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Q19905

- UGDH_CAEEL

UniProt

Q19905 - UGDH_CAEEL

Protein

UDP-glucose 6-dehydrogenase

Gene

sqv-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411NADBy similarity
    Binding sitei46 – 461NADBy similarity
    Binding sitei172 – 1721NADBy similarity
    Active sitei283 – 2831NucleophileBy similarity
    Binding sitei353 – 3531NADBy similarity
    Binding sitei447 – 4471SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 216NADBy similarity
    Nucleotide bindingi94 – 985NADBy similarity
    Nucleotide bindingi135 – 1362NADBy similarity
    Nucleotide bindingi283 – 2864NADBy similarity

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. NAD binding Source: InterPro
    3. UDP-glucose 6-dehydrogenase activity Source: WormBase

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: WormBase
    2. glycosaminoglycan biosynthetic process Source: WormBase
    3. morphogenesis of an epithelium Source: WormBase
    4. oviposition Source: WormBase
    5. reproduction Source: WormBase
    6. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
    7. vulval development Source: WormBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.1.1.22. 1045.
    UniPathwayiUPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Alternative name(s):
    Squashed vulva protein 4
    Gene namesi
    Name:sqv-4
    ORF Names:F29F11.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF29F11.1; CE05767; WBGene00005022; sqv-4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481UDP-glucose 6-dehydrogenasePRO_0000074063Add
    BLAST

    Proteomic databases

    PaxDbiQ19905.
    PRIDEiQ19905.

    Expressioni

    Tissue specificityi

    Expressed in the vulva and in oocytes.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-320696,EBI-320696

    Protein-protein interaction databases

    BioGridi44513. 6 interactions.
    DIPiDIP-24290N.
    IntActiQ19905. 17 interactions.
    MINTiMINT-1063665.
    STRINGi6239.F29F11.1.2.

    Structurei

    Secondary structure

    1
    481
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 155
    Helixi21 – 3111
    Beta strandi35 – 406
    Helixi44 – 507
    Beta strandi52 – 543
    Helixi62 – 698
    Turni71 – 733
    Beta strandi74 – 785
    Helixi80 – 867
    Beta strandi88 – 925
    Turni103 – 1075
    Helixi112 – 12413
    Beta strandi129 – 1335
    Helixi141 – 15212
    Beta strandi161 – 1655
    Helixi175 – 1806
    Beta strandi185 – 1895
    Helixi193 – 20715
    Helixi212 – 2143
    Beta strandi215 – 2195
    Helixi220 – 25132
    Helixi255 – 2639
    Turni266 – 2683
    Beta strandi270 – 2723
    Beta strandi281 – 2833
    Helixi284 – 29714
    Helixi301 – 32828
    Turni329 – 3313
    Beta strandi337 – 3415
    Beta strandi344 – 3463
    Helixi356 – 36611
    Beta strandi370 – 3745
    Beta strandi376 – 3783
    Helixi380 – 39011
    Helixi393 – 3997
    Beta strandi400 – 4056
    Helixi406 – 4105
    Beta strandi414 – 4185
    Helixi423 – 4253
    Helixi430 – 4367
    Beta strandi442 – 4487
    Helixi452 – 4587
    Beta strandi461 – 4644

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2O3JX-ray1.88A/B/C1-481[»]
    ProteinModelPortaliQ19905.
    SMRiQ19905. Positions 3-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ19905.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni168 – 1725Substrate bindingBy similarity
    Regioni227 – 2348Substrate bindingBy similarity
    Regioni267 – 28014Substrate bindingBy similarityAdd
    BLAST
    Regioni345 – 3462Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    GeneTreeiENSGT00390000015355.
    HOGENOMiHOG000153773.
    InParanoidiQ19905.
    KOiK00012.
    OMAiVELNTWQ.
    PhylomeDBiQ19905.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q19905-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW    50
    NSDKLPIYEP GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM 100
    YGRGKGMAPD LKYVESVSRT IAQYAGGPKI VVEKSTVPVK AAESIGCILR 150
    EAQKNNENLK FQVLSNPEFL AEGTAMKDLA NPDRVLIGGE SSPEGLQAVA 200
    ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS INSISAVCEA 250
    TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL 300
    PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG 350
    DTRESSAIHV IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI 400
    TVESDPYAAA RGAHAIVVLT EWDEFVELNY SQIHNDMQHP AAIFDGRLIL 450
    DQKALREIGF RTFAIGTSPD QAYNLFGTAG Y 481
    Length:481
    Mass (Da):52,755
    Last modified:November 1, 1996 - v1
    Checksum:i4E789DC5D6679531
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY147932 mRNA. Translation: AAN39842.1.
    Z73974 Genomic DNA. Translation: CAA98269.1.
    PIRiT21550.
    RefSeqiNP_505730.1. NM_073329.7.
    UniGeneiCel.19769.

    Genome annotation databases

    EnsemblMetazoaiF29F11.1; F29F11.1; WBGene00005022.
    GeneIDi179484.
    KEGGicel:CELE_F29F11.1.
    UCSCiF29F11.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY147932 mRNA. Translation: AAN39842.1 .
    Z73974 Genomic DNA. Translation: CAA98269.1 .
    PIRi T21550.
    RefSeqi NP_505730.1. NM_073329.7.
    UniGenei Cel.19769.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2O3J X-ray 1.88 A/B/C 1-481 [» ]
    ProteinModelPortali Q19905.
    SMRi Q19905. Positions 3-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44513. 6 interactions.
    DIPi DIP-24290N.
    IntActi Q19905. 17 interactions.
    MINTi MINT-1063665.
    STRINGi 6239.F29F11.1.2.

    Proteomic databases

    PaxDbi Q19905.
    PRIDEi Q19905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F29F11.1 ; F29F11.1 ; WBGene00005022 .
    GeneIDi 179484.
    KEGGi cel:CELE_F29F11.1.
    UCSCi F29F11.1.1. c. elegans.

    Organism-specific databases

    CTDi 179484.
    WormBasei F29F11.1 ; CE05767 ; WBGene00005022 ; sqv-4.

    Phylogenomic databases

    eggNOGi COG1004.
    GeneTreei ENSGT00390000015355.
    HOGENOMi HOG000153773.
    InParanoidi Q19905.
    KOi K00012.
    OMAi VELNTWQ.
    PhylomeDBi Q19905.

    Enzyme and pathway databases

    UniPathwayi UPA00038 ; UER00491 .
    BRENDAi 1.1.1.22. 1045.

    Miscellaneous databases

    EvolutionaryTracei Q19905.
    NextBioi 905594.
    PROi Q19905.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated."
      Hwang H.Y., Horvitz H.R.
      Proc. Natl. Acad. Sci. U.S.A. 99:14224-14229(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Crystal structure of caenorhabditis elegans udp-glucose dehydrogenase."
      New York structural genomix research consortium (NYSGXRC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

    Entry informationi

    Entry nameiUGDH_CAEEL
    AccessioniPrimary (citable) accession number: Q19905
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3