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Q1AR71 (SYL_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Rxyl_3202
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter

Protein attributes

Sequence length817 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 817817Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334808

Regions

Motif51 – 6111"HIGH" region HAMAP-Rule MF_00049
Motif588 – 5925"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5911ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1AR71 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: FDE42442A52BC7CD

FASTA81793,833
        10         20         30         40         50         60 
MSETFAKRAS RRGYDPRAIE ERWQRRWAET GLYKTDEDPS KPKHYALTML PYPSGDLHVG 

        70         80         90        100        110        120 
HWYAMTPSDT RARFMRMRGY RVFFPIGFDA FGLPAENAAI KRGIHPRDWT YSNIERMRGQ 

       130        140        150        160        170        180 
LRQMGTMFDF DAEVVTCDPE YYRWNQWFFL KFYEKGLAYR EKAPVDWCPS CNTTLAREQV 

       190        200        210        220        230        240 
VGPDRRCERC DTPVIKRNLA QWLFKITDYA EELLDFSEIE WPERVKALQR NWIGRSEGAE 

       250        260        270        280        290        300 
IEFEIEGYGG VTVFTTRPDT LFGATFFVVA PEHPAVESIT TPERGEEVRA YVERAARMSE 

       310        320        330        340        350        360 
IDRADVTREK TGVFTGAYAV NPANGERIPV YVADYVLMGY GTGAIMAVPA HDERDFEFAK 

       370        380        390        400        410        420 
KHGIEIRTVI APPDWDGSPL ERAYVGEGQM VNSGPFDGTP SAEGREKVTG WLRERGVGRP 

       430        440        450        460        470        480 
AVNYRLRDWL ISRQRYWGTP IPIVYCERCG TVPVPEEDLP VLLPEDAEFM PTGESPLKFN 

       490        500        510        520        530        540 
DEFRKTECPR CGGPAERETD TMDTFVDSSW YQYRYLSPHY EEGPFDPERG SRWLPVDQYT 

       550        560        570        580        590        600 
GGIEHATMHL LYTRFFTKVM RDLGLVDFDE PMLRLFNQGV ILGPDGNRMS KSRGNVVNPQ 

       610        620        630        640        650        660 
EYVDRYGSDV LRCYLMFIGP WDEGGPWDPG GIEGVARWLR RAFTLVAGGD VSEAEADPGE 

       670        680        690        700        710        720 
LSRRTHRLVK RVTEYLEGFR FNTAIAALME HTNYLLAVKG EVGEEEWREA MRSFLLVLAP 

       730        740        750        760        770        780 
FAPHHAEEMW EILGEEYSVH EQGWPSWDEE LVREETVTLV VQVNGKLRDR VEAPAGVDEG 

       790        800        810 
RARELALSSE RVRAHVEGRE LRKTVYVPGR LINLVVS 

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000386 Genomic DNA. Translation: ABG06107.1.
RefSeqYP_645919.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1AR71.
SMRQ1AR71. Positions 13-752.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266117.Rxyl_3202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG06107; ABG06107; Rxyl_3202.
GeneID4114999.
KEGGrxy:Rxyl_3202.
PATRIC23373196. VBIRubXyl52678_3168.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycRXYL266117:GH8O-3266-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_RUBXD
AccessionPrimary (citable) accession number: Q1AR71
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries