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Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

rrt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: GO_Central
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.19. 1045.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rrt-1
ORF Names:F26F4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF26F4.10a; CE29495; WBGene00004679; rars-1.

Subcellular locationi

  1. Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Probable arginine--tRNA ligase, cytoplasmicPRO_0000151661Add
BLAST

Proteomic databases

PaxDbiQ19825.
PRIDEiQ19825.

Expressioni

Gene expression databases

ExpressionAtlasiQ19825. baseline.

Interactioni

Protein-protein interaction databases

BioGridi40893. 2 interactions.
MINTiMINT-1083181.
STRINGi6239.F26F4.10a.1.

Structurei

3D structure databases

ProteinModelPortaliQ19825.
SMRiQ19825. Positions 6-713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi252 – 26312"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247212.
InParanoidiQ19825.
KOiK01887.
OMAiTAMFLLY.
OrthoDBiEOG764725.
PhylomeDBiQ19825.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA
60 70 80 90 100
KKLNDKLKYR KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA
110 120 130 140 150
KKDGKTGGAP PKQAKKVDYV TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV
160 170 180 190 200
PLLLAETPNP QFGDYQCNSA MPIAAKLKAN KINKRPGDVA KEIQAKLPTK
210 220 230 240 250
IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK LTRKRVLVDF
260 270 280 290 300
SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML
310 320 330 340 350
IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ
360 370 380 390 400
SHDGDIVKAW NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW
410 420 430 440 450
VKTNKPDMLR EEDGRQIMFP TGCDIPLTVV KSDGGFTYDT SDLAALKYRM
460 470 480 490 500
LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF GWYDESIQRV EHVAFGLVLG
510 520 530 540 550
DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM SEEQLVAARD
560 570 580 590 600
AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE
610 620 630 640 650
KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH
660 670 680 690 700
QMCDYVYQLA TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST
710
CFKILGLREV NKM
Length:713
Mass (Da):80,896
Last modified:June 6, 2002 - v2
Checksum:iAC3268576C8D5BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080682 Genomic DNA. Translation: CCD65757.1.
PIRiT16176.
RefSeqiNP_001022551.1. NM_001027380.5.
UniGeneiCel.17117.

Genome annotation databases

EnsemblMetazoaiF26F4.10a.1; F26F4.10a.1; WBGene00004679.
F26F4.10a.2; F26F4.10a.2; WBGene00004679.
GeneIDi175659.
KEGGicel:CELE_F26F4.10.
UCSCiF26F4.10b.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080682 Genomic DNA. Translation: CCD65757.1.
PIRiT16176.
RefSeqiNP_001022551.1. NM_001027380.5.
UniGeneiCel.17117.

3D structure databases

ProteinModelPortaliQ19825.
SMRiQ19825. Positions 6-713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40893. 2 interactions.
MINTiMINT-1083181.
STRINGi6239.F26F4.10a.1.

Proteomic databases

PaxDbiQ19825.
PRIDEiQ19825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26F4.10a.1; F26F4.10a.1; WBGene00004679.
F26F4.10a.2; F26F4.10a.2; WBGene00004679.
GeneIDi175659.
KEGGicel:CELE_F26F4.10.
UCSCiF26F4.10b.1. c. elegans.

Organism-specific databases

CTDi175659.
WormBaseiF26F4.10a; CE29495; WBGene00004679; rars-1.

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247212.
InParanoidiQ19825.
KOiK01887.
OMAiTAMFLLY.
OrthoDBiEOG764725.
PhylomeDBiQ19825.

Enzyme and pathway databases

BRENDAi6.1.1.19. 1045.

Miscellaneous databases

NextBioi889098.
PROiQ19825.

Gene expression databases

ExpressionAtlasiQ19825. baseline.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSYRC_CAEEL
AccessioniPrimary (citable) accession number: Q19825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 1, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.