Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Propionyl-CoA carboxylase alpha chain, mitochondrial

Gene

pcca-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.By similarity

Cofactori

biotinBy similarity

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Propionyl-CoA carboxylase alpha chain, mitochondrial (pcca-1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei163ATPBy similarity1
Binding sitei247ATPBy similarity1
Binding sitei282ATPBy similarity1
Active sitei339By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-196780 Biotin transport and metabolism
R-CEL-71032 Propionyl-CoA catabolism
UniPathwayiUPA00945; UER00908

Names & Taxonomyi

Protein namesi
Recommended name:
Propionyl-CoA carboxylase alpha chain, mitochondrial (EC:6.4.1.3)
Short name:
PCCase subunit alpha
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase subunit alpha
Gene namesi
Name:pcca-1
ORF Names:F27D9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF27D9.5 ; CE04451 ; WBGene00017864 ; pcca-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000234102? – 724Propionyl-CoA carboxylase alpha chain, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei690N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

EPDiQ19842
PaxDbiQ19842
PeptideAtlasiQ19842
PRIDEiQ19842

2D gel databases

World-2DPAGEi0011:Q19842

Expressioni

Gene expression databases

BgeeiWBGene00017864

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits (By similarity). Interacts with sir-2.2 and sir-2.3 (PubMed:23438705).By similarity1 Publication

Protein-protein interaction databases

STRINGi6239.F27D9.5.2

Structurei

3D structure databases

ProteinModelPortaliQ19842
SMRiQ19842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 495Biotin carboxylationSequence analysisAdd BLAST448
Domaini167 – 364ATP-graspPROSITE-ProRule annotationAdd BLAST198
Domaini649 – 724Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0238 Eukaryota
COG4770 LUCA
GeneTreeiENSGT00550000074675
HOGENOMiHOG000008989
InParanoidiQ19842
KOiK01965
OMAiGGNMSIQ
OrthoDBiEOG091G06RG
PhylomeDBiQ19842

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q19842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAASSIRA VANRGLATAA VARPGVPLDE REGKEIYTTV GIDYNEPKFD
60 70 80 90 100
KILIANRGEI ACRVIKTARA MGIKTVAVHS DVDSNSLHVK MADEAVCVGE
110 120 130 140 150
APTAKSYLRA DRILQAVEDT GAQAVHPGYG FLSENTKFAA ELEKAGAKFI
160 170 180 190 200
GPNSKAILDM GDKIHSKKIA TAARVSMIPG YDGEIADEDM CVKVSRDIGY
210 220 230 240 250
PVMIKASAGG GGKGMRVAWN DKQAREGYRL SKQEAASSFG DDRMLVEKFI
260 270 280 290 300
DNPRHIEMQV LCDKHGNALW LNERECSIQR RNQKVIEEAP SSFVPPEMRR
310 320 330 340 350
KMGEQAVQLA KAVGYDSAGT VEFLVDSQRN FYFLEMNTRL QVEHPITECI
360 370 380 390 400
TGIDIVQQML RVSYGHPLPI TQEQVPLNGW AFESRVYAED PYKGFGLPSV
410 420 430 440 450
GRLSRYVEPK HVDGVRCDSG IREGSEISIY YDPLICKLVT HGDNREQALN
460 470 480 490 500
RMQEALDNYV IRGVTHNIPL LRDIVQEKRF RTGDITTKYL PEVYPEGFQG
510 520 530 540 550
TSLSPKEQDV VIAFASALNA RKLARANQFL NQNKQRSTHV ASFSKTYKFV
560 570 580 590 600
SSLPVKEGER PTEHAVEVEF VEGSANKAQV RIGGKTVTIS GDLNLSHPVN
610 620 630 640 650
SIEVDGEHIT TQIVGKRAGE ITVLYKGTPF KVKVLPEQAV KYLQYMKEKA
660 670 680 690 700
KVDLSTVVLS PMPGAIKNVN VKPGDMVSEG QELVVMEAMK MQNSLHAGKT
710 720
GRVKAVNVKV GATVDEGEVL VELE
Length:724
Mass (Da):79,762
Last modified:November 1, 1996 - v1
Checksum:iE09832FB65AABA45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080935 Genomic DNA Translation: CCD67920.1
PIRiT16187
RefSeqiNP_509293.1, NM_076892.4
UniGeneiCel.6797

Genome annotation databases

EnsemblMetazoaiF27D9.5.1; F27D9.5.1; WBGene00017864
F27D9.5.2; F27D9.5.2; WBGene00017864
GeneIDi181026
KEGGicel:CELE_F27D9.5
UCSCiF27D9.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPCCA_CAEEL
AccessioniPrimary (citable) accession number: Q19842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health