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Protein

GTP cyclohydrolase 1

Gene

cat-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131ZincBy similarity
Metal bindingi116 – 1161ZincBy similarity
Metal bindingi184 – 1841ZincBy similarity

GO - Molecular functioni

  1. GTP binding Source: GO_Central
  2. GTP cyclohydrolase I activity Source: GO_Central
  3. zinc ion binding Source: GO_Central

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. dopamine biosynthetic process Source: WormBase
  3. melanin biosynthetic process Source: WormBase
  4. tetrahydrobiopterin biosynthetic process Source: GO_Central
  5. tetrahydrofolate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:cat-4
ORF Names:F32G8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF32G8.6; CE05795; WBGene00000298; cat-4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223GTP cyclohydrolase 1PRO_0000119480Add
BLAST

Proteomic databases

PaxDbiQ19980.
PRIDEiQ19980.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
T07D4.2Q223062EBI-311852,EBI-311847
tag-80H2KYL02EBI-311852,EBI-2916517

Protein-protein interaction databases

BioGridi44501. 3 interactions.
DIPiDIP-24416N.
IntActiQ19980. 10 interactions.
MINTiMINT-1077330.
STRINGi6239.F32G8.6.

Structurei

3D structure databases

ProteinModelPortaliQ19980.
SMRiQ19980. Positions 37-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
GeneTreeiENSGT00390000013481.
HOGENOMiHOG000221222.
InParanoidiQ19980.
KOiK01495.
OMAiVIVVTEC.
OrthoDBiEOG77DJ6T.
PhylomeDBiQ19980.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI
60 70 80 90 100
IQHVGEDINR QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE
110 120 130 140 150
MVIVKDIEMF SLCEHHLVPF MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR
160 170 180 190 200
LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA SHMCMVMRGV QKINASTTTS
210 220
CMLGVFRDDP KTREEFLNLI NKR
Length:223
Mass (Da):25,132
Last modified:November 1, 1997 - v1
Checksum:iB6584D6CBA6FA003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1.
PIRiT21669.
RefSeqiNP_505710.1. NM_073309.5.
UniGeneiCel.3775.

Genome annotation databases

EnsemblMetazoaiF32G8.6; F32G8.6; WBGene00000298.
GeneIDi179472.
KEGGicel:CELE_F32G8.6.
UCSCiF32G8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1.
PIRiT21669.
RefSeqiNP_505710.1. NM_073309.5.
UniGeneiCel.3775.

3D structure databases

ProteinModelPortaliQ19980.
SMRiQ19980. Positions 37-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44501. 3 interactions.
DIPiDIP-24416N.
IntActiQ19980. 10 interactions.
MINTiMINT-1077330.
STRINGi6239.F32G8.6.

Proteomic databases

PaxDbiQ19980.
PRIDEiQ19980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32G8.6; F32G8.6; WBGene00000298.
GeneIDi179472.
KEGGicel:CELE_F32G8.6.
UCSCiF32G8.6. c. elegans.

Organism-specific databases

CTDi179472.
WormBaseiF32G8.6; CE05795; WBGene00000298; cat-4.

Phylogenomic databases

eggNOGiCOG0302.
GeneTreeiENSGT00390000013481.
HOGENOMiHOG000221222.
InParanoidiQ19980.
KOiK01495.
OMAiVIVVTEC.
OrthoDBiEOG77DJ6T.
PhylomeDBiQ19980.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
ReactomeiREACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Miscellaneous databases

NextBioi905542.
PROiQ19980.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGCH1_CAEEL
AccessioniPrimary (citable) accession number: Q19980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.