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Q1AT39

- FTHS3_RUBXD

UniProt

Q1AT39 - FTHS3_RUBXD

Protein

Formate--tetrahydrofolate ligase 3

Gene

fhs3

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRXYL266117:GH8O-2574-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 3UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 3UniRule annotation
    Short name:
    FHS 3UniRule annotation
    Short name:
    FTHFS 3UniRule annotation
    Gene namesi
    Name:fhs3UniRule annotation
    Ordered Locus Names:Rxyl_2519
    OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
    Taxonomic identifieri266117 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
    ProteomesiUP000006637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Formate--tetrahydrofolate ligase 3PRO_0000293056Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266117.Rxyl_2519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1AT39.
    SMRiQ1AT39. Positions 4-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1AT39-1 [UniParc]FASTAAdd to Basket

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    MLTNLEIARG AKLLPIEEVG RSMGLREERH LEPYGRHVAK VDLCAIEDLS    50
    ERPKAKYILV SAITPTPLGE GKTTTTVGLG QAFSHIGKRA TIAIRQASMG 100
    PAFGIKGGAA GGGYSQVVPM ERLNLHLTGD LHAVTEAHNM LAAMIDNHLY 150
    HGNGLGIEPH SISWRRVMDV NDRSLRNIVI GLGARTDGVP RQSGFDITAA 200
    SEVMAILALA SSLEDLRERL GRIVIGHNRE GNPVSAEDVR GAGAMAVILK 250
    EAIKPNLMQT LEGTPALVHA GPFGNIATGN SSVVADLIGI RTADYLITEA 300
    GFGADMGAER FFNIKCRISG LEPDAAVVVA TVRALKAHSG RYQIKAGAPL 350
    PEELLEENPQ DVLAGAENLK KQIENIKLHG VPAVVAINAF PTDHPSEHKA 400
    IEEAAKEVGA RCAVCRHFTE GGKGAVELAR ALEETIEENE RERRRGGGGS 450
    FRFLYPLEMP LKQKIETIAR EVYGAEGVEY DAEALRALEG FERAGFGRLP 500
    VCLAKTHLSL SSDPALKGAP RGWKLSVREV RASVGAGFIY PICGQMRTMP 550
    GLSAHPAAER IDLDGEGNVV GLF 573
    Length:573
    Mass (Da):61,311
    Last modified:July 11, 2006 - v1
    Checksum:iCDAE742660E99CAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG05439.1.
    RefSeqiYP_645251.1. NC_008148.1.

    Genome annotation databases

    EnsemblBacteriaiABG05439; ABG05439; Rxyl_2519.
    GeneIDi4117104.
    KEGGirxy:Rxyl_2519.
    PATRICi23371822. VBIRubXyl52678_2486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG05439.1 .
    RefSeqi YP_645251.1. NC_008148.1.

    3D structure databases

    ProteinModelPortali Q1AT39.
    SMRi Q1AT39. Positions 4-571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266117.Rxyl_2519.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG05439 ; ABG05439 ; Rxyl_2519 .
    GeneIDi 4117104.
    KEGGi rxy:Rxyl_2519.
    PATRICi 23371822. VBIRubXyl52678_2486.

    Phylogenomic databases

    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RXYL266117:GH8O-2574-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9941 / NBRC 16129.

    Entry informationi

    Entry nameiFTHS3_RUBXD
    AccessioniPrimary (citable) accession number: Q1AT39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3