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Q19905 (UGDH_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase

Short name=UDP-Glc dehydrogenase
Short name=UDP-GlcDH
Short name=UDPGDH
EC=1.1.1.22
Alternative name(s):
Squashed vulva protein 4
Gene names
Name:sqv-4
ORF Names:F29F11.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Tissue specificity

Expressed in the vulva and in oocytes.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-320696,EBI-320696

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481UDP-glucose 6-dehydrogenase
PRO_0000074063

Regions

Nucleotide binding16 – 216NAD By similarity
Nucleotide binding94 – 985NAD By similarity
Nucleotide binding135 – 1362NAD By similarity
Nucleotide binding283 – 2864NAD By similarity
Region168 – 1725Substrate binding By similarity
Region227 – 2348Substrate binding By similarity
Region267 – 28014Substrate binding By similarity
Region345 – 3462Substrate binding By similarity

Sites

Active site2831Nucleophile By similarity
Binding site411NAD By similarity
Binding site461NAD By similarity
Binding site1721NAD By similarity
Binding site3531NAD By similarity
Binding site4471Substrate By similarity

Secondary structure

................................................................................ 481
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q19905 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E789DC5D6679531

FASTA48152,755
        10         20         30         40         50         60 
MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW NSDKLPIYEP 

        70         80         90        100        110        120 
GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM YGRGKGMAPD LKYVESVSRT 

       130        140        150        160        170        180 
IAQYAGGPKI VVEKSTVPVK AAESIGCILR EAQKNNENLK FQVLSNPEFL AEGTAMKDLA 

       190        200        210        220        230        240 
NPDRVLIGGE SSPEGLQAVA ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS 

       250        260        270        280        290        300 
INSISAVCEA TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL 

       310        320        330        340        350        360 
PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG DTRESSAIHV 

       370        380        390        400        410        420 
IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI TVESDPYAAA RGAHAIVVLT 

       430        440        450        460        470        480 
EWDEFVELNY SQIHNDMQHP AAIFDGRLIL DQKALREIGF RTFAIGTSPD QAYNLFGTAG 


Y 

« Hide

References

« Hide 'large scale' references
[1]"The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated."
Hwang H.Y., Horvitz H.R.
Proc. Natl. Acad. Sci. U.S.A. 99:14224-14229(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Crystal structure of caenorhabditis elegans udp-glucose dehydrogenase."
New York structural genomix research consortium (NYSGXRC)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.
PIRT21550.
RefSeqNP_505730.1. NM_073329.7.
UniGeneCel.19769.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2O3JX-ray1.88A/B/C1-481[»]
ProteinModelPortalQ19905.
SMRQ19905. Positions 3-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44513. 6 interactions.
DIPDIP-24290N.
IntActQ19905. 17 interactions.
MINTMINT-1063665.
STRING6239.F29F11.1.2.

Proteomic databases

PaxDbQ19905.
PRIDEQ19905.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF29F11.1; F29F11.1; WBGene00005022.
GeneID179484.
KEGGcel:CELE_F29F11.1.
UCSCF29F11.1.1. c. elegans.

Organism-specific databases

CTD179484.
WormBaseF29F11.1; CE05767; WBGene00005022; sqv-4.

Phylogenomic databases

eggNOGCOG1004.
GeneTreeENSGT00390000015355.
HOGENOMHOG000153773.
InParanoidQ19905.
KOK00012.
OMAVELNTWQ.
PhylomeDBQ19905.

Enzyme and pathway databases

BRENDA1.1.1.22. 1045.
UniPathwayUPA00038; UER00491.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ19905.
NextBio905594.
PROQ19905.

Entry information

Entry nameUGDH_CAEEL
AccessionPrimary (citable) accession number: Q19905
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase