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Q19A30

- AL9A1_ORYLA

UniProt

Q19A30 - AL9A1_ORYLA

Protein

Aldehyde dehydrogenase family 9 member A1

Gene

aldh9A1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei265 – 2651Sequence Analysis
    Active sitei299 – 2991Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi243 – 2486NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
    Gene namesi
    Name:aldh9A1
    Synonyms:aldh9
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Aldehyde dehydrogenase family 9 member A1PRO_0000300626Add
    BLAST

    Expressioni

    Tissue specificityi

    Constitutively expressed in all organs tested: brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis and ovary.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi8090.ENSORLP00000017772.

    Structurei

    3D structure databases

    ProteinModelPortaliQ19A30.
    SMRiQ19A30. Positions 6-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ19A30.
    KOiK00149.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q19A30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV    50
    LCQMVPCGAE EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE 100
    KIAKLEVINN GKSITEALVD IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF 150
    AYTRREPLGV CVGIGAWNYP FQIAACKSAP ALACGNAMVF KPSPFTPVTA 200
    VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS FTGSVPTGKK 250
    VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC 300
    NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV 350
    LGFVRQAKKE GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK 400
    EEIFGPVMSV LPFDTEEEVI RRANNTTFGL ASGVFTRDIS RAHRVAASLE 450
    AGTCFINNYN ISPVEVPFGG YKMSGFGREN GQVTIEYYSQ LKTVVVETGD 500
    VENYF 505
    Length:505
    Mass (Da):54,482
    Last modified:July 11, 2006 - v1
    Checksum:i2558A9F02C570638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ535181 mRNA. Translation: ABF83193.1.
    RefSeqiNP_001098318.1. NM_001104848.1.
    UniGeneiOla.6101.

    Genome annotation databases

    GeneIDi100049493.
    KEGGiola:100049493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ535181 mRNA. Translation: ABF83193.1 .
    RefSeqi NP_001098318.1. NM_001104848.1.
    UniGenei Ola.6101.

    3D structure databases

    ProteinModelPortali Q19A30.
    SMRi Q19A30. Positions 6-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8090.ENSORLP00000017772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100049493.
    KEGGi ola:100049493.

    Organism-specific databases

    CTDi 223.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q19A30.
    KOi K00149.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias latipes) embryogenesis."
      Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.
      Comp. Biochem. Physiol. 146B:357-363(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAL9A1_ORYLA
    AccessioniPrimary (citable) accession number: Q19A30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3