Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q19KA1

- G6PC_FELCA

UniProt

Q19KA1 - G6PC_FELCA

Protein

Glucose-6-phosphatase

Gene

G6PC

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + H2O = D-glucose + phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei83 – 831SubstrateSequence Analysis
    Active sitei119 – 1191Proton donorSequence Analysis
    Binding sitei170 – 1701SubstrateSequence Analysis
    Active sitei176 – 1761NucleophileBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphatase activity Source: UniProtKB-EC
    2. phosphate ion binding Source: Ensembl
    3. phosphotransferase activity, alcohol group as acceptor Source: Ensembl

    GO - Biological processi

    1. cholesterol homeostasis Source: Ensembl
    2. gluconeogenesis Source: UniProtKB-UniPathway
    3. glucose 6-phosphate metabolic process Source: Ensembl
    4. glucose-6-phosphate transport Source: Ensembl
    5. glucose homeostasis Source: Ensembl
    6. glycogen catabolic process Source: Ensembl
    7. multicellular organism growth Source: Ensembl
    8. regulation of gene expression Source: Ensembl
    9. steroid metabolic process Source: Ensembl
    10. triglyceride metabolic process Source: Ensembl
    11. urate metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Gluconeogenesis

    Enzyme and pathway databases

    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphatase (EC:3.1.3.9)
    Short name:
    G-6-Pase
    Short name:
    G6Pase
    Gene namesi
    Name:G6PC
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome E1

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Glucose-6-phosphatasePRO_0000350563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000012186.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828LumenalSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 11736LumenalSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1479CytoplasmicSequence Analysis
    Topological domaini169 – 1702LumenalSequence Analysis
    Topological domaini192 – 20918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 25424LumenalSequence AnalysisAdd
    BLAST
    Topological domaini276 – 29116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini313 – 3208LumenalSequence Analysis
    Topological domaini342 – 35716CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi354 – 3574Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the glucose-6-phosphatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82628.
    GeneTreeiENSGT00510000046465.
    HOGENOMiHOG000264239.
    HOVERGENiHBG003560.
    KOiK01084.
    OMAiYLQVNYQ.
    TreeFamiTF324388.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q19KA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKGMNVLHD FGIQSTHYLQ VNYQDSQDWF ILVSVIADLR NAFYVLFPIW    50
    FHLREAVGIK LLWVAVIGDW LNLVFKWILF GQRPYWWVMD TDYYSNASVP 100
    LIKQFPVTCE TGPGSPSGHA MGTAGVYYVM VTSTLSMFRG KKKPTYRFRC 150
    LNVILWLGFW AVQLNVCLSR IYLAAHFPHQ VVAGVLSGIA VAETFRHIQS 200
    IYNASLKKYF FITFFLLSFA IGFYLLLKGL GVDLLWTLEK ARRWCERPEW 250
    VHIDTTPFAS LLKNVGTLFG LGLALNSSMY RESCKGTLSK WFPFRLSCIV 300
    VSLILLHLFD SLKPPSQIEL IFYVLSFCKS AAVPLASVSL IPYCLARVLG 350
    QPDKKSL 357
    Length:357
    Mass (Da):40,761
    Last modified:July 11, 2006 - v1
    Checksum:iE821097701C7FF16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ525410 mRNA. Translation: ABF82030.1.
    RefSeqiNP_001035837.1. NM_001042378.1.

    Genome annotation databases

    EnsembliENSFCAT00000013143; ENSFCAP00000012186; ENSFCAG00000013139.
    GeneIDi723970.
    KEGGifca:723970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ525410 mRNA. Translation: ABF82030.1 .
    RefSeqi NP_001035837.1. NM_001042378.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000012186.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000013143 ; ENSFCAP00000012186 ; ENSFCAG00000013139 .
    GeneIDi 723970.
    KEGGi fca:723970.

    Organism-specific databases

    CTDi 2538.

    Phylogenomic databases

    eggNOGi NOG82628.
    GeneTreei ENSGT00510000046465.
    HOGENOMi HOG000264239.
    HOVERGENi HBG003560.
    KOi K01084.
    OMAi YLQVNYQ.
    TreeFami TF324388.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR016275. Glucose-6-phosphatase.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000905. Glucose-6-phosphatase. 1 hit.
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and comparative bioinformatic analysis of feline glucose-6-phosphatase catalytic subunit cDNA."
      Lindbloom S., LeCluyse M., Schermerhorn T.
      DNA Seq. 19:256-263(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiG6PC_FELCA
    AccessioniPrimary (citable) accession number: Q19KA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3