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Q19KA1

- G6PC_FELCA

UniProt

Q19KA1 - G6PC_FELCA

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Protein

Glucose-6-phosphatase

Gene
G6PC
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels By similarity.

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Substrate Reviewed prediction
Active sitei119 – 1191Proton donor Reviewed prediction
Binding sitei170 – 1701Substrate Reviewed prediction
Active sitei176 – 1761Nucleophile By similarity

GO - Molecular functioni

  1. glucose-6-phosphatase activity Source: UniProtKB-EC
  2. phosphate ion binding Source: Ensembl
  3. phosphotransferase activity, alcohol group as acceptor Source: Ensembl

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. gluconeogenesis Source: UniProtKB-UniPathway
  3. glucose 6-phosphate metabolic process Source: Ensembl
  4. glucose-6-phosphate transport Source: Ensembl
  5. glucose homeostasis Source: Ensembl
  6. glycogen catabolic process Source: Ensembl
  7. multicellular organism growth Source: Ensembl
  8. regulation of gene expression Source: Ensembl
  9. steroid metabolic process Source: Ensembl
  10. triglyceride metabolic process Source: Ensembl
  11. urate metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Gluconeogenesis

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase (EC:3.1.3.9)
Short name:
G-6-Pase
Short name:
G6Pase
Gene namesi
Name:G6PC
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome E1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Lumenal Reviewed predictionAdd
BLAST
Transmembranei29 – 4921Helical; Reviewed predictionAdd
BLAST
Topological domaini50 – 6011Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei61 – 8121Helical; Reviewed predictionAdd
BLAST
Topological domaini82 – 11736Lumenal Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Topological domaini139 – 1479Cytoplasmic Reviewed prediction
Transmembranei148 – 16821Helical; Reviewed predictionAdd
BLAST
Topological domaini169 – 1702Lumenal Reviewed prediction
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Topological domaini192 – 20918Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei210 – 23021Helical; Reviewed predictionAdd
BLAST
Topological domaini231 – 25424Lumenal Reviewed predictionAdd
BLAST
Transmembranei255 – 27521Helical; Reviewed predictionAdd
BLAST
Topological domaini276 – 29116Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Topological domaini313 – 3208Lumenal Reviewed prediction
Transmembranei321 – 34121Helical; Reviewed predictionAdd
BLAST
Topological domaini342 – 35716Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Glucose-6-phosphatasePRO_0000350563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000012186.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi354 – 3574Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82628.
GeneTreeiENSGT00510000046465.
HOGENOMiHOG000264239.
HOVERGENiHBG003560.
KOiK01084.
OMAiYLQVNYQ.
TreeFamiTF324388.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19KA1-1 [UniParc]FASTAAdd to Basket

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MEKGMNVLHD FGIQSTHYLQ VNYQDSQDWF ILVSVIADLR NAFYVLFPIW    50
FHLREAVGIK LLWVAVIGDW LNLVFKWILF GQRPYWWVMD TDYYSNASVP 100
LIKQFPVTCE TGPGSPSGHA MGTAGVYYVM VTSTLSMFRG KKKPTYRFRC 150
LNVILWLGFW AVQLNVCLSR IYLAAHFPHQ VVAGVLSGIA VAETFRHIQS 200
IYNASLKKYF FITFFLLSFA IGFYLLLKGL GVDLLWTLEK ARRWCERPEW 250
VHIDTTPFAS LLKNVGTLFG LGLALNSSMY RESCKGTLSK WFPFRLSCIV 300
VSLILLHLFD SLKPPSQIEL IFYVLSFCKS AAVPLASVSL IPYCLARVLG 350
QPDKKSL 357
Length:357
Mass (Da):40,761
Last modified:July 11, 2006 - v1
Checksum:iE821097701C7FF16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ525410 mRNA. Translation: ABF82030.1.
RefSeqiNP_001035837.1. NM_001042378.1.

Genome annotation databases

EnsembliENSFCAT00000013143; ENSFCAP00000012186; ENSFCAG00000013139.
GeneIDi723970.
KEGGifca:723970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ525410 mRNA. Translation: ABF82030.1 .
RefSeqi NP_001035837.1. NM_001042378.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000012186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000013143 ; ENSFCAP00000012186 ; ENSFCAG00000013139 .
GeneIDi 723970.
KEGGi fca:723970.

Organism-specific databases

CTDi 2538.

Phylogenomic databases

eggNOGi NOG82628.
GeneTreei ENSGT00510000046465.
HOGENOMi HOG000264239.
HOVERGENi HBG003560.
KOi K01084.
OMAi YLQVNYQ.
TreeFami TF324388.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR016275. Glucose-6-phosphatase.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and comparative bioinformatic analysis of feline glucose-6-phosphatase catalytic subunit cDNA."
    Lindbloom S., LeCluyse M., Schermerhorn T.
    DNA Seq. 19:256-263(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PC_FELCA
AccessioniPrimary (citable) accession number: Q19KA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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