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Protein
Submitted name:

AQuaPorin or aquaglyceroporin related

Gene

aqp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • defense response to Gram-negative bacterium Source: WormBase
  • glycerol transport Source: WormBase
  • innate immune response Source: WormBase
  • ion transmembrane transport Source: GO_Central
  • urea transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
AQuaPorin or aquaglyceroporin relatedImported
Gene namesi
Name:aqp-1Imported
ORF Names:CELE_F32A5.5Imported, F32A5.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF32A5.5a; CE29304; WBGene00000169; aqp-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5425HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8722HelicalSequence analysisAdd
BLAST
Transmembranei108 – 13326HelicalSequence analysisAdd
BLAST
Transmembranei171 – 18919HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22323HelicalSequence analysisAdd
BLAST
Transmembranei251 – 27020HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: WormBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ19949.
PaxDbiQ19949.
PRIDEiQ19949.

Expressioni

Gene expression databases

ExpressionAtlasiQ19949. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F32A5.5a.

Structurei

3D structure databases

ProteinModelPortaliQ19949.
SMRiQ19949. Positions 33-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ19949.
KOiK09886.
OMAiDERNQIP.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ19949.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRFIRKIM TAEEDTLPER LRFHGVHTNI LARNLIAEFF GTFLLCFIGL
60 70 80 90 100
SIVFQFHAGG GKTTEWIGVN IGWGFAIMFA VMATARMSGG HLNPAVSLLL
110 120 130 140 150
WSLGHLKLAW VPLYAIAQTA GAFVASLGMY SYYYEQFNAF DGGNRTILGA
160 170 180 190 200
TGTAGCFASY PSPNLGVWGP YIDQCVGTGV LAYFLCVVID ERNQIPKIWH
210 220 230 240 250
PMFFGFLVMM IGTGFGMNIG YPINPARDLG PRLFSYFIYG PGVFHSPYPN
260 270 280 290 300
YWLAPAIAPF VGALVGGWFY HFSLGMHNPD IEEADDIFVQ QPPKSVEQQK

LLQA
Length:304
Mass (Da):33,691
Last modified:December 1, 2001 - v2
Checksum:i9DCDBA8454F0E2CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD66276.1.
RefSeqiNP_495510.1. NM_063109.5.
UniGeneiCel.15262.

Genome annotation databases

EnsemblMetazoaiF32A5.5a; F32A5.5a; WBGene00000169.
GeneIDi174190.
KEGGicel:CELE_F32A5.5.
UCSCiF32A5.5a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD66276.1.
RefSeqiNP_495510.1. NM_063109.5.
UniGeneiCel.15262.

3D structure databases

ProteinModelPortaliQ19949.
SMRiQ19949. Positions 33-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F32A5.5a.

Proteomic databases

EPDiQ19949.
PaxDbiQ19949.
PRIDEiQ19949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32A5.5a; F32A5.5a; WBGene00000169.
GeneIDi174190.
KEGGicel:CELE_F32A5.5.
UCSCiF32A5.5a. c. elegans.

Organism-specific databases

CTDi174190.
WormBaseiF32A5.5a; CE29304; WBGene00000169; aqp-1.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ19949.
KOiK09886.
OMAiDERNQIP.
OrthoDBiEOG7J9VPP.
PhylomeDBiQ19949.

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Gene expression databases

ExpressionAtlasiQ19949. baseline.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ19949_CAEEL
AccessioniPrimary (citable) accession number: Q19949
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.