Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Propionyl-CoA carboxylase alpha chain, mitochondrial

Gene

pcca-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.By similarity

Cofactori

biotinBy similarity

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Propionyl-CoA carboxylase alpha chain, mitochondrial (pcca-1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163ATPBy similarity1
Binding sitei247ATPBy similarity1
Binding sitei282ATPBy similarity1
Active sitei339By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-196780. Biotin transport and metabolism.
R-CEL-71032. Propionyl-CoA catabolism.
UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA carboxylase alpha chain, mitochondrial (EC:6.4.1.3)
Short name:
PCCase subunit alpha
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase subunit alpha
Gene namesi
Name:pcca-1
ORF Names:F27D9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF27D9.5; CE04451; WBGene00017864; pcca-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000234102? – 724Propionyl-CoA carboxylase alpha chain, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei690N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

EPDiQ19842.
PaxDbiQ19842.
PeptideAtlasiQ19842.
PRIDEiQ19842.

2D gel databases

World-2DPAGEi0011:Q19842.

Expressioni

Gene expression databases

BgeeiWBGene00017864.

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Protein-protein interaction databases

STRINGi6239.F27D9.5.2.

Structurei

3D structure databases

ProteinModelPortaliQ19842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 495Biotin carboxylationSequence analysisAdd BLAST448
Domaini167 – 364ATP-graspPROSITE-ProRule annotationAdd BLAST198
Domaini649 – 724Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0238. Eukaryota.
COG4770. LUCA.
GeneTreeiENSGT00550000074675.
HOGENOMiHOG000008989.
InParanoidiQ19842.
KOiK01965.
OMAiDYDPMLA.
OrthoDBiEOG091G06RG.
PhylomeDBiQ19842.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
SMARTiView protein in SMART
SM00878. Biotin_carb_C. 1 hit.
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q19842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAASSIRA VANRGLATAA VARPGVPLDE REGKEIYTTV GIDYNEPKFD
60 70 80 90 100
KILIANRGEI ACRVIKTARA MGIKTVAVHS DVDSNSLHVK MADEAVCVGE
110 120 130 140 150
APTAKSYLRA DRILQAVEDT GAQAVHPGYG FLSENTKFAA ELEKAGAKFI
160 170 180 190 200
GPNSKAILDM GDKIHSKKIA TAARVSMIPG YDGEIADEDM CVKVSRDIGY
210 220 230 240 250
PVMIKASAGG GGKGMRVAWN DKQAREGYRL SKQEAASSFG DDRMLVEKFI
260 270 280 290 300
DNPRHIEMQV LCDKHGNALW LNERECSIQR RNQKVIEEAP SSFVPPEMRR
310 320 330 340 350
KMGEQAVQLA KAVGYDSAGT VEFLVDSQRN FYFLEMNTRL QVEHPITECI
360 370 380 390 400
TGIDIVQQML RVSYGHPLPI TQEQVPLNGW AFESRVYAED PYKGFGLPSV
410 420 430 440 450
GRLSRYVEPK HVDGVRCDSG IREGSEISIY YDPLICKLVT HGDNREQALN
460 470 480 490 500
RMQEALDNYV IRGVTHNIPL LRDIVQEKRF RTGDITTKYL PEVYPEGFQG
510 520 530 540 550
TSLSPKEQDV VIAFASALNA RKLARANQFL NQNKQRSTHV ASFSKTYKFV
560 570 580 590 600
SSLPVKEGER PTEHAVEVEF VEGSANKAQV RIGGKTVTIS GDLNLSHPVN
610 620 630 640 650
SIEVDGEHIT TQIVGKRAGE ITVLYKGTPF KVKVLPEQAV KYLQYMKEKA
660 670 680 690 700
KVDLSTVVLS PMPGAIKNVN VKPGDMVSEG QELVVMEAMK MQNSLHAGKT
710 720
GRVKAVNVKV GATVDEGEVL VELE
Length:724
Mass (Da):79,762
Last modified:November 1, 1996 - v1
Checksum:iE09832FB65AABA45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080935 Genomic DNA. Translation: CCD67920.1.
PIRiT16187.
RefSeqiNP_509293.1. NM_076892.4.
UniGeneiCel.6797.

Genome annotation databases

EnsemblMetazoaiF27D9.5; F27D9.5; WBGene00017864.
GeneIDi181026.
KEGGicel:CELE_F27D9.5.
UCSCiF27D9.5. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPCCA_CAEEL
AccessioniPrimary (citable) accession number: Q19842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways