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Protein

UDP-glucose 6-dehydrogenase

Gene

sqv-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (sqv-4)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41NADBy similarity1
Binding sitei46NADBy similarity1
Binding sitei172NADBy similarity1
Binding sitei267SubstrateBy similarity1
Active sitei283NucleophileBy similarity1
Binding sitei353NADBy similarity1
Binding sitei447SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21NADBy similarity6
Nucleotide bindingi94 – 98NADBy similarity5
Nucleotide bindingi135 – 136NADBy similarity2
Nucleotide bindingi283 – 286NADBy similarity4

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: WormBase

GO - Biological processi

  • carbohydrate metabolic process Source: GO_Central
  • embryo development ending in birth or egg hatching Source: WormBase
  • glycosaminoglycan biosynthetic process Source: WormBase
  • morphogenesis of an epithelium Source: WormBase
  • oviposition Source: WormBase
  • reproduction Source: WormBase
  • UDP-glucuronate biosynthetic process Source: GO_Central
  • vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.1.1.22. 1045.
ReactomeiR-CEL-173599. Formation of the active cofactor, UDP-glucuronate.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Alternative name(s):
Squashed vulva protein 4
Gene namesi
Name:sqv-4
ORF Names:F29F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF29F11.1; CE05767; WBGene00005022; sqv-4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • cytosol Source: GO_Central
  • nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740631 – 481UDP-glucose 6-dehydrogenaseAdd BLAST481

Proteomic databases

EPDiQ19905.
PaxDbiQ19905.
PeptideAtlasiQ19905.
PRIDEiQ19905.

Expressioni

Tissue specificityi

Expressed in the vulva and in oocytes.

Gene expression databases

BgeeiWBGene00005022.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-320696,EBI-320696

Protein-protein interaction databases

BioGridi44513. 6 interactors.
DIPiDIP-24290N.
IntActiQ19905. 18 interactors.
MINTiMINT-1063665.
STRINGi6239.F29F11.1.2.

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Helixi21 – 31Combined sources11
Beta strandi35 – 40Combined sources6
Helixi44 – 50Combined sources7
Beta strandi52 – 54Combined sources3
Helixi62 – 69Combined sources8
Turni71 – 73Combined sources3
Beta strandi74 – 78Combined sources5
Helixi80 – 86Combined sources7
Beta strandi88 – 92Combined sources5
Turni103 – 107Combined sources5
Helixi112 – 124Combined sources13
Beta strandi129 – 133Combined sources5
Helixi141 – 152Combined sources12
Beta strandi161 – 165Combined sources5
Helixi175 – 180Combined sources6
Beta strandi185 – 189Combined sources5
Helixi193 – 207Combined sources15
Helixi212 – 214Combined sources3
Beta strandi215 – 219Combined sources5
Helixi220 – 251Combined sources32
Helixi255 – 263Combined sources9
Turni266 – 268Combined sources3
Beta strandi270 – 272Combined sources3
Beta strandi281 – 283Combined sources3
Helixi284 – 297Combined sources14
Helixi301 – 328Combined sources28
Turni329 – 331Combined sources3
Beta strandi337 – 341Combined sources5
Beta strandi344 – 346Combined sources3
Helixi356 – 366Combined sources11
Beta strandi370 – 374Combined sources5
Beta strandi376 – 378Combined sources3
Helixi380 – 390Combined sources11
Helixi393 – 399Combined sources7
Beta strandi400 – 405Combined sources6
Helixi406 – 410Combined sources5
Beta strandi414 – 418Combined sources5
Helixi423 – 425Combined sources3
Helixi430 – 436Combined sources7
Beta strandi442 – 448Combined sources7
Helixi452 – 458Combined sources7
Beta strandi461 – 464Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O3JX-ray1.88A/B/C1-481[»]
ProteinModelPortaliQ19905.
SMRiQ19905.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ19905.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 172Substrate bindingBy similarity5
Regioni227 – 231Substrate bindingBy similarity5
Regioni274 – 280Substrate bindingBy similarity7
Regioni345 – 346Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666. Eukaryota.
COG1004. LUCA.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
InParanoidiQ19905.
KOiK00012.
OMAiCLAQVGH.
OrthoDBiEOG091G05RK.
PhylomeDBiQ19905.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW
60 70 80 90 100
NSDKLPIYEP GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM
110 120 130 140 150
YGRGKGMAPD LKYVESVSRT IAQYAGGPKI VVEKSTVPVK AAESIGCILR
160 170 180 190 200
EAQKNNENLK FQVLSNPEFL AEGTAMKDLA NPDRVLIGGE SSPEGLQAVA
210 220 230 240 250
ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS INSISAVCEA
260 270 280 290 300
TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL
310 320 330 340 350
PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG
360 370 380 390 400
DTRESSAIHV IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI
410 420 430 440 450
TVESDPYAAA RGAHAIVVLT EWDEFVELNY SQIHNDMQHP AAIFDGRLIL
460 470 480
DQKALREIGF RTFAIGTSPD QAYNLFGTAG Y
Length:481
Mass (Da):52,755
Last modified:November 1, 1996 - v1
Checksum:i4E789DC5D6679531
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.
PIRiT21550.
RefSeqiNP_505730.1. NM_073329.7.
UniGeneiCel.19769.

Genome annotation databases

EnsemblMetazoaiF29F11.1; F29F11.1; WBGene00005022.
GeneIDi179484.
KEGGicel:CELE_F29F11.1.
UCSCiF29F11.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.
PIRiT21550.
RefSeqiNP_505730.1. NM_073329.7.
UniGeneiCel.19769.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O3JX-ray1.88A/B/C1-481[»]
ProteinModelPortaliQ19905.
SMRiQ19905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44513. 6 interactors.
DIPiDIP-24290N.
IntActiQ19905. 18 interactors.
MINTiMINT-1063665.
STRINGi6239.F29F11.1.2.

Proteomic databases

EPDiQ19905.
PaxDbiQ19905.
PeptideAtlasiQ19905.
PRIDEiQ19905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF29F11.1; F29F11.1; WBGene00005022.
GeneIDi179484.
KEGGicel:CELE_F29F11.1.
UCSCiF29F11.1.1. c. elegans.

Organism-specific databases

CTDi179484.
WormBaseiF29F11.1; CE05767; WBGene00005022; sqv-4.

Phylogenomic databases

eggNOGiKOG2666. Eukaryota.
COG1004. LUCA.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
InParanoidiQ19905.
KOiK00012.
OMAiCLAQVGH.
OrthoDBiEOG091G05RK.
PhylomeDBiQ19905.

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.
BRENDAi1.1.1.22. 1045.
ReactomeiR-CEL-173599. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

EvolutionaryTraceiQ19905.
PROiQ19905.

Gene expression databases

BgeeiWBGene00005022.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUGDH_CAEEL
AccessioniPrimary (citable) accession number: Q19905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.