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Q19905

- UGDH_CAEEL

UniProt

Q19905 - UGDH_CAEEL

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Protein

UDP-glucose 6-dehydrogenase

Gene
sqv-4, F29F11.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NAD By similarity
Binding sitei46 – 461NAD By similarity
Binding sitei172 – 1721NAD By similarity
Active sitei283 – 2831Nucleophile By similarity
Binding sitei353 – 3531NAD By similarity
Binding sitei447 – 4471Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 216NAD By similarity
Nucleotide bindingi94 – 985NAD By similarity
Nucleotide bindingi135 – 1362NAD By similarity
Nucleotide bindingi283 – 2864NAD By similarity

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. NAD binding Source: InterPro
  3. UDP-glucose 6-dehydrogenase activity Source: WormBase

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. glycosaminoglycan biosynthetic process Source: WormBase
  3. morphogenesis of an epithelium Source: WormBase
  4. oviposition Source: WormBase
  5. reproduction Source: WormBase
  6. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  7. vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.1.1.22. 1045.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Alternative name(s):
Squashed vulva protein 4
Gene namesi
Name:sqv-4
ORF Names:F29F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF29F11.1; CE05767; WBGene00005022; sqv-4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481UDP-glucose 6-dehydrogenasePRO_0000074063Add
BLAST

Proteomic databases

PaxDbiQ19905.
PRIDEiQ19905.

Expressioni

Tissue specificityi

Expressed in the vulva and in oocytes.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-320696,EBI-320696

Protein-protein interaction databases

BioGridi44513. 6 interactions.
DIPiDIP-24290N.
IntActiQ19905. 17 interactions.
MINTiMINT-1063665.
STRINGi6239.F29F11.1.2.

Structurei

Secondary structure

1
481
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 155
Helixi21 – 3111
Beta strandi35 – 406
Helixi44 – 507
Beta strandi52 – 543
Helixi62 – 698
Turni71 – 733
Beta strandi74 – 785
Helixi80 – 867
Beta strandi88 – 925
Turni103 – 1075
Helixi112 – 12413
Beta strandi129 – 1335
Helixi141 – 15212
Beta strandi161 – 1655
Helixi175 – 1806
Beta strandi185 – 1895
Helixi193 – 20715
Helixi212 – 2143
Beta strandi215 – 2195
Helixi220 – 25132
Helixi255 – 2639
Turni266 – 2683
Beta strandi270 – 2723
Beta strandi281 – 2833
Helixi284 – 29714
Helixi301 – 32828
Turni329 – 3313
Beta strandi337 – 3415
Beta strandi344 – 3463
Helixi356 – 36611
Beta strandi370 – 3745
Beta strandi376 – 3783
Helixi380 – 39011
Helixi393 – 3997
Beta strandi400 – 4056
Helixi406 – 4105
Beta strandi414 – 4185
Helixi423 – 4253
Helixi430 – 4367
Beta strandi442 – 4487
Helixi452 – 4587
Beta strandi461 – 4644

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O3JX-ray1.88A/B/C1-481[»]
ProteinModelPortaliQ19905.
SMRiQ19905. Positions 3-471.

Miscellaneous databases

EvolutionaryTraceiQ19905.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1725Substrate binding By similarity
Regioni227 – 2348Substrate binding By similarity
Regioni267 – 28014Substrate binding By similarityAdd
BLAST
Regioni345 – 3462Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
InParanoidiQ19905.
KOiK00012.
OMAiVELNTWQ.
PhylomeDBiQ19905.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19905-1 [UniParc]FASTAAdd to Basket

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MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHITVTVV DMNTAKIAEW    50
NSDKLPIYEP GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM 100
YGRGKGMAPD LKYVESVSRT IAQYAGGPKI VVEKSTVPVK AAESIGCILR 150
EAQKNNENLK FQVLSNPEFL AEGTAMKDLA NPDRVLIGGE SSPEGLQAVA 200
ELVRIYENWV PRNRIITTNT WSSELSKLVA NAFLAQRISS INSISAVCEA 250
TGAEISEVAH AVGYDTRIGS KFLQASVGFG GSCFQKDVLS LVYLCESLNL 300
PQVADYWQGV ININNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG 350
DTRESSAIHV IKHLMEEHAK LSVYDPKVQK SQMLNDLASV TSAQDVERLI 400
TVESDPYAAA RGAHAIVVLT EWDEFVELNY SQIHNDMQHP AAIFDGRLIL 450
DQKALREIGF RTFAIGTSPD QAYNLFGTAG Y 481
Length:481
Mass (Da):52,755
Last modified:November 1, 1996 - v1
Checksum:i4E789DC5D6679531
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147932 mRNA. Translation: AAN39842.1.
Z73974 Genomic DNA. Translation: CAA98269.1.
PIRiT21550.
RefSeqiNP_505730.1. NM_073329.7.
UniGeneiCel.19769.

Genome annotation databases

EnsemblMetazoaiF29F11.1; F29F11.1; WBGene00005022.
GeneIDi179484.
KEGGicel:CELE_F29F11.1.
UCSCiF29F11.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147932 mRNA. Translation: AAN39842.1 .
Z73974 Genomic DNA. Translation: CAA98269.1 .
PIRi T21550.
RefSeqi NP_505730.1. NM_073329.7.
UniGenei Cel.19769.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O3J X-ray 1.88 A/B/C 1-481 [» ]
ProteinModelPortali Q19905.
SMRi Q19905. Positions 3-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44513. 6 interactions.
DIPi DIP-24290N.
IntActi Q19905. 17 interactions.
MINTi MINT-1063665.
STRINGi 6239.F29F11.1.2.

Proteomic databases

PaxDbi Q19905.
PRIDEi Q19905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F29F11.1 ; F29F11.1 ; WBGene00005022 .
GeneIDi 179484.
KEGGi cel:CELE_F29F11.1.
UCSCi F29F11.1.1. c. elegans.

Organism-specific databases

CTDi 179484.
WormBasei F29F11.1 ; CE05767 ; WBGene00005022 ; sqv-4.

Phylogenomic databases

eggNOGi COG1004.
GeneTreei ENSGT00390000015355.
HOGENOMi HOG000153773.
InParanoidi Q19905.
KOi K00012.
OMAi VELNTWQ.
PhylomeDBi Q19905.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .
BRENDAi 1.1.1.22. 1045.

Miscellaneous databases

EvolutionaryTracei Q19905.
NextBioi 905594.
PROi Q19905.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated."
    Hwang H.Y., Horvitz H.R.
    Proc. Natl. Acad. Sci. U.S.A. 99:14224-14229(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Crystal structure of caenorhabditis elegans udp-glucose dehydrogenase."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

Entry informationi

Entry nameiUGDH_CAEEL
AccessioniPrimary (citable) accession number: Q19905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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