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Q19A30 (AL9A1_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 9 member A1
EC=1.2.1.3
Gene names
Name:aldh9A1
Synonyms:aldh9
OrganismOryzias latipes (Medaka fish) (Japanese ricefish) [Reference proteome]
Taxonomic identifier8090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Constitutively expressed in all organs tested: brain, eye, gill, GI, heart, liver, kidney, muscle, skin, testis and ovary. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Aldehyde dehydrogenase family 9 member A1
PRO_0000300626

Regions

Nucleotide binding243 – 2486NAD By similarity

Sites

Active site2651 Potential
Active site2991 Potential

Sequences

Sequence LengthMass (Da)Tools
Q19A30 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 2558A9F02C570638

FASTA50554,482
        10         20         30         40         50         60 
MSLATLDSMG GASTGSVTVT EQLNFWAGRR VGGRNSEHAE PVFEPATGRV LCQMVPCGAE 

        70         80         90        100        110        120 
EVDEAIMSAH AAYVQWSKKS GTERARVMLE AARIIRERRE KIAKLEVINN GKSITEALVD 

       130        140        150        160        170        180 
IDVAWQCIEY YAGVAGTLAG QHFQLPGGAF AYTRREPLGV CVGIGAWNYP FQIAACKSAP 

       190        200        210        220        230        240 
ALACGNAMVF KPSPFTPVTA VILAEIYKEA GVPDGLFCVV QGGAETGSLL CNHPKVAKVS 

       250        260        270        280        290        300 
FTGSVPTGKK VMEMSAKGVK QVTLELGGKS PLIIFKDCDL ENAVKGALMA NFLTQGQVCC 

       310        320        330        340        350        360 
NGTRVFVHKD ILPQFLEEVV KRTKAIAVGD PLLDSTRMGA LITKPHLEKV LGFVRQAKKE 

       370        380        390        400        410        420 
GGRVLCGGEP FVPSDPKLKG GYFMSPCILD NCRDDMTCVK EEIFGPVMSV LPFDTEEEVI 

       430        440        450        460        470        480 
RRANNTTFGL ASGVFTRDIS RAHRVAASLE AGTCFINNYN ISPVEVPFGG YKMSGFGREN 

       490        500 
GQVTIEYYSQ LKTVVVETGD VENYF

« Hide

References

[1]"Ethanol attenuates Aldh9 mRNA expression in Japanese medaka (Oryzias latipes) embryogenesis."
Wang X., Zhu S., Khan I.A., Dasmahapatra A.K.
Comp. Biochem. Physiol. 146B:357-363(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ535181 mRNA. Translation: ABF83193.1.
RefSeqNP_001098318.1. NM_001104848.1.
UniGeneOla.6101.

3D structure databases

ProteinModelPortalQ19A30.
SMRQ19A30. Positions 6-503.
ModBaseSearch...

Protein-protein interaction databases

STRING8090.ENSORLP00000017772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100049493.
KEGGola:100049493.

Organism-specific databases

CTD223.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
HOVERGENHBG000097.
InParanoidQ19A30.
KOK00149.
OrthoDBEOG4THVSW.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL9A1_ORYLA
AccessionPrimary (citable) accession number: Q19A30
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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