Reviewed, UniProtKB/Swiss-Prot Q19825 (SYRC_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable arginyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	rrt-1
ORF Names:	F26F4.10

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	713 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase positive regulation of embryonic development Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 713	713	Probable arginyl-tRNA synthetase, cytoplasmic		PRO_0000151661
Regions
	Motif	252 – 263	12	"HIGH" region

Sequences

	Sequence		Length	Mass (Da)
	Q19825-1 [UniParc]. Last modified June 6, 2002. Version 2. Checksum: AC3268576C8D5BC4	FASTA	713	80,896
	10 20 30 40 50 60 MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA KKLNDKLKYR 70 80 90 100 110 120 KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA KKDGKTGGAP PKQAKKVDYV 130 140 150 160 170 180 TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV PLLLAETPNP QFGDYQCNSA MPIAAKLKAN 190 200 210 220 230 240 KINKRPGDVA KEIQAKLPTK IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK 250 260 270 280 290 300 LTRKRVLVDF SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML 310 320 330 340 350 360 IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ SHDGDIVKAW 370 380 390 400 410 420 NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW VKTNKPDMLR EEDGRQIMFP 430 440 450 460 470 480 TGCDIPLTVV KSDGGFTYDT SDLAALKYRM LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF 490 500 510 520 530 540 GWYDESIQRV EHVAFGLVLG DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM 550 560 570 580 590 600 SEEQLVAARD AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE 610 620 630 640 650 660 KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH QMCDYVYQLA 670 680 690 700 710 TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST CFKILGLREV NKM

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U12964 Genomic DNA. Translation: AAA91224.2.
PIR	T16176.
RefSeq	NP_001022551.1.
UniGene	Cel.17117
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q19825. 1 interaction.
STRING	Q19825.
Proteomic databases
PRIDE	Q19825.
Genome annotation databases
Ensembl	F26F4.10a.1; F26F4.10a.1; F26F4.10; Caenorhabditis elegans. [Genome view] F26F4.10a.2; F26F4.10a.2; F26F4.10; Caenorhabditis elegans. [Genome view]
GeneID	175659.
KEGG	cel:F26F4.10.
NMPDR	fig|6239.3.peg.9601.
UCSC	F26F4.10b.1. c. elegans.
Organism-specific databases
CTD	175659.
WormBase	WBGene00004679. rrt-1.
WormPep	F26F4.10. CE29495. [WorfDB]
Phylogenomic databases
OMA	HMGFGTM.
Enzyme and pathway databases
BRENDA	6.1.1.19. 672.
Gene expression databases
ArrayExpress	Q19825.
Family and domain databases
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	889098.

Entry information

Entry name

SYRC_CAEEL

Accession

Primary (citable) accession number: Q19825

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 6, 2002
Last modified:	November 3, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project