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Protein

Aldehyde dehydrogenase family 9 member A1

Gene

aldh9A1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651Sequence Analysis
Active sitei299 – 2991Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2486NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 9 member A1 (EC:1.2.1.3)
Gene namesi
Name:aldh9A1
Synonyms:aldh9
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Aldehyde dehydrogenase family 9 member A1PRO_0000300626Add
BLAST

Expressioni

Tissue specificityi

Constitutively expressed in all organs tested: brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis and ovary.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017772.

Structurei

3D structure databases

ProteinModelPortaliQ19A30.
SMRiQ19A30. Positions 6-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ19A30.
KOiK00149.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19A30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV
60 70 80 90 100
LCQMVPCGAE EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE
110 120 130 140 150
KIAKLEVINN GKSITEALVD IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF
160 170 180 190 200
AYTRREPLGV CVGIGAWNYP FQIAACKSAP ALACGNAMVF KPSPFTPVTA
210 220 230 240 250
VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS FTGSVPTGKK
260 270 280 290 300
VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC
310 320 330 340 350
NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV
360 370 380 390 400
LGFVRQAKKE GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK
410 420 430 440 450
EEIFGPVMSV LPFDTEEEVI RRANNTTFGL ASGVFTRDIS RAHRVAASLE
460 470 480 490 500
AGTCFINNYN ISPVEVPFGG YKMSGFGREN GQVTIEYYSQ LKTVVVETGD

VENYF
Length:505
Mass (Da):54,482
Last modified:July 11, 2006 - v1
Checksum:i2558A9F02C570638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ535181 mRNA. Translation: ABF83193.1.
RefSeqiNP_001098318.1. NM_001104848.1.
UniGeneiOla.6101.

Genome annotation databases

GeneIDi100049493.
KEGGiola:100049493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ535181 mRNA. Translation: ABF83193.1.
RefSeqiNP_001098318.1. NM_001104848.1.
UniGeneiOla.6101.

3D structure databases

ProteinModelPortaliQ19A30.
SMRiQ19A30. Positions 6-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000017772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100049493.
KEGGiola:100049493.

Organism-specific databases

CTDi223.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ19A30.
KOiK00149.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias latipes) embryogenesis."
    Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.
    Comp. Biochem. Physiol. 146B:357-363(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiAL9A1_ORYLA
AccessioniPrimary (citable) accession number: Q19A30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: April 29, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.