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Protein

Alpha-1B-glycoprotein

Gene

A1bg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Protein family/group databases

MEROPSiI43.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
Gene namesi
Name:A1bg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2152878. A1bg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 512494Alpha-1B-glycoproteinPRO_0000355542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
Glycosylationi89 – 891N-linked (GlcNAc...)1 Publication
Disulfide bondi153 ↔ 195PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 292PROSITE-ProRule annotation
Disulfide bondi343 ↔ 392PROSITE-ProRule annotation
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 488PROSITE-ProRule annotation
Glycosylationi485 – 4851N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ19LI2.
PaxDbiQ19LI2.
PRIDEiQ19LI2.

PTM databases

iPTMnetiQ19LI2.
PhosphoSiteiQ19LI2.
SwissPalmiQ19LI2.

Expressioni

Tissue specificityi

Expressed in the liver hepatocytes of male and female GH transgenic mice and in the liver of female, but not of male, non-transgenic mice.1 Publication

Developmental stagei

Expressed at 3-days but not at 11-days of age in both female and male GH transgenic mice. Expression in the normal female mice begins as early as 2 months and is detected at much higher levels at 5, 12 and 24 months while at 30 months, expression is lower.1 Publication

Inductioni

Induced in hepatocytes during the proliferative phase of liver regeneration. Induction requires a continuous pattern of GH (growth hormaone) secretion and an intact GH-GH receptor-signaling complex.1 Publication

Gene expression databases

BgeeiQ19LI2.

Interactioni

Subunit structurei

Interacts with CRISP3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094151.

Structurei

3D structure databases

ProteinModelPortaliQ19LI2.
SMRiQ19LI2. Positions 288-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 126105Ig-like V-type 1Add
BLAST
Domaini127 – 21993Ig-like V-type 2Add
BLAST
Domaini220 – 31293Ig-like V-type 3Add
BLAST
Domaini313 – 415103Ig-like V-type 4Add
BLAST
Domaini416 – 51297Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiQ19LI2.
OMAiRCRYRSW.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ19LI2.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q19LI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLATVLLL WGFTLGPGNT LMLDSGSEPK LWAEPQSLLE PWANLTLVCA
60 70 80 90 100
VDLPTKVFEL IQNGWFLSQV RLETQVLSYR FSLGAITSNN SGIYRCRCGV
110 120 130 140 150
EPPVDIHLPA LNKWTMLSNA VEVTGKEPLP RPLAHADPVD WITPGGLPVY
160 170 180 190 200
VMCQVAMRGV TYLLRQEGVD GVQKPDVQHK GTAGFLIYKP GNYSCSYLTH
210 220 230 240 250
AAGEPSEPSD IVTIKMYASQ APPTLCLMGN YLMIYPQKTY ETLACKAPRN
260 270 280 290 300
AAEFQLRQGG KVLKIHGFSP TRDAILYYVN LKELDNPGPF TCRYRMHKYM
310 320 330 340 350
HVWSEDSKPV ELMWSDETLQ APVLTAEPSS RDLEPGSTVQ LRCTAPVSGL
360 370 380 390 400
RFGLQRQGKP ELVVVQMLNS SGTEAVFELH NISTIDSGNY SCIYMEQAPP
410 420 430 440 450
FSGSSSSEPV ELRVNGPPPK PRLEALWKST VHLGQEAIFR CHGHVPRVSM
460 470 480 490 500
ELVREGFKTP FAVASTRSTS AYLKLLFVGP QHAGNYSCRY TALPPFTFES
510
GISDPVEVIV EG
Length:512
Mass (Da):56,554
Last modified:July 11, 2006 - v1
Checksum:iB511CDCF0D26677A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ520794 mRNA. Translation: ABF68843.1.
CH466545 Genomic DNA. Translation: EDL29338.1.
CCDSiCCDS37085.1.
RefSeqiNP_001074536.1. NM_001081067.1.
UniGeneiMm.291499.

Genome annotation databases

EnsembliENSMUST00000096418; ENSMUSP00000094151; ENSMUSG00000022347.
GeneIDi117586.
KEGGimmu:117586.
UCSCiuc007vyd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ520794 mRNA. Translation: ABF68843.1.
CH466545 Genomic DNA. Translation: EDL29338.1.
CCDSiCCDS37085.1.
RefSeqiNP_001074536.1. NM_001081067.1.
UniGeneiMm.291499.

3D structure databases

ProteinModelPortaliQ19LI2.
SMRiQ19LI2. Positions 288-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094151.

Protein family/group databases

MEROPSiI43.950.

PTM databases

iPTMnetiQ19LI2.
PhosphoSiteiQ19LI2.
SwissPalmiQ19LI2.

Proteomic databases

MaxQBiQ19LI2.
PaxDbiQ19LI2.
PRIDEiQ19LI2.

Protocols and materials databases

DNASUi117586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096418; ENSMUSP00000094151; ENSMUSG00000022347.
GeneIDi117586.
KEGGimmu:117586.
UCSCiuc007vyd.1. mouse.

Organism-specific databases

CTDi1.
MGIiMGI:2152878. A1bg.

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiQ19LI2.
OMAiRCRYRSW.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ19LI2.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiQ19LI2.
SOURCEiSearch...

Gene expression databases

BgeeiQ19LI2.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A liver specific gene that is expressed in growth hormone transgenic mice and in normal female mice as a function of age."
    Tiong J.D.R., Gosney E., Ding J., Chin E., Kopchick J.J.
    Growth Horm. IGF Res. 16:145-156(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
    Tissue: Liver.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89 AND ASN-485.
    Strain: C57BL/6J.
    Tissue: Plasma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiA1BG_MOUSE
AccessioniPrimary (citable) accession number: Q19LI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 11, 2006
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.