT LEGTPALVHA GPFGNIATGN SSVVADLIGI RTADYLITEA 300
GFGADMGAER FFNIKCRISG LEPDAAVVVA TVRALKAHSG RYQIKAGAPL 350
PEELLEENPQ DVLAGAENLK KQIENIKLHG VPAVVAINAF PTDHPSEHKA 400
IEEAAKEVGA RCAVCRHFTE GGKGAVELAR ALEETIEENE RERRRGGGGS 450
FRFLYPLEMP LKQKIETIAR EVYGAEGVEY DAEALRALEG FERAGFGRLP 500
VCLAKTHLSL SSDPALKGAP RGWKLSVREV RASVGAGFIY PICGQMRTMP 550
GLSAHPAAER IDLDGEGNVV GLF 573
Length:573
Mass (Da):61,311
Last modified:July 11, 2006 - v1
Checksum:iCDAE742660E99CAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG05439.1.
RefSeqiYP_645251.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG05439; ABG05439; Rxyl_2519.
GeneIDi4117104.
KEGGirxy:Rxyl_2519.
PATRICi23371822. VBIRubXyl52678_2486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG05439.1 .
RefSeqi YP_645251.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AT39.
SMRi Q1AT39. Positions 4-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_2519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG05439 ; ABG05439 ; Rxyl_2519 .
GeneIDi 4117104.
KEGGi rxy:Rxyl_2519.
PATRICi 23371822. VBIRubXyl52678_2486.

Phylogenomic databases

HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RXYL266117:GH8O-2574-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiFTHS3_RUBXD
AccessioniPrimary (citable) accession number: Q1AT39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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