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Protein

Zinc finger SWIM domain-containing protein 7

Gene

ZSWIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 7
Alternative name(s):
SWIM domain-containing and Srs2-interacting protein 1 homolog
SWIM-type zinc finger domain-containing protein 7
Gene namesi
Name:ZSWIM7
Synonyms:SWS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000214941.7.
HGNCiHGNC:26993. ZSWIM7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214941.
PharmGKBiPA162411055.

Polymorphism and mutation databases

BioMutaiZSWIM7.
DMDMi121940600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003074031 – 140Zinc finger SWIM domain-containing protein 7Add BLAST140

Proteomic databases

EPDiQ19AV6.
MaxQBiQ19AV6.
PaxDbiQ19AV6.
PeptideAtlasiQ19AV6.
PRIDEiQ19AV6.

PTM databases

iPTMnetiQ19AV6.
PhosphoSitePlusiQ19AV6.

Expressioni

Gene expression databases

BgeeiENSG00000214941.
CleanExiHS_ZSWIM7.
ExpressionAtlasiQ19AV6. baseline and differential.
GenevisibleiQ19AV6. HS.

Organism-specific databases

HPAiHPA054681.

Interactioni

Subunit structurei

Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWSAP1Q6NVH77EBI-5281647,EBI-5281637

Protein-protein interaction databases

BioGridi125919. 8 interactors.
IntActiQ19AV6. 3 interactors.
STRINGi9606.ENSP00000382218.

Structurei

3D structure databases

ProteinModelPortaliQ19AV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SWS1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 114SWIM-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWUY. Eukaryota.
ENOG4112D11. LUCA.
GeneTreeiENSGT00390000017523.
HOGENOMiHOG000006441.
HOVERGENiHBG105170.
InParanoidiQ19AV6.
OMAiLKFVFGS.
OrthoDBiEOG091G0SHF.
PhylomeDBiQ19AV6.
TreeFamiTF339438.

Family and domain databases

InterProiView protein in InterPro
IPR007527. Znf_SWIM.
PfamiView protein in Pfam
PF04434. SWIM. 1 hit.
PROSITEiView protein in PROSITE
PS50966. ZF_SWIM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVLPAVVE ELLSEMAAAV QESARIPDEY LLSLKFLFGS SATQALDLVD
60 70 80 90 100
RQSITLISSP SGRRVYQVLG SSSKTYTCLA SCHYCSCPAF AFSVLRKSDS
110 120 130 140
ILCKHLLAVY LSQVMRTCQQ LSVSDKQLTD ILLMEKKQEA
Length:140
Mass (Da):15,386
Last modified:July 11, 2006 - v1
Checksum:i4DECCC679C537F18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ530600 mRNA. Translation: ABF72190.1.
CCDSiCCDS42266.1.
RefSeqiNP_001036162.1. NM_001042697.1.
NP_001036163.1. NM_001042698.1.
UniGeneiHs.593985.

Genome annotation databases

EnsembliENST00000399277; ENSP00000382218; ENSG00000214941.
ENST00000472495; ENSP00000419138; ENSG00000214941.
GeneIDi125150.
KEGGihsa:125150.
UCSCiuc002gpe.4. human.

Similar proteinsi

Entry informationi

Entry nameiZSWM7_HUMAN
AccessioniPrimary (citable) accession number: Q19AV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 11, 2006
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families