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Q1ASC4 (THIM_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Rxyl_2790
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336570

Sites

Binding site421Substrate; via amide nitrogen By similarity
Binding site1181ATP By similarity
Binding site1621ATP By similarity
Binding site1891Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1ASC4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 297B4AFEF0C91995

FASTA26726,358
        10         20         30         40         50         60 
MRAGEALRRL GERRPLVHHI TNYVSVGLVA NATLCTGALP VMAHAREEVA EMSGAAGALV 

        70         80         90        100        110        120 
LNIGTLDERQ VESMLAAGRA ANERGIPVIL DPVGAGATAL RTRTAGRLLS ELEVSAVCGN 

       130        140        150        160        170        180 
AGEIATLAGL AAEVRGVESI GGDAREAALK AASSLGLTVA ATGAVDYVCG GGRALAVENG 

       190        200        210        220        230        240 
HPLLGRVVGS GCASTAVVGC FAAAAGSADP ETVAHALAYF GCAGEEAARG AGGPGTFEAR 

       250        260 
LLDALAALSS DPSRLSGRLR VGDAGAG 

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000386 Genomic DNA. Translation: ABG05704.1.
RefSeqYP_645516.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1ASC4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266117.Rxyl_2790.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG05704; ABG05704; Rxyl_2790.
GeneID4117623.
KEGGrxy:Rxyl_2790.
PATRIC23372378. VBIRubXyl52678_2761.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycRXYL266117:GH8O-2849-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_RUBXD
AccessionPrimary (citable) accession number: Q1ASC4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways