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Protein

Allantoinase

Gene

allB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc 1UniRule annotation
Metal bindingi62 – 621Zinc 1UniRule annotation
Metal bindingi147 – 1471Zinc 1; via carbamate groupUniRule annotation
Metal bindingi147 – 1471Zinc 2; via carbamate groupUniRule annotation
Metal bindingi183 – 1831Zinc 2UniRule annotation
Metal bindingi239 – 2391Zinc 2UniRule annotation
Metal bindingi312 – 3121Zinc 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-2905-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Ordered Locus Names:Rxyl_2845
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454AllantoinasePRO_0000317681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_2845.

Structurei

3D structure databases

ProteinModelPortaliQ1AS71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1AS71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFDLIVRG GTVVRGGCEV ADVGVADGVI SAVGPDLEGG AREEIDARGL
60 70 80 90 100
LVLPGAIDAH VHFNEPGRTR WEGFASGTRA LAAGGTTLCV EMPLNAHPPT
110 120 130 140 150
TDGESFDLKL AAAKASAHVD FALWGGIVPG RVGRMEELAG RGVAGFKAFM
160 170 180 190 200
SATGTPDFEA ADDLTLYEGM QEAARLGLPV LVHAENRQIT DALARRATSA
210 220 230 240 250
LRTTMRDYLA SRPAVAELEA IGRAILLASE AGCSLHIVHV STGRGVALVA
260 270 280 290 300
AARERGVDVT CETCPHYLLF TDEDAVRIGA AAKCAPPLRP REEVESLWEQ
310 320 330 340 350
VLAGNVAFVT SDHSPCPPDM KAGEDMFRAW GGISGCQSLL PALLDEGYHG
360 370 380 390 400
RGLPPERLAE LLSANVARRF GFAGKGGIEE GNDADLALVD PSGEHVLREE
410 420 430 440 450
DLHYRHPISP YVGRSFRGRV VRTILRGRTV FEGGRVVSGP AGRFVRPQRE

KGER
Length:454
Mass (Da):48,161
Last modified:July 11, 2006 - v1
Checksum:i49772AD22B3E7307
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG05757.1.
RefSeqiWP_011565766.1. NC_008148.1.
YP_645569.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG05757; ABG05757; Rxyl_2845.
KEGGirxy:Rxyl_2845.
PATRICi23372490. VBIRubXyl52678_2817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG05757.1.
RefSeqiWP_011565766.1. NC_008148.1.
YP_645569.1. NC_008148.1.

3D structure databases

ProteinModelPortaliQ1AS71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266117.Rxyl_2845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG05757; ABG05757; Rxyl_2845.
KEGGirxy:Rxyl_2845.
PATRICi23372490. VBIRubXyl52678_2817.

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.
BioCyciRXYL266117:GH8O-2905-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiALLB_RUBXD
AccessioniPrimary (citable) accession number: Q1AS71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2006
Last modified: May 27, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.