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Protein
Submitted name:

NEPrilysin metallopeptidase family

Gene

nep-12

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM13.A26.

Names & Taxonomyi

Protein namesi
Submitted name:
NEPrilysin metallopeptidase familyImported
Gene namesi
Name:nep-12Imported
ORF Names:CELE_F26G1.6Imported, F26G1.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF26G1.6; CE37363; WBGene00017842; nep-12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 52HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ19831.

Expressioni

Gene expression databases

BgeeiWBGene00017842.

Interactioni

Protein-protein interaction databases

STRINGi6239.F26G1.6.

Structurei

3D structure databases

ProteinModelPortaliQ19831.
SMRiQ19831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 504Peptidase_M13_NInterPro annotationAdd BLAST392
Domaini530 – 733Peptidase_M13InterPro annotationAdd BLAST204

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000021868.
InParanoidiQ19831.
KOiK01389.
OMAiAPAFSNY.
OrthoDBiEOG091G021W.
PhylomeDBiQ19831.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 2 hits.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

Q19831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKSKTVMI DYSITKILER NKKNARLAAV FAALFILTLL ISISFITIVA
60 70 80 90 100
ILSDGFSTLI SGSELCSNTE GDAYEVKNSN HVNYGSDNST CLTPECIRLA
110 120 130 140 150
ASYLNNMNRD ANPCEDFYEF ACGKYATRKV IAEHEKKVTV LSEMKKEMDR
160 170 180 190 200
HLKDILEKTS RENTTRSMKL AQIYFDSCMD EFSQDDLGVQ PLMSMISNLG
210 220 230 240 250
GWPLLTNARF DSIDFQWEVL AGHLALYGVD GIFRVFVHSS FDDSDKNVLM
260 270 280 290 300
FSPPKLFLEK KKFYREVPSS NVYLQYYRQY ILSLLSLLGV DMEDETGVIE
310 320 330 340 350
YQVDDIIDFE RRIANLTRIE LSRNHSSINN MITFGEFKRK YDKINWDAFF
360 370 380 390 400
NEEMRGNLGR MPDSLVINVV DVNYFDNLYS LIKSKPLSSI NNFLMWCLVS
410 420 430 440 450
NYDMYLPAKY RKPMLDFRQK MYGVSSDDPL WEVCVGEVRE NLAMPLSTEY
460 470 480 490 500
AQKFFTKKDK LVAEDMIRDL KKAMEQTLLN ADWIDESTRE AALMKLDAMG
510 520 530 540 550
HKIGDALSKL HRTPSLIDWA SPIIAVDAFH YFTGNEIIFP AGILQFPMFV
560 570 580 590 600
PDAPAFSNYG AIGMGIGHEI THGYDDLGAQ YDDKGNLRGW WHTETMTTFQ
610 620 630 640 650
KKKQCFVAQY GSKIEPQTGR KVDGKMTIGE NIADNGGLRV AFQAYQLRSD
660 670 680 690 700
REKETRRLPG LTDFSPNQLF FLAYANTWCE ALKPSAIDHI MDTDVHSLGM
710 720 730
FRVNVPLQNL PAFSKEFDCP IGSPMNPFEK CRIW
Length:734
Mass (Da):83,960
Last modified:October 11, 2004 - v3
Checksum:i6D0A2CCF57623179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD65849.1.
PIRiT16182.
RefSeqiNP_494857.2. NM_062456.3.
UniGeneiCel.15305.

Genome annotation databases

EnsemblMetazoaiF26G1.6; F26G1.6; WBGene00017842.
GeneIDi173824.
KEGGicel:CELE_F26G1.6.
UCSCiF26G1.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD65849.1.
PIRiT16182.
RefSeqiNP_494857.2. NM_062456.3.
UniGeneiCel.15305.

3D structure databases

ProteinModelPortaliQ19831.
SMRiQ19831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F26G1.6.

Protein family/group databases

MEROPSiM13.A26.

Proteomic databases

PaxDbiQ19831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26G1.6; F26G1.6; WBGene00017842.
GeneIDi173824.
KEGGicel:CELE_F26G1.6.
UCSCiF26G1.6. c. elegans.

Organism-specific databases

CTDi173824.
WormBaseiF26G1.6; CE37363; WBGene00017842; nep-12.

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000021868.
InParanoidiQ19831.
KOiK01389.
OMAiAPAFSNY.
OrthoDBiEOG091G021W.
PhylomeDBiQ19831.

Gene expression databases

BgeeiWBGene00017842.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 2 hits.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Entry informationi

Entry nameiQ19831_CAEEL
AccessioniPrimary (citable) accession number: Q19831
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.