Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q19980

- GCH1_CAEEL

UniProt

Q19980 - GCH1_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase 1

Gene

cat-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131ZincBy similarity
Metal bindingi116 – 1161ZincBy similarity
Metal bindingi184 – 1841ZincBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. dopamine biosynthetic process Source: WormBase
  3. melanin biosynthetic process Source: WormBase
  4. tetrahydrobiopterin biosynthetic process Source: UniProtKB-KW
  5. tetrahydrofolate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:cat-4
ORF Names:F32G8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF32G8.6; CE05795; WBGene00000298; cat-4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223GTP cyclohydrolase 1PRO_0000119480Add
BLAST

Proteomic databases

PaxDbiQ19980.
PRIDEiQ19980.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
T07D4.2Q223062EBI-311852,EBI-311847
tag-80H2KYL02EBI-311852,EBI-2916517

Protein-protein interaction databases

BioGridi44501. 3 interactions.
DIPiDIP-24416N.
IntActiQ19980. 10 interactions.
MINTiMINT-1077330.
STRINGi6239.F32G8.6.

Structurei

3D structure databases

ProteinModelPortaliQ19980.
SMRiQ19980. Positions 37-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0302.
GeneTreeiENSGT00390000013481.
HOGENOMiHOG000221222.
InParanoidiQ19980.
KOiK01495.
OMAiVYSHCEH.
OrthoDBiEOG77DJ6T.
PhylomeDBiQ19980.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19980-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI
60 70 80 90 100
IQHVGEDINR QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE
110 120 130 140 150
MVIVKDIEMF SLCEHHLVPF MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR
160 170 180 190 200
LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA SHMCMVMRGV QKINASTTTS
210 220
CMLGVFRDDP KTREEFLNLI NKR
Length:223
Mass (Da):25,132
Last modified:November 1, 1997 - v1
Checksum:iB6584D6CBA6FA003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1.
PIRiT21669.
RefSeqiNP_505710.1. NM_073309.5.
UniGeneiCel.3775.

Genome annotation databases

EnsemblMetazoaiF32G8.6; F32G8.6; WBGene00000298.
GeneIDi179472.
KEGGicel:CELE_F32G8.6.
UCSCiF32G8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1 .
PIRi T21669.
RefSeqi NP_505710.1. NM_073309.5.
UniGenei Cel.3775.

3D structure databases

ProteinModelPortali Q19980.
SMRi Q19980. Positions 37-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44501. 3 interactions.
DIPi DIP-24416N.
IntActi Q19980. 10 interactions.
MINTi MINT-1077330.
STRINGi 6239.F32G8.6.

Proteomic databases

PaxDbi Q19980.
PRIDEi Q19980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F32G8.6 ; F32G8.6 ; WBGene00000298 .
GeneIDi 179472.
KEGGi cel:CELE_F32G8.6.
UCSCi F32G8.6. c. elegans.

Organism-specific databases

CTDi 179472.
WormBasei F32G8.6 ; CE05795 ; WBGene00000298 ; cat-4.

Phylogenomic databases

eggNOGi COG0302.
GeneTreei ENSGT00390000013481.
HOGENOMi HOG000221222.
InParanoidi Q19980.
KOi K01495.
OMAi VYSHCEH.
OrthoDBi EOG77DJ6T.
PhylomeDBi Q19980.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
Reactomei REACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Miscellaneous databases

NextBioi 905542.
PROi Q19980.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGCH1_CAEEL
AccessioniPrimary (citable) accession number: Q19980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3