Q1AS30 (ARGB_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Rxyl_2887

Organism

Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]

Taxonomic identifier

266117 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000264752
Regions
	Region	37 – 38	2	Substrate binding By similarity
Sites
	Binding site	59	1	Substrate By similarity
	Binding site	149	1	Substrate By similarity
	Site	7	1	Transition state stabilizer By similarity
	Site	208	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1AS30 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: E23F1DD4AEC3C361	FASTA	253	25,189
	10 20 30 40 50 60 MRTVVVKVGG ASVAGGALED LPGVVSGGAR VAVVHGGGRQ LTRMLDSLGV PTSFREGLRV 70 80 90 100 110 120 TDERTLEVAE MVFAGSVNKQ LARGLLALGV PAAGVSGTDG PVLRVEPVPG LGRVGRVVAV 130 140 150 160 170 180 ETRLLETLWG GGFVPVVAPL GLGPRGAYNV NADDAAAALA VALGAGELLL LTDVDGLLRD 190 200 210 220 230 240 DEPVPALTPA ECERYVSSGV ASGGMAPKLR AAAEAARGGV PARIINGGRR GALAGALAGG 250 QVGTLVRQEG AFA

References

[1]

"Complete sequence of Rubrobacter xylanophilus DSM 9941." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000386 Genomic DNA. Translation: ABG05798.1.
RefSeq	YP_645610.1. NC_008148.1.
3D structure databases
ProteinModelPortal	Q1AS30.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1AS30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4117348.
GenomeReviews	Gene locus Rxyl_2887 in contig CP000386_GR.
KEGG	rxy:Rxyl_2887.
NMPDR	fig|266117.6.peg.2526.
PATRIC	23372578. VBIRubXyl52678_2859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
Enzyme and pathway databases
BioCyc	RXYL266117:RXYL_2887-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_RUBXD

Accession

Primary (citable) accession number: Q1AS30

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program