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Q19980

- GCH1_CAEEL

UniProt

Q19980 - GCH1_CAEEL

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Protein
GTP cyclohydrolase 1
Gene
cat-4, F32G8.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131Zinc By similarity
Metal bindingi116 – 1161Zinc By similarity
Metal bindingi184 – 1841Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. dopamine biosynthetic process Source: WormBase
  3. melanin biosynthetic process Source: WormBase
  4. tetrahydrobiopterin biosynthetic process Source: UniProtKB-KW
  5. tetrahydrofolate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:cat-4
ORF Names:F32G8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF32G8.6; CE05795; WBGene00000298; cat-4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223GTP cyclohydrolase 1UniRule annotation
PRO_0000119480Add
BLAST

Proteomic databases

PaxDbiQ19980.
PRIDEiQ19980.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
T07D4.2Q223062EBI-311852,EBI-311847
tag-80H2KYL02EBI-311852,EBI-2916517

Protein-protein interaction databases

BioGridi44501. 3 interactions.
DIPiDIP-24416N.
IntActiQ19980. 10 interactions.
MINTiMINT-1077330.
STRINGi6239.F32G8.6.

Structurei

3D structure databases

ProteinModelPortaliQ19980.
SMRiQ19980. Positions 37-220.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
GeneTreeiENSGT00390000013481.
HOGENOMiHOG000221222.
InParanoidiQ19980.
KOiK01495.
OMAiVYSHCEH.
OrthoDBiEOG77DJ6T.
PhylomeDBiQ19980.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19980-1 [UniParc]FASTAAdd to Basket

« Hide

MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI    50
IQHVGEDINR QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE 100
MVIVKDIEMF SLCEHHLVPF MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR 150
LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA SHMCMVMRGV QKINASTTTS 200
CMLGVFRDDP KTREEFLNLI NKR 223
Length:223
Mass (Da):25,132
Last modified:November 1, 1997 - v1
Checksum:iB6584D6CBA6FA003
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1.
PIRiT21669.
RefSeqiNP_505710.1. NM_073309.5.
UniGeneiCel.3775.

Genome annotation databases

EnsemblMetazoaiF32G8.6; F32G8.6; WBGene00000298.
GeneIDi179472.
KEGGicel:CELE_F32G8.6.
UCSCiF32G8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72509 Genomic DNA. Translation: CAA96650.1 .
PIRi T21669.
RefSeqi NP_505710.1. NM_073309.5.
UniGenei Cel.3775.

3D structure databases

ProteinModelPortali Q19980.
SMRi Q19980. Positions 37-220.
ModBasei Search...

Protein-protein interaction databases

BioGridi 44501. 3 interactions.
DIPi DIP-24416N.
IntActi Q19980. 10 interactions.
MINTi MINT-1077330.
STRINGi 6239.F32G8.6.

Proteomic databases

PaxDbi Q19980.
PRIDEi Q19980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F32G8.6 ; F32G8.6 ; WBGene00000298 .
GeneIDi 179472.
KEGGi cel:CELE_F32G8.6.
UCSCi F32G8.6. c. elegans.

Organism-specific databases

CTDi 179472.
WormBasei F32G8.6 ; CE05795 ; WBGene00000298 ; cat-4.

Phylogenomic databases

eggNOGi COG0302.
GeneTreei ENSGT00390000013481.
HOGENOMi HOG000221222.
InParanoidi Q19980.
KOi K01495.
OMAi VYSHCEH.
OrthoDBi EOG77DJ6T.
PhylomeDBi Q19980.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
Reactomei REACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

Miscellaneous databases

NextBioi 905542.
PROi Q19980.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGCH1_CAEEL
AccessioniPrimary (citable) accession number: Q19980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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