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Q1AS71

- ALLB_RUBXD

UniProt

Q1AS71 - ALLB_RUBXD

Protein

Allantoinase

Gene

allB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Zinc 1UniRule annotation
    Metal bindingi62 – 621Zinc 1UniRule annotation
    Metal bindingi147 – 1471Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi147 – 1471Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi183 – 1831Zinc 2UniRule annotation
    Metal bindingi239 – 2391Zinc 2UniRule annotation
    Metal bindingi312 – 3121Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. dihydroorotase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW
    3. pyrimidine nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciRXYL266117:GH8O-2905-MONOMER.
    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Ordered Locus Names:Rxyl_2845
    OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
    Taxonomic identifieri266117 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
    ProteomesiUP000006637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454AllantoinasePRO_0000317681Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266117.Rxyl_2845.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1AS71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    HOGENOMiHOG000219146.
    KOiK01466.
    OMAiCSPWEGH.
    OrthoDBiEOG6KHFW6.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR004722. DHOase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.
    TIGR00857. pyrC_multi. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1AS71-1 [UniParc]FASTAAdd to Basket

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    MSAFDLIVRG GTVVRGGCEV ADVGVADGVI SAVGPDLEGG AREEIDARGL    50
    LVLPGAIDAH VHFNEPGRTR WEGFASGTRA LAAGGTTLCV EMPLNAHPPT 100
    TDGESFDLKL AAAKASAHVD FALWGGIVPG RVGRMEELAG RGVAGFKAFM 150
    SATGTPDFEA ADDLTLYEGM QEAARLGLPV LVHAENRQIT DALARRATSA 200
    LRTTMRDYLA SRPAVAELEA IGRAILLASE AGCSLHIVHV STGRGVALVA 250
    AARERGVDVT CETCPHYLLF TDEDAVRIGA AAKCAPPLRP REEVESLWEQ 300
    VLAGNVAFVT SDHSPCPPDM KAGEDMFRAW GGISGCQSLL PALLDEGYHG 350
    RGLPPERLAE LLSANVARRF GFAGKGGIEE GNDADLALVD PSGEHVLREE 400
    DLHYRHPISP YVGRSFRGRV VRTILRGRTV FEGGRVVSGP AGRFVRPQRE 450
    KGER 454
    Length:454
    Mass (Da):48,161
    Last modified:July 11, 2006 - v1
    Checksum:i49772AD22B3E7307
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG05757.1.
    RefSeqiWP_011565766.1. NC_008148.1.
    YP_645569.1. NC_008148.1.

    Genome annotation databases

    EnsemblBacteriaiABG05757; ABG05757; Rxyl_2845.
    GeneIDi4115822.
    KEGGirxy:Rxyl_2845.
    PATRICi23372490. VBIRubXyl52678_2817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG05757.1 .
    RefSeqi WP_011565766.1. NC_008148.1.
    YP_645569.1. NC_008148.1.

    3D structure databases

    ProteinModelPortali Q1AS71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266117.Rxyl_2845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG05757 ; ABG05757 ; Rxyl_2845 .
    GeneIDi 4115822.
    KEGGi rxy:Rxyl_2845.
    PATRICi 23372490. VBIRubXyl52678_2817.

    Phylogenomic databases

    eggNOGi COG0044.
    HOGENOMi HOG000219146.
    KOi K01466.
    OMAi CSPWEGH.
    OrthoDBi EOG6KHFW6.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .
    BioCyci RXYL266117:GH8O-2905-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR004722. DHOase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    TIGR00857. pyrC_multi. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9941 / NBRC 16129.

    Entry informationi

    Entry nameiALLB_RUBXD
    AccessioniPrimary (citable) accession number: Q1AS71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3