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Q19A30

- AL9A1_ORYLA

UniProt

Q19A30 - AL9A1_ORYLA

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Protein

Aldehyde dehydrogenase family 9 member A1

Gene
aldh9A1, aldh9
Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651 Reviewed prediction
Active sitei299 – 2991 Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2486NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:aldh9A1
Synonyms:aldh9
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Aldehyde dehydrogenase family 9 member A1PRO_0000300626Add
BLAST

Expressioni

Tissue specificityi

Constitutively expressed in all organs tested: brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis and ovary.1 Publication

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017772.

Structurei

3D structure databases

ProteinModelPortaliQ19A30.
SMRiQ19A30. Positions 6-503.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ19A30.
KOiK00149.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19A30-1 [UniParc]FASTAAdd to Basket

« Hide

MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV    50
LCQMVPCGAE EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE 100
KIAKLEVINN GKSITEALVD IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF 150
AYTRREPLGV CVGIGAWNYP FQIAACKSAP ALACGNAMVF KPSPFTPVTA 200
VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS FTGSVPTGKK 250
VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC 300
NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV 350
LGFVRQAKKE GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK 400
EEIFGPVMSV LPFDTEEEVI RRANNTTFGL ASGVFTRDIS RAHRVAASLE 450
AGTCFINNYN ISPVEVPFGG YKMSGFGREN GQVTIEYYSQ LKTVVVETGD 500
VENYF 505
Length:505
Mass (Da):54,482
Last modified:July 11, 2006 - v1
Checksum:i2558A9F02C570638
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ535181 mRNA. Translation: ABF83193.1.
RefSeqiNP_001098318.1. NM_001104848.1.
UniGeneiOla.6101.

Genome annotation databases

GeneIDi100049493.
KEGGiola:100049493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ535181 mRNA. Translation: ABF83193.1 .
RefSeqi NP_001098318.1. NM_001104848.1.
UniGenei Ola.6101.

3D structure databases

ProteinModelPortali Q19A30.
SMRi Q19A30. Positions 6-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8090.ENSORLP00000017772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100049493.
KEGGi ola:100049493.

Organism-specific databases

CTDi 223.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q19A30.
KOi K00149.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias latipes) embryogenesis."
    Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.
    Comp. Biochem. Physiol. 146B:357-363(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiAL9A1_ORYLA
AccessioniPrimary (citable) accession number: Q19A30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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