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Q1AS35

- ASSY_RUBXD

UniProt

Q1AS35 - ASSY_RUBXD

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Protein
Argininosuccinate synthase
Gene
argG, Rxyl_2882
Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Citrulline By similarity
Binding sitei117 – 1171ATP; via amide nitrogen By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei175 – 1751Citrulline By similarity
Binding sitei184 – 1841Citrulline By similarity
Binding sitei260 – 2601Citrulline By similarity
Binding sitei272 – 2721Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-2944-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Rxyl_2882
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Argininosuccinate synthaseUniRule annotation
PRO_0000263967Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_2882.

Structurei

3D structure databases

ProteinModelPortaliQ1AS35.
SMRiQ1AS35. Positions 6-396.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AS35-1 [UniParc]FASTAAdd to Basket

« Hide

MLGGKKVVLA YSGGLDTSVC LKWFEEQGAE PYALYLDLGQ GEPAEDVREK    50
ALRIGAREVF VWDAREEFAR DYVAPAIKAN ALYGGRYPLF TALGRPLIAK 100
KLVEAARRVG ATHIAHGSTG KGNDQVRFDV TTGSLAPDLT VVAPVRDWNM 150
NRPEEIEYAR KHGIPVPVTK ESPYSVDQNL WGRSIEAGPL EDPEHEPTPD 200
VFELTAEPEE APDEPRYVEI GFERGLPTSL DGEKLPLVEL IDRLNAIAGE 250
HGVGRVDMIE DRLVGIKSRE IYEAPAALVI IQAHRELESL TLTKDVLRFK 300
PAVEQRFAEL TYDGLWFTPL KSALDAFVEE TQRTVTGSVR LKLYKGSSTV 350
AGRSAPRALY SKDLATYDPE STFDESAAAG FIALWGLPAR RWATVNPDPS 400
QAPQPASRR 409
Length:409
Mass (Da):45,122
Last modified:July 11, 2006 - v1
Checksum:iEC50D5FAB9EFF111
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG05793.1.
RefSeqiYP_645605.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG05793; ABG05793; Rxyl_2882.
GeneIDi4117343.
KEGGirxy:Rxyl_2882.
PATRICi23372568. VBIRubXyl52678_2854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG05793.1 .
RefSeqi YP_645605.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AS35.
SMRi Q1AS35. Positions 6-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_2882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG05793 ; ABG05793 ; Rxyl_2882 .
GeneIDi 4117343.
KEGGi rxy:Rxyl_2882.
PATRICi 23372568. VBIRubXyl52678_2854.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci RXYL266117:GH8O-2944-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiASSY_RUBXD
AccessioniPrimary (citable) accession number: Q1AS35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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