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Q1AT39

- FTHS3_RUBXD

UniProt

Q1AT39 - FTHS3_RUBXD

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Protein

Formate--tetrahydrofolate ligase 3

Gene

fhs3

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-2574-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 3UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 3UniRule annotation
Short name:
FHS 3UniRule annotation
Short name:
FTHFS 3UniRule annotation
Gene namesi
Name:fhs3UniRule annotation
Ordered Locus Names:Rxyl_2519
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Formate--tetrahydrofolate ligase 3PRO_0000293056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_2519.

Structurei

3D structure databases

ProteinModelPortaliQ1AT39.
SMRiQ1AT39. Positions 4-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AT39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTNLEIARG AKLLPIEEVG RSMGLREERH LEPYGRHVAK VDLCAIEDLS
60 70 80 90 100
ERPKAKYILV SAITPTPLGE GKTTTTVGLG QAFSHIGKRA TIAIRQASMG
110 120 130 140 150
PAFGIKGGAA GGGYSQVVPM ERLNLHLTGD LHAVTEAHNM LAAMIDNHLY
160 170 180 190 200
HGNGLGIEPH SISWRRVMDV NDRSLRNIVI GLGARTDGVP RQSGFDITAA
210 220 230 240 250
SEVMAILALA SSLEDLRERL GRIVIGHNRE GNPVSAEDVR GAGAMAVILK
260 270 280 290 300
EAIKPNLMQT LEGTPALVHA GPFGNIATGN SSVVADLIGI RTADYLITEA
310 320 330 340 350
GFGADMGAER FFNIKCRISG LEPDAAVVVA TVRALKAHSG RYQIKAGAPL
360 370 380 390 400
PEELLEENPQ DVLAGAENLK KQIENIKLHG VPAVVAINAF PTDHPSEHKA
410 420 430 440 450
IEEAAKEVGA RCAVCRHFTE GGKGAVELAR ALEETIEENE RERRRGGGGS
460 470 480 490 500
FRFLYPLEMP LKQKIETIAR EVYGAEGVEY DAEALRALEG FERAGFGRLP
510 520 530 540 550
VCLAKTHLSL SSDPALKGAP RGWKLSVREV RASVGAGFIY PICGQMRTMP
560 570
GLSAHPAAER IDLDGEGNVV GLF
Length:573
Mass (Da):61,311
Last modified:July 11, 2006 - v1
Checksum:iCDAE742660E99CAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG05439.1.
RefSeqiWP_011565449.1. NC_008148.1.
YP_645251.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG05439; ABG05439; Rxyl_2519.
GeneIDi4117104.
KEGGirxy:Rxyl_2519.
PATRICi23371822. VBIRubXyl52678_2486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG05439.1 .
RefSeqi WP_011565449.1. NC_008148.1.
YP_645251.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AT39.
SMRi Q1AT39. Positions 4-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_2519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG05439 ; ABG05439 ; Rxyl_2519 .
GeneIDi 4117104.
KEGGi rxy:Rxyl_2519.
PATRICi 23371822. VBIRubXyl52678_2486.

Phylogenomic databases

HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RXYL266117:GH8O-2574-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiFTHS3_RUBXD
AccessioniPrimary (citable) accession number: Q1AT39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3