Reviewed, UniProtKB/Swiss-Prot Q19KA1 (G6PC_FELCA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphatase
      Short name=G-6-Pase
      Short name=G6Pase
    EC=3.1.3.9

Gene names

Name:

G6PC

Organism

Felis silvestris catus (Cat)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels By similarity.
Catalytic activity	D-glucose 6-phosphate + H2O = D-glucose + phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glucose-6-phosphatase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucose-6-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Glucose-6-phosphatase		PRO_0000350563
Regions
	Topological domain	1 – 28	28	Lumenal Potential
	Transmembrane	29 – 49	21	Potential
	Topological domain	50 – 60	11	Cytoplasmic Potential
	Transmembrane	61 – 81	21	Potential
	Topological domain	82 – 117	36	Lumenal Potential
	Transmembrane	118 – 138	21	Potential
	Topological domain	139 – 147	9	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Potential
	Topological domain	169 – 170	2	Lumenal Potential
	Transmembrane	171 – 191	21	Potential
	Topological domain	192 – 209	18	Cytoplasmic Potential
	Transmembrane	210 – 230	21	Potential
	Topological domain	231 – 254	24	Lumenal Potential
	Transmembrane	255 – 275	21	Potential
	Topological domain	276 – 291	16	Cytoplasmic Potential
	Transmembrane	292 – 312	21	Potential
	Topological domain	313 – 320	8	Lumenal Potential
	Transmembrane	321 – 341	21	Potential
	Topological domain	342 – 357	16	Cytoplasmic Potential
	Motif	354 – 357	4	Prevents secretion from ER Potential
Sites
	Active site	119	1	Proton donor Potential
	Active site	176	1	Nucleophile By similarity
	Binding site	83	1	Substrate Potential
	Binding site	170	1	Substrate Potential
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q19KA1-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: E821097701C7FF16	FASTA	357	40,761
	10 20 30 40 50 60 MEKGMNVLHD FGIQSTHYLQ VNYQDSQDWF ILVSVIADLR NAFYVLFPIW FHLREAVGIK 70 80 90 100 110 120 LLWVAVIGDW LNLVFKWILF GQRPYWWVMD TDYYSNASVP LIKQFPVTCE TGPGSPSGHA 130 140 150 160 170 180 MGTAGVYYVM VTSTLSMFRG KKKPTYRFRC LNVILWLGFW AVQLNVCLSR IYLAAHFPHQ 190 200 210 220 230 240 VVAGVLSGIA VAETFRHIQS IYNASLKKYF FITFFLLSFA IGFYLLLKGL GVDLLWTLEK 250 260 270 280 290 300 ARRWCERPEW VHIDTTPFAS LLKNVGTLFG LGLALNSSMY RESCKGTLSK WFPFRLSCIV 310 320 330 340 350 VSLILLHLFD SLKPPSQIEL IFYVLSFCKS AAVPLASVSL IPYCLARVLG QPDKKSL

References

[1]	"Cloning and comparative bioinformatic analysis of feline glucose-6-phosphatase catalytic subunit cDNA." Lindbloom S., LeCluyse M., Schermerhorn T. DNA Seq. 19:256-263(2008) [PubMed: 17852328] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ525410 mRNA. Translation: ABF82030.1.
RefSeq	NP_001035837.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	723970.
Phylogenomic databases
HOVERGEN	Q19KA1.
OMA	Q19KA1. FYLLLKG.
Family and domain databases
InterPro	IPR016275. Glucose-6-phosphatase. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
PIRSF	PIRSF000905. Glucose-6-phosphatase. 1 hit.
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PC_FELCA

Accession

Primary (citable) accession number: Q19KA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	July 11, 2006
Last modified:	May 5, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)