Reviewed, UniProtKB/Swiss-Prot Q1AT39 (FTHS3_RUBXD)

Names and origin

Protein names

Recommended name:
    Formate--tetrahydrofolate ligase 3
    EC=6.3.4.3
Alternative name(s):
    Formyltetrahydrofolate synthetase 3
      Short name=FHS 3
      Short name=FTHFS 3

Gene names

Name:	fhs3
Ordered Locus Names:	Rxyl_2519

Organism

Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]

Taxonomic identifier

266117 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Formate--tetrahydrofolate ligase 3 HAMAP MF_01543		PRO_0000293056
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1AT39-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: CDAE742660E99CAF	FASTA	573	61,311
	10 20 30 40 50 60 MLTNLEIARG AKLLPIEEVG RSMGLREERH LEPYGRHVAK VDLCAIEDLS ERPKAKYILV 70 80 90 100 110 120 SAITPTPLGE GKTTTTVGLG QAFSHIGKRA TIAIRQASMG PAFGIKGGAA GGGYSQVVPM 130 140 150 160 170 180 ERLNLHLTGD LHAVTEAHNM LAAMIDNHLY HGNGLGIEPH SISWRRVMDV NDRSLRNIVI 190 200 210 220 230 240 GLGARTDGVP RQSGFDITAA SEVMAILALA SSLEDLRERL GRIVIGHNRE GNPVSAEDVR 250 260 270 280 290 300 GAGAMAVILK EAIKPNLMQT LEGTPALVHA GPFGNIATGN SSVVADLIGI RTADYLITEA 310 320 330 340 350 360 GFGADMGAER FFNIKCRISG LEPDAAVVVA TVRALKAHSG RYQIKAGAPL PEELLEENPQ 370 380 390 400 410 420 DVLAGAENLK KQIENIKLHG VPAVVAINAF PTDHPSEHKA IEEAAKEVGA RCAVCRHFTE 430 440 450 460 470 480 GGKGAVELAR ALEETIEENE RERRRGGGGS FRFLYPLEMP LKQKIETIAR EVYGAEGVEY 490 500 510 520 530 540 DAEALRALEG FERAGFGRLP VCLAKTHLSL SSDPALKGAP RGWKLSVREV RASVGAGFIY 550 560 570 PICGQMRTMP GLSAHPAAER IDLDGEGNVV GLF

References

[1]

"Complete sequence of Rubrobacter xylanophilus DSM 9941." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000386 Genomic DNA. Translation: ABG05439.1.
RefSeq	YP_645251.1.
3D structure databases
SMR	Q1AT39. Positions 4-571.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1AT39.
Genome annotation databases
GeneID	4117104.
GenomeReviews	Gene locus Rxyl_2519 in contig CP000386_GR.
KEGG	rxy:Rxyl_2519.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
PhylomeDB	Q1AT39.
Enzyme and pathway databases
BioCyc	RXYL266117:RXYL_2519-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS3_RUBXD

Accession

Primary (citable) accession number: Q1AT39

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 11, 2006
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)