Unreviewed, UniProtKB/TrEMBL Q19R02 (Q19R02_HUMAN)

Names and origin

Protein names

Submitted name:
    T calcium channel alpha 1G subunit variant 189 EMBL ABF69916.1

Gene names

Name:

CACNA1G EMBL ABF69916.1

Organism

Homo sapiens (Human) EMBL ABF69916.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q19R02-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 74F41CEA601E8CBC	FASTA	2,332	257,716
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV 1630 1640 1650 1660 1670 1680 IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL 1690 1700 1710 1720 1730 1740 AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL 1750 1760 1770 1780 1790 1800 PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 1810 1820 1830 1840 1850 1860 GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE 1870 1880 1890 1900 1910 1920 AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH 1930 1940 1950 1960 1970 1980 FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQMQPHP 1990 2000 2010 2020 2030 2040 TELPGPDLLT VRKSGVSRTH SLPNDSYMCR HGSTAEGPLG HRGWGLPKAQ SGSVLSVHSQ 2050 2060 2070 2080 2090 2100 PADTSYILQL PKDAPHLLQP HSAPTWGTIP KLPPPGRSPL AQRPLRRQAA IRTDSLDVQG 2110 2120 2130 2140 2150 2160 LGSREDLLAE VSGPSPPLAR AYSFWGQSST QAQQHSRSHS KISKHMTPPA PCPGPEPNWG 2170 2180 2190 2200 2210 2220 KGPPETRSSL ELDTELSWIS GDLLPPGGQE EPPSPRDLKK CYSVEAQSCQ RRPTSWLDEQ 2230 2240 2250 2260 2270 2280 RRHSIAVSCL DSGSQPHLGT DPSNLGGQPL GGPGSRPKKK LSPPSITIDP PESQGPRTPP 2290 2300 2310 2320 2330 SPGICLRRRA PSSDSKDPLA SGPPDSMAAS PSPKKDVLSL SGLSSDPADL DP

References

[1]	"Profiling the Array of Cav3.1 Variants from the Human T-type Calcium Channel Gene CACNA1G: Alternative Structures, Developmental Expression, and Biophysical Variations." Emerick M.C., Stein R., Kunze R., McNulty M.M., Regan M.R., Hanck D.A., Agnew W.S. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ494465 mRNA. Translation: ABF69916.1.
IPI	IPI00218689.
RefSeq	NP_938199.1.
UniGene	Hs.591169
3D structure databases
SMR	Q19R02. Positions 737-969, 1271-1543.
ModBase	Search...
Protein-protein interaction databases
STRING	Q19R02.
Proteomic databases
PRIDE	Q19R02.
Genome annotation databases
Ensembl	ENST00000354424; ENSP00000346406; ENSG00000006283; Homo sapiens. [Genome view]
GeneID	8913.
UCSC	uc002irp.1. human.
Organism-specific databases
CTD	8913.
HGNC	HGNC:1394. CACNA1G.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q19R02.
Gene expression databases
ArrayExpress	Q19R02.
Bgee	Q19R02.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR005445. VDCC_T_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF44. TVDCCAlpha1. 1 hit.
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01629. TVDCCALPHA1.
ProtoNet	Search...
Other Resources
NextBio	33500.

Entry information

Entry name

Q19R02_HUMAN

Accession

Primary (citable) accession number: Q19R02

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.