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Q19980 (GCH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:cat-4
ORF Names:F32G8.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration. HAMAP-Rule MF_00223

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CELE_F45E4.3H2KYL02EBI-311852,EBI-2916517
T07D4.2Q223062EBI-311852,EBI-311847

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119480

Sites

Metal binding1131Zinc By similarity
Metal binding1161Zinc By similarity
Metal binding1841Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q19980 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B6584D6CBA6FA003

FASTA22325,132
        10         20         30         40         50         60 
MSRIENESGF LSSDAASVGS EDDKVEMKKR NGTIPKEDHL KSMCNAYQSI IQHVGEDINR 

        70         80         90        100        110        120 
QGLLKTPERA AKAMMAFTKG YDDQLDELLN EAVFDEDHDE MVIVKDIEMF SLCEHHLVPF 

       130        140        150        160        170        180 
MGKVHIGYIP NKKVLGLSKL ARIVEMFSRR LQVQERLTKQ IATAMVQAVQ PSGVAVVIEA 

       190        200        210        220 
SHMCMVMRGV QKINASTTTS CMLGVFRDDP KTREEFLNLI NKR 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72509 Genomic DNA. Translation: CAA96650.1.
PIRT21669.
RefSeqNP_505710.1. NM_073309.5.
UniGeneCel.3775.

3D structure databases

ProteinModelPortalQ19980.
SMRQ19980. Positions 37-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44501. 3 interactions.
DIPDIP-24416N.
IntActQ19980. 10 interactions.
MINTMINT-1077330.
STRING6239.F32G8.6.

Proteomic databases

PaxDbQ19980.
PRIDEQ19980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF32G8.6; F32G8.6; F32G8.6.
GeneID179472.
KEGGcel:CELE_F32G8.6.
UCSCF32G8.6. c. elegans.

Organism-specific databases

CTD179472.
WormBaseF32G8.6; CE05795; WBGene00000298; cat-4.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
InParanoidQ19980.
KOK01495.
OMAVIVVTEC.
OrthoDBEOG77DJ6T.
PhylomeDBQ19980.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio905542.
PROQ19980.

Entry information

Entry nameGCH1_CAEEL
AccessionPrimary (citable) accession number: Q19980
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase