Unreviewed, UniProtKB/TrEMBL Q19R07 (Q19R07_HUMAN)

Names and origin

Protein names

Submitted name:
    T calcium channel alpha 1G subunit variant 157 EMBL ABF69911.1

Gene names

Name:

CACNA1G EMBL ABF69911.1

Organism

Homo sapiens (Human) EMBL ABF69911.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q19R07-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 8C9D69B5A3C86C21	FASTA	2,314	256,024
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRKA QCKPYYSDYS RFRLLVHHLC TSHYLDLFIT GVIGLNVVTM AMEHYQQPQI 1630 1640 1650 1660 1670 1680 LDEALKICNY IFTVIFVLES VFKLVAFGFR RFFQDRWNQL DLAIVLLSIM GITLEEIEVN 1690 1700 1710 1720 1730 1740 ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ ALPQVGNLGL LFMLLFFIFA 1750 1760 1770 1780 1790 1800 ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV STGDNWNGIM KDTLRDCDQE 1810 1820 1830 1840 1850 1860 STCYNTVISP IYFVSFVLTA QFVLVNVVIA VLMKHLEESN KEAKEEAELE AELELEMKTL 1870 1880 1890 1900 1910 1920 SPQPHSPLGS PFLWPGVEGP DSPDSPKPGA LHPAAHARSA SHFSLEHPTD RQLFDTISLL 1930 1940 1950 1960 1970 1980 IQGSLEWELK LMDELAGPGG QPSAFPSAPS LGGSDPQMQP HPTELPGPDL LTVRKSGVSR 1990 2000 2010 2020 2030 2040 THSLPNDSYM CRHGSTAEGP LGHRGWGLPK AQSGSVLSVH SQPADTSYIL QLPKDAPHLL 2050 2060 2070 2080 2090 2100 QPHSAPTWGT IPKLPPPGRS PLAQRPLRRQ AAIRTDSLDV QGLGSREDLL AEVSGPSPPL 2110 2120 2130 2140 2150 2160 ARAYSFWGQS STQAQQHSRS HSKISKHMTP PAPCPGPEPN WGKGPPETRS SLELDTELSW 2170 2180 2190 2200 2210 2220 ISGDLLPPGG QEEPPSPRDL KKCYSVEAQS CQRRPTSWLD EQRRHSIAVS CLDSGSQPHL 2230 2240 2250 2260 2270 2280 GTDPSNLGGQ PLGGPGSRPK KKLSPPSITI DPPESQGPRT PPSPGICLRR RAPSSDSKDP 2290 2300 2310 LASGPPDSMA ASPSPKKDVL SLSGLSSDPA DLDP

References

[1]	"Profiling the Array of Cav3.1 Variants from the Human T-type Calcium Channel Gene CACNA1G: Alternative Structures, Developmental Expression, and Biophysical Variations." Emerick M.C., Stein R., Kunze R., McNulty M.M., Regan M.R., Hanck D.A., Agnew W.S. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ494460 mRNA. Translation: ABF69911.1.
IPI	IPI00219396.
UniGene	Hs.591169
3D structure databases
SMR	Q19R07. Positions 737-969, 1271-1543.
ModBase	Search...
Protein-protein interaction databases
STRING	Q19R07.
Genome annotation databases
Ensembl	ENST00000354424; ENSP00000346406; ENSG00000006283; Homo sapiens. [Genome view]
UCSC	uc002isf.1. human.
Organism-specific databases
HGNC	HGNC:1394. CACNA1G.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q19R07.
Gene expression databases
ArrayExpress	Q19R07.
Bgee	Q19R07.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR005445. VDCC_T_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF44. TVDCCAlpha1. 1 hit.
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01629. TVDCCALPHA1.
ProtoNet	Search...

Entry information

Entry name

Q19R07_HUMAN

Accession

Primary (citable) accession number: Q19R07

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	January 19, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.