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Q19825 (SYRC_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable arginine--tRNA ligase, cytoplasmic

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:rrt-1
ORF Names:F26F4.10
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length713 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis By similarity. HAMAP-Rule MF_00123

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 713713Probable arginine--tRNA ligase, cytoplasmic HAMAP-Rule MF_00123
PRO_0000151661

Regions

Motif252 – 26312"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q19825 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: AC3268576C8D5BC4

FASTA71380,896
        10         20         30         40         50         60 
MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA KKLNDKLKYR 

        70         80         90        100        110        120 
KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA KKDGKTGGAP PKQAKKVDYV 

       130        140        150        160        170        180 
TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV PLLLAETPNP QFGDYQCNSA MPIAAKLKAN 

       190        200        210        220        230        240 
KINKRPGDVA KEIQAKLPTK IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK 

       250        260        270        280        290        300 
LTRKRVLVDF SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML 

       310        320        330        340        350        360 
IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ SHDGDIVKAW 

       370        380        390        400        410        420 
NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW VKTNKPDMLR EEDGRQIMFP 

       430        440        450        460        470        480 
TGCDIPLTVV KSDGGFTYDT SDLAALKYRM LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF 

       490        500        510        520        530        540 
GWYDESIQRV EHVAFGLVLG DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM 

       550        560        570        580        590        600 
SEEQLVAARD AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE 

       610        620        630        640        650        660 
KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH QMCDYVYQLA 

       670        680        690        700        710 
TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST CFKILGLREV NKM 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080682 Genomic DNA. Translation: CCD65757.1.
PIRT16176.
RefSeqNP_001022551.1. NM_001027380.5.
UniGeneCel.17117.

3D structure databases

ProteinModelPortalQ19825.
SMRQ19825. Positions 125-713.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40893. 2 interactions.
MINTMINT-1083181.
STRING6239.F26F4.10a.1.

Proteomic databases

PaxDbQ19825.
PRIDEQ19825.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF26F4.10a.1; F26F4.10a.1; F26F4.10.
F26F4.10a.2; F26F4.10a.2; F26F4.10.
GeneID175659.
KEGGcel:CELE_F26F4.10.
UCSCF26F4.10b.1. c. elegans.

Organism-specific databases

CTD175659.
WormBaseF26F4.10a; CE29495; WBGene00004679; rars-1.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
InParanoidQ19825.
KOK01887.
OMAPDITKAW.
OrthoDBEOG764725.
PhylomeDBQ19825.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889098.
PROQ19825.

Entry information

Entry nameSYRC_CAEEL
AccessionPrimary (citable) accession number: Q19825
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries