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Protein

Zinc finger SWIM domain-containing protein 7

Gene

ZSWIM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri66 – 11449SWIM-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • protein stabilization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 7
Alternative name(s):
SWIM domain-containing and Srs2-interacting protein 1 homolog
SWIM-type zinc finger domain-containing protein 7
Gene namesi
Name:ZSWIM7
Synonyms:SWS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26993. ZSWIM7.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • Shu complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411055.

Polymorphism and mutation databases

BioMutaiZSWIM7.
DMDMi121940600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Zinc finger SWIM domain-containing protein 7PRO_0000307403Add
BLAST

Proteomic databases

MaxQBiQ19AV6.
PaxDbiQ19AV6.
PRIDEiQ19AV6.

PTM databases

iPTMnetiQ19AV6.
PhosphoSiteiQ19AV6.

Expressioni

Gene expression databases

BgeeiQ19AV6.
CleanExiHS_ZSWIM7.
ExpressionAtlasiQ19AV6. baseline and differential.
GenevisibleiQ19AV6. HS.

Organism-specific databases

HPAiHPA054681.

Interactioni

Subunit structurei

Interacts with RAD51D and XRCC3; involved in homologous recombination repair. Interacts with SWSAP1; they form a functional complex involved in homologous recombination repair and stabilize each other.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWSAP1Q6NVH77EBI-5281647,EBI-5281637

Protein-protein interaction databases

BioGridi125919. 8 interactions.
IntActiQ19AV6. 3 interactions.
STRINGi9606.ENSP00000382218.

Structurei

3D structure databases

ProteinModelPortaliQ19AV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SWS1 family.Curated
Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri66 – 11449SWIM-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IWUY. Eukaryota.
ENOG4112D11. LUCA.
GeneTreeiENSGT00390000017523.
HOGENOMiHOG000006441.
HOVERGENiHBG105170.
InParanoidiQ19AV6.
OMAiKHILAVY.
PhylomeDBiQ19AV6.
TreeFamiTF339438.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVLPAVVE ELLSEMAAAV QESARIPDEY LLSLKFLFGS SATQALDLVD
60 70 80 90 100
RQSITLISSP SGRRVYQVLG SSSKTYTCLA SCHYCSCPAF AFSVLRKSDS
110 120 130 140
ILCKHLLAVY LSQVMRTCQQ LSVSDKQLTD ILLMEKKQEA
Length:140
Mass (Da):15,386
Last modified:July 11, 2006 - v1
Checksum:i4DECCC679C537F18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ530600 mRNA. Translation: ABF72190.1.
CCDSiCCDS42266.1.
RefSeqiNP_001036162.1. NM_001042697.1.
NP_001036163.1. NM_001042698.1.
UniGeneiHs.593985.

Genome annotation databases

EnsembliENST00000399277; ENSP00000382218; ENSG00000214941.
ENST00000472495; ENSP00000419138; ENSG00000214941.
GeneIDi125150.
KEGGihsa:125150.
UCSCiuc002gpe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ530600 mRNA. Translation: ABF72190.1.
CCDSiCCDS42266.1.
RefSeqiNP_001036162.1. NM_001042697.1.
NP_001036163.1. NM_001042698.1.
UniGeneiHs.593985.

3D structure databases

ProteinModelPortaliQ19AV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125919. 8 interactions.
IntActiQ19AV6. 3 interactions.
STRINGi9606.ENSP00000382218.

PTM databases

iPTMnetiQ19AV6.
PhosphoSiteiQ19AV6.

Polymorphism and mutation databases

BioMutaiZSWIM7.
DMDMi121940600.

Proteomic databases

MaxQBiQ19AV6.
PaxDbiQ19AV6.
PRIDEiQ19AV6.

Protocols and materials databases

DNASUi125150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399277; ENSP00000382218; ENSG00000214941.
ENST00000472495; ENSP00000419138; ENSG00000214941.
GeneIDi125150.
KEGGihsa:125150.
UCSCiuc002gpe.4. human.

Organism-specific databases

CTDi125150.
GeneCardsiZSWIM7.
H-InvDBHIX0022477.
HGNCiHGNC:26993. ZSWIM7.
HPAiHPA054681.
MIMi614535. gene.
neXtProtiNX_Q19AV6.
PharmGKBiPA162411055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUY. Eukaryota.
ENOG4112D11. LUCA.
GeneTreeiENSGT00390000017523.
HOGENOMiHOG000006441.
HOVERGENiHBG105170.
InParanoidiQ19AV6.
OMAiKHILAVY.
PhylomeDBiQ19AV6.
TreeFamiTF339438.

Miscellaneous databases

ChiTaRSiZSWIM7. human.
GenomeRNAii125150.
NextBioi81499.
PROiQ19AV6.
SOURCEiSearch...

Gene expression databases

BgeeiQ19AV6.
CleanExiHS_ZSWIM7.
ExpressionAtlasiQ19AV6. baseline and differential.
GenevisibleiQ19AV6. HS.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sws1 is a conserved regulator of homologous recombination in eukaryotic cells."
    Martin V., Chahwan C., Gao H., Blais V., Wohlschlegel J., Yates J.R. III, McGowan C.H., Russell P.
    EMBO J. 25:2564-2574(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAD51D.
  2. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."
    Liu T., Wan L., Wu Y., Chen J., Huang J.
    J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HOMOLOGOUS RECOMBINATION REPAIR, INTERACTION WITH RAD51D; SWSAP1 AND XRCC3.

Entry informationi

Entry nameiZSWM7_HUMAN
AccessioniPrimary (citable) accession number: Q19AV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 11, 2006
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.