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Q19980

- GCH1_CAEEL

UniProt

Q19980 - GCH1_CAEEL

Protein

GTP cyclohydrolase 1

Gene

cat-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi113 – 1131ZincBy similarity
    Metal bindingi116 – 1161ZincBy similarity
    Metal bindingi184 – 1841ZincBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. dopamine biosynthetic process Source: WormBase
    3. melanin biosynthetic process Source: WormBase
    4. tetrahydrobiopterin biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Tetrahydrobiopterin biosynthesis

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1 (EC:3.5.4.16)
    Alternative name(s):
    GTP cyclohydrolase I
    Short name:
    GTP-CH-I
    Gene namesi
    Name:cat-4
    ORF Names:F32G8.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF32G8.6; CE05795; WBGene00000298; cat-4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223GTP cyclohydrolase 1PRO_0000119480Add
    BLAST

    Proteomic databases

    PaxDbiQ19980.
    PRIDEiQ19980.

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    T07D4.2Q223062EBI-311852,EBI-311847
    tag-80H2KYL02EBI-311852,EBI-2916517

    Protein-protein interaction databases

    BioGridi44501. 3 interactions.
    DIPiDIP-24416N.
    IntActiQ19980. 10 interactions.
    MINTiMINT-1077330.
    STRINGi6239.F32G8.6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ19980.
    SMRiQ19980. Positions 37-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0302.
    GeneTreeiENSGT00390000013481.
    HOGENOMiHOG000221222.
    InParanoidiQ19980.
    KOiK01495.
    OMAiVYSHCEH.
    OrthoDBiEOG77DJ6T.
    PhylomeDBiQ19980.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q19980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI    50
    IQHVGEDINR QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE 100
    MVIVKDIEMF SLCEHHLVPF MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR 150
    LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA SHMCMVMRGV QKINASTTTS 200
    CMLGVFRDDP KTREEFLNLI NKR 223
    Length:223
    Mass (Da):25,132
    Last modified:November 1, 1997 - v1
    Checksum:iB6584D6CBA6FA003
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72509 Genomic DNA. Translation: CAA96650.1.
    PIRiT21669.
    RefSeqiNP_505710.1. NM_073309.5.
    UniGeneiCel.3775.

    Genome annotation databases

    EnsemblMetazoaiF32G8.6; F32G8.6; WBGene00000298.
    GeneIDi179472.
    KEGGicel:CELE_F32G8.6.
    UCSCiF32G8.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72509 Genomic DNA. Translation: CAA96650.1 .
    PIRi T21669.
    RefSeqi NP_505710.1. NM_073309.5.
    UniGenei Cel.3775.

    3D structure databases

    ProteinModelPortali Q19980.
    SMRi Q19980. Positions 37-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44501. 3 interactions.
    DIPi DIP-24416N.
    IntActi Q19980. 10 interactions.
    MINTi MINT-1077330.
    STRINGi 6239.F32G8.6.

    Proteomic databases

    PaxDbi Q19980.
    PRIDEi Q19980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F32G8.6 ; F32G8.6 ; WBGene00000298 .
    GeneIDi 179472.
    KEGGi cel:CELE_F32G8.6.
    UCSCi F32G8.6. c. elegans.

    Organism-specific databases

    CTDi 179472.
    WormBasei F32G8.6 ; CE05795 ; WBGene00000298 ; cat-4.

    Phylogenomic databases

    eggNOGi COG0302.
    GeneTreei ENSGT00390000013481.
    HOGENOMi HOG000221222.
    InParanoidi Q19980.
    KOi K01495.
    OMAi VYSHCEH.
    OrthoDBi EOG77DJ6T.
    PhylomeDBi Q19980.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    Reactomei REACT_183242. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

    Miscellaneous databases

    NextBioi 905542.
    PROi Q19980.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGCH1_CAEEL
    AccessioniPrimary (citable) accession number: Q19980
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3