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Protein

IQ domain-containing protein J

Gene

IQCJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein J
Gene namesi
Name:IQCJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:32406. IQCJ.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485504.

Polymorphism and mutation databases

BioMutaiIQCJ.
DMDMi121940648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159IQ domain-containing protein JPRO_0000315661Add
BLAST

Proteomic databases

PaxDbiQ1A5X6.
PRIDEiQ1A5X6.

PTM databases

iPTMnetiQ1A5X6.
PhosphoSiteiQ1A5X6.

Expressioni

Gene expression databases

BgeeiQ1A5X6.
CleanExiHS_IQCJ.

Organism-specific databases

HPAiHPA052835.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000402153.

Structurei

3D structure databases

ProteinModelPortaliQ1A5X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 6721IQAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.Curated

Phylogenomic databases

eggNOGiENOG410J0SC. Eukaryota.
ENOG410YSGH. LUCA.
GeneTreeiENSGT00390000000847.
HOGENOMiHOG000082511.
HOVERGENiHBG106631.
InParanoidiQ1A5X6.
OMAiLIIQRAW.
OrthoDBiEOG7DNNXW.
PhylomeDBiQ1A5X6.
TreeFamiTF336256.

Family and domain databases

InterProiIPR029362. IQCJ-SCHIP1.
[Graphical view]
PfamiPF15157. IQCJ-SCHIP1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1A5X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV
60 70 80 90 100
KIIQRAWREY LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPFAR
110 120 130 140 150
APVGKIHPYI SWRLQSPGDK LPGGRKVILL YLDQLARPTG FIHTLKEPQI

ERLGFLTLQ
Length:159
Mass (Da):18,226
Last modified:July 11, 2006 - v1
Checksum:i5EBF23B8E2161D3D
GO
Isoform 2 (identifier: Q1A5X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-159: FARAPVGKIH...IERLGFLTLQ → VSVMFLFLCPDLTFN

Show »
Length:112
Mass (Da):12,920
Checksum:i9CB68D585A4920F4
GO
Isoform 3 (identifier: Q1A5X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-52: Missing.

Note: No experimental confirmation available.
Show »
Length:132
Mass (Da):15,107
Checksum:i2267A67EA99D93A3
GO
Isoform 5 (identifier: Q9P0W5-5) [UniParc]FASTAAdd to basket

Also known as: IQCJ-SCHIP1 variant 1

The sequence of this isoform can be found in the external entry Q9P0W5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Length:563
Mass (Da):62,248
GO
Isoform 6 (identifier: Q9P0W5-6) [UniParc]FASTAAdd to basket

Also known as: IQCJ-SCHIP1 variant 2

The sequence of this isoform can be found in the external entry Q9P0W5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Length:536
Mass (Da):59,129
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 5227Missing in isoform 3. 1 PublicationVSP_043259Add
BLAST
Alternative sequencei98 – 15962FARAP…FLTLQ → VSVMFLFLCPDLTFN in isoform 2. 1 PublicationVSP_030597Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309553 mRNA. Translation: ABC26018.1.
DQ309554 mRNA. Translation: ABC26019.1.
AC092997 Genomic DNA. No translation available.
AC092999 Genomic DNA. No translation available.
AC107312 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78670.1.
BC137464 mRNA. Translation: AAI37465.1.
BC137469 mRNA. Translation: AAI37470.1.
BC144658 mRNA. Translation: AAI44659.1.
CCDSiCCDS46946.1. [Q1A5X6-1]
CCDS46947.1. [Q1A5X6-2]
CCDS56290.1. [Q1A5X6-3]
RefSeqiNP_001036170.1. NM_001042705.2. [Q1A5X6-1]
NP_001036171.1. NM_001042706.2. [Q1A5X6-2]
NP_001184029.1. NM_001197100.1. [Q1A5X6-3]
UniGeneiHs.570685.

Genome annotation databases

EnsembliENST00000397832; ENSP00000380932; ENSG00000214216. [Q1A5X6-2]
ENST00000451172; ENSP00000402153; ENSG00000214216. [Q1A5X6-1]
ENST00000482126; ENSP00000418141; ENSG00000214216. [Q1A5X6-3]
GeneIDi654502.
KEGGihsa:654502.
UCSCiuc003fco.4. human. [Q1A5X6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309553 mRNA. Translation: ABC26018.1.
DQ309554 mRNA. Translation: ABC26019.1.
AC092997 Genomic DNA. No translation available.
AC092999 Genomic DNA. No translation available.
AC107312 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78670.1.
BC137464 mRNA. Translation: AAI37465.1.
BC137469 mRNA. Translation: AAI37470.1.
BC144658 mRNA. Translation: AAI44659.1.
CCDSiCCDS46946.1. [Q1A5X6-1]
CCDS46947.1. [Q1A5X6-2]
CCDS56290.1. [Q1A5X6-3]
RefSeqiNP_001036170.1. NM_001042705.2. [Q1A5X6-1]
NP_001036171.1. NM_001042706.2. [Q1A5X6-2]
NP_001184029.1. NM_001197100.1. [Q1A5X6-3]
UniGeneiHs.570685.

3D structure databases

ProteinModelPortaliQ1A5X6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000402153.

PTM databases

iPTMnetiQ1A5X6.
PhosphoSiteiQ1A5X6.

Polymorphism and mutation databases

BioMutaiIQCJ.
DMDMi121940648.

Proteomic databases

PaxDbiQ1A5X6.
PRIDEiQ1A5X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397832; ENSP00000380932; ENSG00000214216. [Q1A5X6-2]
ENST00000451172; ENSP00000402153; ENSG00000214216. [Q1A5X6-1]
ENST00000482126; ENSP00000418141; ENSG00000214216. [Q1A5X6-3]
GeneIDi654502.
KEGGihsa:654502.
UCSCiuc003fco.4. human. [Q1A5X6-1]

Organism-specific databases

CTDi654502.
GeneCardsiIQCJ.
H-InvDBHIX0003811.
HGNCiHGNC:32406. IQCJ.
HPAiHPA052835.
MIMi611622. gene.
neXtProtiNX_Q1A5X6.
PharmGKBiPA143485504.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0SC. Eukaryota.
ENOG410YSGH. LUCA.
GeneTreeiENSGT00390000000847.
HOGENOMiHOG000082511.
HOVERGENiHBG106631.
InParanoidiQ1A5X6.
OMAiLIIQRAW.
OrthoDBiEOG7DNNXW.
PhylomeDBiQ1A5X6.
TreeFamiTF336256.

Miscellaneous databases

ChiTaRSiIQCJ. human.
GenomeRNAii654502.
PROiQ1A5X6.
SOURCEiSearch...

Gene expression databases

BgeeiQ1A5X6.
CleanExiHS_IQCJ.

Family and domain databases

InterProiIPR029362. IQCJ-SCHIP1.
[Graphical view]
PfamiPF15157. IQCJ-SCHIP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein."
    Kwasnicka-Crawford D.A., Carson A.R., Scherer S.W.
    Biochem. Biophys. Res. Commun. 350:890-899(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5 AND 6).
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).

Entry informationi

Entry nameiIQCJ_HUMAN
AccessioniPrimary (citable) accession number: Q1A5X6
Secondary accession number(s): B7ZMM2, B9EH97, Q1A5X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.