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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

Cyp11a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00229.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
Gene namesi
Name:Cyp11a1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi69325. Cyp11a1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ19P45.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG102141.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR033283. CYP11A1.
IPR001128. Cyt_P450.
IPR002399. Cyt_P450_mitochondrial.
IPR036396. Cyt_P450_sf.
PANTHERiPTHR24279:SF3. PTHR24279:SF3. 1 hit.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00408. MITP450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q19P45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LCLRSVLVKS CQPFLSPVWQ GPGLATGNGA GISSTNSPRS FNEIPSPGDN
60 70 80 90 100
GWINLYHFLR ENGTHRIHYH HMQNFQKYGP IYREKLGNME SVYILDPKDA
110 120 130 140 150
ATLFSCEGPN PERYLVPPWV AYHQYYQRPI GVLFKSSDAW RKDRIVLNQE
160 170 180
VMAPDSIKNF VPLLEGVAQD FIKVLHRRIK QQ
Length:182
Mass (Da):20,867
Last modified:July 11, 2006 - v1
Checksum:i830425ADBEFCF915
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei182Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ515795 mRNA. Translation: ABF70958.1.
UniGeneiRn.1401.

Similar proteinsi

Entry informationi

Entry nameiQ19P45_RAT
AccessioniPrimary (citable) accession number: Q19P45
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)