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Protein

Krueppel-like factor 14

Gene

Klf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II transcription factor binding Source: MGI

GO - Biological processi

  • positive regulation of sphingolipid mediated signaling pathway Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 14
Gene namesi
Name:Klf14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3577024 Klf14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002941691 – 325Krueppel-like factor 14Add BLAST325

Proteomic databases

PaxDbiQ19A41
PRIDEiQ19A41

PTM databases

PhosphoSitePlusiQ19A41

Expressioni

Gene expression databases

BgeeiENSMUSG00000073209
CleanExiMM_KLF14
GenevisibleiQ19A41 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099122

Structurei

3D structure databases

ProteinModelPortaliQ19A41
SMRiQ19A41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri225 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri255 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ19A41
KOiK09208
OMAiWENSGEA
OrthoDBiEOG091G1BN0
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q19A41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACLDY FAAECLVSMS TRAVLHRRAT DPEGASAAAV SEVGAVSRES
60 70 80 90 100
AGKGTGSRGV LWIPPVLQVP TPSPGEGDGA PHLLAASALA DLSCGAREDF
110 120 130 140 150
REDSEEAPCA STSCFEPTWC SSPTGGSEPT QAFFEDELSD AESSCSDSAI
160 170 180 190 200
LDAPEASEEP DDSGEVPEGP PGARPAPSTG PTYRRRQITP ASKRHQCSFH
210 220 230 240 250
GCNKAYYKSS HLKSHQRTHT GERPFSCDWL DCDKKFTRSD ELARHYRTHT
260 270 280 290 300
GEKRFSCPLC PKQFSRSDHL TKHARRHPTY HPDMIEYRGR RRTPRPEPPP
310 320
PAMVESSGSD SSSSSGQETS FTACL
Length:325
Mass (Da):35,091
Last modified:July 11, 2006 - v1
Checksum:i5459637FFC0061BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ534758 mRNA Translation: ABF82394.1
CCDSiCCDS51744.1
RefSeqiNP_001128565.1, NM_001135093.1
UniGeneiMm.204671

Genome annotation databases

EnsembliENSMUST00000101589; ENSMUSP00000099122; ENSMUSG00000073209
GeneIDi619665
KEGGimmu:619665
UCSCiuc012ejp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF14_MOUSE
AccessioniPrimary (citable) accession number: Q19A41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health