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Protein
Submitted name:

AQuaPorin or aquaglyceroporin related

Gene

aqp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • defense response to Gram-negative bacterium Source: WormBase
  • glycerol transport Source: WormBase
  • innate immune response Source: WormBase
  • ion transmembrane transport Source: GO_Central
  • urea transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
AQuaPorin or aquaglyceroporin relatedImported
Gene namesi
Name:aqp-1Imported
ORF Names:CELE_F32A5.5Imported, F32A5.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF32A5.5a; CE29304; WBGene00000169; aqp-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 54HelicalSequence analysisAdd BLAST25
Transmembranei66 – 87HelicalSequence analysisAdd BLAST22
Transmembranei108 – 133HelicalSequence analysisAdd BLAST26
Transmembranei171 – 189HelicalSequence analysisAdd BLAST19
Transmembranei201 – 223HelicalSequence analysisAdd BLAST23
Transmembranei251 – 270HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • basolateral plasma membrane Source: WormBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ19949.
PaxDbiQ19949.
PeptideAtlasiQ19949.

Expressioni

Gene expression databases

BgeeiWBGene00000169.
ExpressionAtlasiQ19949. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.F32A5.5a.

Structurei

3D structure databases

ProteinModelPortaliQ19949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ19949.
KOiK09886.
OMAiDERNQIP.
OrthoDBiEOG091G0FMS.
PhylomeDBiQ19949.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRFIRKIM TAEEDTLPER LRFHGVHTNI LARNLIAEFF GTFLLCFIGL
60 70 80 90 100
SIVFQFHAGG GKTTEWIGVN IGWGFAIMFA VMATARMSGG HLNPAVSLLL
110 120 130 140 150
WSLGHLKLAW VPLYAIAQTA GAFVASLGMY SYYYEQFNAF DGGNRTILGA
160 170 180 190 200
TGTAGCFASY PSPNLGVWGP YIDQCVGTGV LAYFLCVVID ERNQIPKIWH
210 220 230 240 250
PMFFGFLVMM IGTGFGMNIG YPINPARDLG PRLFSYFIYG PGVFHSPYPN
260 270 280 290 300
YWLAPAIAPF VGALVGGWFY HFSLGMHNPD IEEADDIFVQ QPPKSVEQQK

LLQA
Length:304
Mass (Da):33,691
Last modified:December 1, 2001 - v2
Checksum:i9DCDBA8454F0E2CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD66276.1.
RefSeqiNP_495510.1. NM_063109.5.
UniGeneiCel.15262.

Genome annotation databases

EnsemblMetazoaiF32A5.5a; F32A5.5a; WBGene00000169.
GeneIDi174190.
KEGGicel:CELE_F32A5.5.
UCSCiF32A5.5a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD66276.1.
RefSeqiNP_495510.1. NM_063109.5.
UniGeneiCel.15262.

3D structure databases

ProteinModelPortaliQ19949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F32A5.5a.

Proteomic databases

EPDiQ19949.
PaxDbiQ19949.
PeptideAtlasiQ19949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32A5.5a; F32A5.5a; WBGene00000169.
GeneIDi174190.
KEGGicel:CELE_F32A5.5.
UCSCiF32A5.5a. c. elegans.

Organism-specific databases

CTDi174190.
WormBaseiF32A5.5a; CE29304; WBGene00000169; aqp-1.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ19949.
KOiK09886.
OMAiDERNQIP.
OrthoDBiEOG091G0FMS.
PhylomeDBiQ19949.

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Gene expression databases

BgeeiWBGene00000169.
ExpressionAtlasiQ19949. differential.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ19949_CAEEL
AccessioniPrimary (citable) accession number: Q19949
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.