Q19980 (GCH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	cat-4
ORF Names:	F32G8.6

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Allosteric enzyme Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dopamine biosynthetic process Inferred from mutant phenotype PubMed 14739932. Source: WormBase melanin biosynthetic process Inferred from mutant phenotype PubMed 18460651. Source: WormBase tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
F45E4.3	H2KYL0	2	EBI-311852,EBI-2916517
T07D4.2	Q22306	2	EBI-311852,EBI-311847

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	GTP cyclohydrolase 1		PRO_0000119480
Sites
	Metal binding	113	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity
	Metal binding	184	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q19980 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B6584D6CBA6FA003	FASTA	223	25,132
	10 20 30 40 50 60 MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI IQHVGEDINR 70 80 90 100 110 120 QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE MVIVKDIEMF SLCEHHLVPF 130 140 150 160 170 180 MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA 190 200 210 220 SHMCMVMRGV QKINASTTTS CMLGVFRDDP KTREEFLNLI NKR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72509 Genomic DNA. Translation: CAA96650.1.
PIR	T21669.
RefSeq	NP_505710.1. NM_073309.5.
3D structure databases
ProteinModelPortal	Q19980.
SMR	Q19980. Positions 37-220.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-24416N.
IntAct	Q19980. 6 interactions.
MINT	MINT-1077330.
STRING	6239.F32G8.6.
Proteomic databases
PaxDb	Q19980.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F32G8.6; F32G8.6; F32G8.6.
GeneID	179472.
KEGG	cel:CELE_F32G8.6.
UCSC	F32G8.6. c. elegans.
Organism-specific databases
CTD	179472.
WormBase	F32G8.6; CE05795; WBGene00000298; cat-4.
Phylogenomic databases
eggNOG	COG0302.
GeneTree	ENSGT00390000013481.
HOGENOM	HOG000221222.
InParanoid	Q19980.
KO	K01495.
OMA	LYSVCEH.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	905542.

Entry information

Entry name

GCH1_CAEEL

Accession

Primary (citable) accession number: Q19980

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project