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Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

rrt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263L-arginineBy similarity1
Binding sitei438L-arginineBy similarity1
Binding sitei442L-arginineBy similarity1
Binding sitei466L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • arginyl-tRNA aminoacylation Source: GO_Central
  • determination of adult lifespan Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • translation Source: UniProtKB

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.19. 1045.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rrt-1
ORF Names:F26F4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF26F4.10a; CE29495; WBGene00004679; rars-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516611 – 713Probable arginine--tRNA ligase, cytoplasmicAdd BLAST713

Proteomic databases

EPDiQ19825.
PaxDbiQ19825.
PeptideAtlasiQ19825.
PRIDEiQ19825.

PTM databases

iPTMnetiQ19825.

Expressioni

Gene expression databases

BgeeiWBGene00004679.
ExpressionAtlasiQ19825. baseline.

Interactioni

Protein-protein interaction databases

BioGridi40893. 2 interactors.
IntActiQ19825. 1 interactor.
MINTiMINT-1083181.
STRINGi6239.F26F4.10a.2.

Structurei

3D structure databases

ProteinModelPortaliQ19825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 254L-arginine bindingBy similarity3
Regioni583 – 597Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 263"HIGH" regionAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247212.
InParanoidiQ19825.
KOiK01887.
OMAiNKPLHLG.
OrthoDBiEOG091G03A6.
PhylomeDBiQ19825.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA
60 70 80 90 100
KKLNDKLKYR KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA
110 120 130 140 150
KKDGKTGGAP PKQAKKVDYV TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV
160 170 180 190 200
PLLLAETPNP QFGDYQCNSA MPIAAKLKAN KINKRPGDVA KEIQAKLPTK
210 220 230 240 250
IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK LTRKRVLVDF
260 270 280 290 300
SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML
310 320 330 340 350
IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ
360 370 380 390 400
SHDGDIVKAW NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW
410 420 430 440 450
VKTNKPDMLR EEDGRQIMFP TGCDIPLTVV KSDGGFTYDT SDLAALKYRM
460 470 480 490 500
LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF GWYDESIQRV EHVAFGLVLG
510 520 530 540 550
DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM SEEQLVAARD
560 570 580 590 600
AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE
610 620 630 640 650
KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH
660 670 680 690 700
QMCDYVYQLA TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST
710
CFKILGLREV NKM
Length:713
Mass (Da):80,896
Last modified:June 6, 2002 - v2
Checksum:iAC3268576C8D5BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080682 Genomic DNA. Translation: CCD65757.1.
PIRiT16176.
RefSeqiNP_001022551.1. NM_001027380.5.
UniGeneiCel.17117.

Genome annotation databases

EnsemblMetazoaiF26F4.10a.1; F26F4.10a.1; WBGene00004679.
F26F4.10a.2; F26F4.10a.2; WBGene00004679.
GeneIDi175659.
KEGGicel:CELE_F26F4.10.
UCSCiF26F4.10b.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiSYRC_CAEEL
AccessioniPrimary (citable) accession number: Q19825
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: September 27, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families