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Q19905

- UGDH_CAEEL

UniProt

Q19905 - UGDH_CAEEL

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Protein

UDP-glucose 6-dehydrogenase

Gene

sqv-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NADBy similarity
Binding sitei46 – 461NADBy similarity
Binding sitei172 – 1721NADBy similarity
Active sitei283 – 2831NucleophileBy similarity
Binding sitei353 – 3531NADBy similarity
Binding sitei447 – 4471SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216NADBy similarity
Nucleotide bindingi94 – 985NADBy similarity
Nucleotide bindingi135 – 1362NADBy similarity
Nucleotide bindingi283 – 2864NADBy similarity

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. NAD binding Source: InterPro
  3. UDP-glucose 6-dehydrogenase activity Source: WormBase

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. glycosaminoglycan biosynthetic process Source: WormBase
  3. morphogenesis of an epithelium Source: WormBase
  4. oviposition Source: WormBase
  5. reproduction Source: WormBase
  6. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  7. vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.1.1.22. 1045.
ReactomeiREACT_257637. Formation of the active cofactor, UDP-glucuronate.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Alternative name(s):
Squashed vulva protein 4
Gene namesi
Name:sqv-4
ORF Names:F29F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF29F11.1; CE05767; WBGene00005022; sqv-4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481UDP-glucose 6-dehydrogenasePRO_0000074063Add
BLAST

Proteomic databases

PaxDbiQ19905.
PRIDEiQ19905.

Expressioni

Tissue specificityi

Expressed in the vulva and in oocytes.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-320696,EBI-320696

Protein-protein interaction databases

BioGridi44513. 6 interactions.
DIPiDIP-24290N.
IntActiQ19905. 17 interactions.
MINTiMINT-1063665.
STRINGi6239.F29F11.1.2.

Structurei

Secondary structure

1
481
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 155Combined sources
Helixi21 – 3111Combined sources
Beta strandi35 – 406Combined sources
Helixi44 – 507Combined sources
Beta strandi52 – 543Combined sources
Helixi62 – 698Combined sources
Turni71 – 733Combined sources
Beta strandi74 – 785Combined sources
Helixi80 – 867Combined sources
Beta strandi88 – 925Combined sources
Turni103 – 1075Combined sources
Helixi112 – 12413Combined sources
Beta strandi129 – 1335Combined sources
Helixi141 – 15212Combined sources
Beta strandi161 – 1655Combined sources
Helixi175 – 1806Combined sources
Beta strandi185 – 1895Combined sources
Helixi193 – 20715Combined sources
Helixi212 – 2143Combined sources
Beta strandi215 – 2195Combined sources
Helixi220 – 25132Combined sources
Helixi255 – 2639Combined sources
Turni266 – 2683Combined sources
Beta strandi270 – 2723Combined sources
Beta strandi281 – 2833Combined sources
Helixi284 – 29714Combined sources
Helixi301 – 32828Combined sources
Turni329 – 3313Combined sources
Beta strandi337 – 3415Combined sources
Beta strandi344 – 3463Combined sources
Helixi356 – 36611Combined sources
Beta strandi370 – 3745Combined sources
Beta strandi376 – 3783Combined sources
Helixi380 – 39011Combined sources
Helixi393 – 3997Combined sources
Beta strandi400 – 4056Combined sources
Helixi406 – 4105Combined sources
Beta strandi414 – 4185Combined sources
Helixi423 – 4253Combined sources
Helixi430 – 4367Combined sources
Beta strandi442 – 4487Combined sources
Helixi452 – 4587Combined sources
Beta strandi461 – 4644Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O3JX-ray1.88A/B/C1-481[»]
ProteinModelPortaliQ19905.
SMRiQ19905. Positions 3-471.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ19905.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1725Substrate bindingBy similarity
Regioni227 – 2348Substrate bindingBy similarity
Regioni267 – 28014Substrate bindingBy similarityAdd
BLAST
Regioni345 – 3462Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
InParanoidiQ19905.
KOiK00012.
OMAiVELNTWQ.
PhylomeDBiQ19905.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19905-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW
60 70 80 90 100
NSDKLPIYEP GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM
110 120 130 140 150
YGRGKGMAPD LKYVESVSRT IAQYAGGPKI VVEKSTVPVK AAESIGCILR
160 170 180 190 200
EAQKNNENLK FQVLSNPEFL AEGTAMKDLA NPDRVLIGGE SSPEGLQAVA
210 220 230 240 250
ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS INSISAVCEA
260 270 280 290 300
TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL
310 320 330 340 350
PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG
360 370 380 390 400
DTRESSAIHV IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI
410 420 430 440 450
TVESDPYAAA RGAHAIVVLT EWDEFVELNY SQIHNDMQHP AAIFDGRLIL
460 470 480
DQKALREIGF RTFAIGTSPD QAYNLFGTAG Y
Length:481
Mass (Da):52,755
Last modified:November 1, 1996 - v1
Checksum:i4E789DC5D6679531
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.
PIRiT21550.
RefSeqiNP_505730.1. NM_073329.7.
UniGeneiCel.19769.

Genome annotation databases

EnsemblMetazoaiF29F11.1; F29F11.1; WBGene00005022.
GeneIDi179484.
KEGGicel:CELE_F29F11.1.
UCSCiF29F11.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147932 mRNA. Translation: AAN39842.1 .
Z73974 Genomic DNA. Translation: CAA98269.1 .
PIRi T21550.
RefSeqi NP_505730.1. NM_073329.7.
UniGenei Cel.19769.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O3J X-ray 1.88 A/B/C 1-481 [» ]
ProteinModelPortali Q19905.
SMRi Q19905. Positions 3-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44513. 6 interactions.
DIPi DIP-24290N.
IntActi Q19905. 17 interactions.
MINTi MINT-1063665.
STRINGi 6239.F29F11.1.2.

Proteomic databases

PaxDbi Q19905.
PRIDEi Q19905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F29F11.1 ; F29F11.1 ; WBGene00005022 .
GeneIDi 179484.
KEGGi cel:CELE_F29F11.1.
UCSCi F29F11.1.1. c. elegans.

Organism-specific databases

CTDi 179484.
WormBasei F29F11.1 ; CE05767 ; WBGene00005022 ; sqv-4.

Phylogenomic databases

eggNOGi COG1004.
GeneTreei ENSGT00390000015355.
HOGENOMi HOG000153773.
InParanoidi Q19905.
KOi K00012.
OMAi VELNTWQ.
PhylomeDBi Q19905.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .
BRENDAi 1.1.1.22. 1045.
Reactomei REACT_257637. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

EvolutionaryTracei Q19905.
NextBioi 905594.
PROi Q19905.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated."
    Hwang H.Y., Horvitz H.R.
    Proc. Natl. Acad. Sci. U.S.A. 99:14224-14229(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Crystal structure of caenorhabditis elegans udp-glucose dehydrogenase."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

Entry informationi

Entry nameiUGDH_CAEEL
AccessioniPrimary (citable) accession number: Q19905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3