ID   Q19KF7_NEIME            Unreviewed;       281 AA.
AC   Q19KF7;
DT   11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2006, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Lipoprotein GNA1870 {ECO:0000313|EMBL:ABF82029.1};
GN   Name=gna1870 {ECO:0000313|EMBL:ABF82029.1};
OS   Neisseria meningitidis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=487 {ECO:0000313|EMBL:ABF82029.1};
RN   [1] {ECO:0000313|EMBL:ABF82029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M1239 {ECO:0000313|EMBL:ABF82029.1};
RX   PubMed=16829612; DOI=10.1128/CVI.00097-06;
RA   Beernink P.T., Leipus A., Granoff D.M.;
RT   "Rapid genetic grouping of factor h-binding protein (genome-derived
RT   neisserial antigen 1870), a promising group B meningococcal vaccine
RT   candidate.";
RL   Clin. Vaccine Immunol. 13:758-763(2006).
RN   [2] {ECO:0007829|PDB:4AYI, ECO:0007829|PDB:4AYM}
RP   X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 32-281.
RX   PubMed=23133374; DOI=10.1371/journal.ppat.1002981;
RA   Johnson S., Tan L., van der Veen S., Caesar J., Goicoechea De Jorge E.,
RA   Harding R.J., Bai X., Exley R.M., Ward P.N., Ruivo N., Trivedi K.,
RA   Cumber E., Jones R., Newham L., Staunton D., Ufret-Vincenty R., Borrow R.,
RA   Pickering M.C., Lea S.M., Tang C.M.;
RT   "Design and evaluation of meningococcal vaccines through structure-based
RT   modification of host and pathogen molecules.";
RL   PLoS Pathog. 8:E1002981-E1002981(2012).
RN   [3] {ECO:0007829|PDB:6H2Y}
RP   X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 32-281.
RX   PubMed=31442074; DOI=10.1096/fj.201900374R;
RA   Bianchi F., Veggi D., Santini L., Buricchi F., Bartolini E., Lo Surdo P.,
RA   Martinelli M., Finco O., Masignani V., Bottomley M.J., Maione D., Cozzi R.;
RT   "Cocrystal structure of meningococcal factor H binding protein variant 3
RT   reveals a new crossprotective epitope recognized by human mAb 1E6.";
RL   FASEB J. 33:12099-12111(2019).
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DR   EMBL; DQ523569; ABF82029.1; -; Genomic_DNA.
DR   PDB; 4AYI; X-ray; 2.31 A; D=32-281.
DR   PDB; 4AYM; X-ray; 3.00 A; C/D=32-281.
DR   PDB; 6H2Y; X-ray; 2.65 A; D=32-281.
DR   PDBsum; 4AYI; -.
DR   PDBsum; 4AYM; -.
DR   PDBsum; 6H2Y; -.
DR   AlphaFoldDB; Q19KF7; -.
DR   SMR; Q19KF7; -.
DR   ABCD; Q19KF7; 1 sequenced antibody.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.90; -; 1.
DR   Gene3D; 2.60.40.1980; -; 1.
DR   InterPro; IPR049378; FHBP.
DR   InterPro; IPR014902; FHBP-like_C.
DR   InterPro; IPR049377; FHBP_N.
DR   InterPro; IPR011250; OMP/PagP_b-brl.
DR   NCBIfam; NF041466; factorH_bind; 1.
DR   Pfam; PF08794; FHBP_C; 1.
DR   Pfam; PF20937; FHBP_N; 1.
DR   SUPFAM; SSF56925; OMPA-like; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4AYI, ECO:0007829|PDB:4AYM};
KW   Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW   Lipoprotein {ECO:0000313|EMBL:ABF82029.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023237}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..281
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004187217"
FT   DOMAIN          8..101
FT                   /note="Factor H binding protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20937"
FT   DOMAIN          170..264
FT                   /note="Factor H binding protein-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08794"
SQ   SEQUENCE   281 AA;  29806 MW;  C3A4870B601898C9 CRC64;
     MNRTAFCCLS LTTALILTAC SSGGGGSGGG GVAADIGTGL ADALTAPLDH KDKGLKSLTL
     EDSIPQNGTL TLSAQGAEKT FKAGDKDNSL NTGKLKNDKI SRFDFVQKIE VDGQTITLAS
     GEFQIYKQNH SAVVALQIEK INNPDKTDSL INQRSFLVSG LGGEHTAFNQ LPGGKAEYHG
     KAFSSDDPNG RLHYSIDFTK KQGYGRIEHL KTLEQNVELA AAELKADEKS HAVILGDTRY
     GSEEKGTYHL ALFGDRAQEI AGSATVKIGE KVHEIGIAGK Q
//