Reviewed, UniProtKB/Swiss-Prot Q1ACE4 (NU1C_CHAVU)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Chara vulgaris (Common stonewort)

Taxonomic identifier

55564 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Charophyceae › Charales › Characeae › Chara

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000275576
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	65 – 85	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	166 – 186	21	Potential
	Transmembrane	251 – 271	21	Potential
	Transmembrane	272 – 292	21	Potential
	Transmembrane	310 – 330	21	Potential
	Transmembrane	353 – 373	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1ACE4-1 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: 6C73666248AC5A5F	FASTA	376	41,829
	10 20 30 40 50 60 MSSLVRLKFN AIKLVIDFGI SENIAYLISI FLPIVLLLVI SVLGVLVTVW LERKISAAVQ 70 80 90 100 110 120 QRIGPEYAGS LGIMQAIVDG VKLLIKEDII PAQGDRWLFS IGPVLVVTPV ILSYLVVPFG 130 140 150 160 170 180 KNIILSDIRL GIFFWIVISS ITPLGLLIAG YASNNKYSLL GGLRAAAQSI SYEIPLTLCV 190 200 210 220 230 240 LSISLLSNTL STSDIVEQQC KYGILSWNIW RQPVGFITFF IASLAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYS GIKFGIFYVA SYLNLLVSSL FAVVLYLGGW NFPIPTTLIF FISMYKVSLP 310 320 330 340 350 360 LDSSNLLLEL IIPIIHISIT LAKTYLFIFF AILARWTLPR IRIDQLLDLG WKFLLPMAVG 370 NLLLTASFQL TLFEFS

References

[1]	"The chloroplast genome sequence of Chara vulgaris sheds new light into the closest green algal relatives of land plants." Turmel M., Otis C., Lemieux C. Mol. Biol. Evol. 23:1324-1338(2006) [PubMed: 16611644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ229107 Genomic DNA. Translation: ABA61915.1. Different initiation.
RefSeq	YP_635803.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4100285.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_CHAVU

Accession

Primary (citable) accession number: Q1ACE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)