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Protein

Krueppel-like factor 14

Gene

Klf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: MGI

GO - Biological processi

  • positive regulation of sphingolipid mediated signaling pathway Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 14
Gene namesi
Name:Klf14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3577024. Klf14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Krueppel-like factor 14PRO_0000294169Add
BLAST

Proteomic databases

PRIDEiQ19A41.

Expressioni

Gene expression databases

BgeeiQ19A41.
CleanExiMM_KLF14.
GenevisibleiQ19A41. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099122.

Structurei

3D structure databases

ProteinModelPortaliQ19A41.
SMRiQ19A41. Positions 156-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22430C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 25430C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri255 – 28228C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ19A41.
KOiK09208.
OMAiEAPCAST.
OrthoDBiEOG7FJH0Q.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19A41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACLDY FAAECLVSMS TRAVLHRRAT DPEGASAAAV SEVGAVSRES
60 70 80 90 100
AGKGTGSRGV LWIPPVLQVP TPSPGEGDGA PHLLAASALA DLSCGAREDF
110 120 130 140 150
REDSEEAPCA STSCFEPTWC SSPTGGSEPT QAFFEDELSD AESSCSDSAI
160 170 180 190 200
LDAPEASEEP DDSGEVPEGP PGARPAPSTG PTYRRRQITP ASKRHQCSFH
210 220 230 240 250
GCNKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRPEPPP
310 320
PAMVESSGSD SSSSSGQETS FTACL
Length:325
Mass (Da):35,091
Last modified:July 11, 2006 - v1
Checksum:i5459637FFC0061BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ534758 mRNA. Translation: ABF82394.1.
CCDSiCCDS51744.1.
RefSeqiNP_001128565.1. NM_001135093.1.
UniGeneiMm.204671.

Genome annotation databases

EnsembliENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209.
GeneIDi619665.
KEGGimmu:619665.
UCSCiuc012ejp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ534758 mRNA. Translation: ABF82394.1.
CCDSiCCDS51744.1.
RefSeqiNP_001128565.1. NM_001135093.1.
UniGeneiMm.204671.

3D structure databases

ProteinModelPortaliQ19A41.
SMRiQ19A41. Positions 156-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099122.

Proteomic databases

PRIDEiQ19A41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209.
GeneIDi619665.
KEGGimmu:619665.
UCSCiuc012ejp.1. mouse.

Organism-specific databases

CTDi136259.
MGIiMGI:3577024. Klf14.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ19A41.
KOiK09208.
OMAiEAPCAST.
OrthoDBiEOG7FJH0Q.
TreeFamiTF351003.

Miscellaneous databases

NextBioi414786.
PROiQ19A41.
SOURCEiSearch...

Gene expression databases

BgeeiQ19A41.
CleanExiMM_KLF14.
GenevisibleiQ19A41. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The centre for applied genomics genome annotation project."
    Parker-Katiraee L., Scherer S.W.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKLF14_MOUSE
AccessioniPrimary (citable) accession number: Q19A41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.