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Protein

Cytochrome b-245 light chain

Gene

p22phox

Organism
Siniperca chuatsi (Mandarin fish)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport
LigandHemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-245 light chainUniRule annotation
Alternative name(s):
Cytochrome b(558) alpha chainUniRule annotation
Cytochrome b558 subunit alphaUniRule annotation
Neutrophil cytochrome b 22 kDa polypeptideUniRule annotation
Superoxide-generating NADPH oxidase light chain subunitUniRule annotation
p22 phagocyte B-cytochromeUniRule annotation
p22-phoxUniRule annotation
Gene namesi
Name:p22phoxImported
OrganismiSiniperca chuatsi (Mandarin fish)Imported
Taxonomic identifieri119488 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaCentrarchiformesCentrarchoideiSinipercidaeSiniperca

Subcellular locationi

  • Cell membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalSequence analysisAdd BLAST19
Transmembranei36 – 54HelicalSequence analysisAdd BLAST19
Transmembranei103 – 126HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the p22phox family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG051278.

Family and domain databases

InterProiView protein in InterPro
IPR007732. Cyt_b558_asu.
PANTHERiPTHR15168. PTHR15168. 1 hit.
PfamiView protein in Pfam
PF05038. Cytochrom_B558a. 1 hit.
PIRSFiPIRSF019635. Cytochr_b558a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1A3R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIEWAMWA NEQALASGFI LLTGGIVGVA GQFRGWQFAA YAVAAGVFVC
60 70 80 90 100
LLEYPRSKRS KGTSVERTGQ YCFTVCVKGF GPLTRNYYVR AFLHAAISVP
110 120 130 140 150
GGFMLATVLG CVCLGIASLI YLVAAIRGEH WEPILPTKEI RKPVGESIKN
160 170 180
PPQNPPPRPP PEMRRKRVDD LEGAAYDNPI SVTANE
Length:186
Mass (Da):20,271
Last modified:July 11, 2006 - v1
Checksum:iEC76E47AC349CE3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ341376 mRNA. Translation: ABC72123.1.

Similar proteinsi

Entry informationi

Entry nameiQ1A3R9_SINCH
AccessioniPrimary (citable) accession number: Q1A3R9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 10, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)