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Reviewed, UniProtKB/Swiss-Prot Q19A30 (AL9A1_ORYLA)

Last modified October 13, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase family 9 member A1
    EC=1.2.1.3
Gene names
Name: aldh9A1
Synonyms: aldh9
OrganismOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifier8090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias

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Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Constitutively expressed in all organs tested: brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis and ovary. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Aldehyde dehydrogenase family 9 member A1
PRO_0000300626

Regions

Nucleotide binding243 – 2486NAD By similarity

Sites

Active site2651 Potential
Active site2991 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q19A30-1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 2558A9F02C570638

FASTA50554,482
        10         20         30         40         50         60 
MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV LCQMVPCGAE 

        70         80         90        100        110        120 
EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE KIAKLEVINN GKSITEALVD 

       130        140        150        160        170        180 
IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF AYTRREPLGV CVGIGAWNYP FQIAACKSAP 

       190        200        210        220        230        240 
ALACGNAMVF KPSPFTPVTA VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS 

       250        260        270        280        290        300 
FTGSVPTGKK VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC 

       310        320        330        340        350        360 
NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV LGFVRQAKKE 

       370        380        390        400        410        420 
GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK EEIFGPVMSV LPFDTEEEVI 

       430        440        450        460        470        480 
RRANNTTFGL ASGVFTRDIS RAHRVAASLE AGTCFINNYN ISPVEVPFGG YKMSGFGREN 

       490        500 
GQVTIEYYSQ LKTVVVETGD VENYF

« Hide

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References

[1]"Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias latipes) embryogenesis."
Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.
Comp. Biochem. Physiol. 146B:357-363(2007) [PubMed: 17236798] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

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Cross-references

Sequence databases

DQ535181 mRNA. Translation: ABF83193.1.
RefSeqNP_001098318.1.
UniGeneOla.6101

3D structure databases

SMRQ19A30. Positions 6-505.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ19A30.

Genome annotation databases

EnsemblENSORLT00000017773; ENSORLP00000017772; ENSORLG00000014167; Oryzias latipes. [Genome view]
GeneID100049493.

Organism-specific databases

CTD100049493.

Phylogenomic databases

HOVERGENQ19A30.

Enzyme and pathway databases

BRENDA1.2.1.3. 19130.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAL9A1_ORYLA
AccessionPrimary (citable) accession number: Q19A30
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: October 13, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents