UDP-glucose 6-dehydrogenase - Caenorhabditis elegans

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Reviewed, UniProtKB/Swiss-Prot Q19905 (UGDH_CAEEL)

Last modified November 25, 2008. Version 61. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22
Alternative name(s):
    Squashed vulva protein 4

Gene names

Name:	sqv-4
ORF Names:	F29F11.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Catalytic activity	UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-glucuronate biosynthesis; UDP-glucuronate from UDP-glucose: step 1/1.
Tissue specificity	Expressed in the vulva and in oocytes.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

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Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase oviposition Inferred from mutant phenotype. Source: WormBase oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW vulval development Inferred from mutant phenotype. Source: WormBase
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
itself		1	EBI-320696,EBI-320696
	Q21813	1	EBI-320696,EBI-320703
smo-1	P55853	1	EBI-320696,EBI-313647

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 481

481

UDP-glucose 6-dehydrogenase

PRO_0000074063

Regions

Nucleotide binding

11 – 28

NAD By similarity

Region

169 – 172

Substrate binding By similarity

Sites

Active site

283

Nucleophile By similarity

Binding site

NAD By similarity

Binding site

NAD By similarity

Binding site

NAD By similarity

Binding site

136

NAD; via amide nitrogen By similarity

Binding site

172

NAD By similarity

Binding site

227

Substrate By similarity

Binding site

280

Substrate; via amide nitrogen By similarity

Binding site

286

NAD By similarity

Binding site

346

Substrate By similarity

Binding site

353

NAD By similarity

Secondary structure

481

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q19905-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E789DC5D6679531
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FASTA

481

52,755

        10         20         30         40         50         60 
MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW NSDKLPIYEP 

        70         80         90        100        110        120 
GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM YGRGKGMAPD LKYVESVSRT 

       130        140        150        160        170        180 
IAQYAGGPKI VVEKSTVPVK AAESIGCILR EAQKNNENLK FQVLSNPEFL AEGTAMKDLA 

       190        200        210        220        230        240 
NPDRVLIGGE SSPEGLQAVA ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS 

       250        260        270        280        290        300 
INSISAVCEA TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL 

       310        320        330        340        350        360 
PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG DTRESSAIHV 

       370        380        390        400        410        420 
IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI TVESDPYAAA RGAHAIVVLT 

       430        440        450        460        470        480 
EWDEFVELNY SQIHNDMQHP AAIFDGRLIL DQKALREIGF RTFAIGTSPD QAYNLFGTAG 


Y

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated." Hwang H.Y., Horvitz H.R. Proc. Natl. Acad. Sci. U.S.A. 99:14224-14229(2002) [PubMed: 12391315] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

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Cross-references

Sequence databases

AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.

PIR

T21550.

RefSeq

NP_505730.1.

UniGene

Cel.19769

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2O3J	X-ray	1.88	A/B/C	1-481	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:24290N.

IntAct

Q19905.

Genome annotation databases

Ensembl

F29F11.1. Caenorhabditis elegans. [Contig view]

GeneID

179484.

KEGG

cel:F29F11.1.

Organism-specific databases

WormBase

WBGene00005022. sqv-4.

WormPep

F29F11.1. CE05767. [WorfDB]

Gene expression databases

ArrayExpress

Q19905.

Family and domain databases

InterPro

IPR016040. NAD(P)-bd.
IPR017476. Nucleotide_sugar_DH.
IPR014027. UDP-Glc/GDP-Man_DHase_C.
IPR014026. UDP-Glc/GDP-Man_DHase_dimer.
IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732. UDP-Glc/GDP-Man_DHase_N.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.

PANTHER

PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.

Pfam

PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

905594.

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Entry information

Entry name

UGDH_CAEEL

Accession

Primary (citable) accession number: Q19905

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents