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Q19825

- SYRC_CAEEL

UniProt

Q19825 - SYRC_CAEEL

Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

rrt-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:rrt-1
    ORF Names:F26F4.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF26F4.10a; CE29495; WBGene00004679; rars-1.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 713713Probable arginine--tRNA ligase, cytoplasmicPRO_0000151661Add
    BLAST

    Proteomic databases

    PaxDbiQ19825.
    PRIDEiQ19825.

    Interactioni

    Protein-protein interaction databases

    BioGridi40893. 2 interactions.
    MINTiMINT-1083181.
    STRINGi6239.F26F4.10a.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ19825.
    SMRiQ19825. Positions 128-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi252 – 26312"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    GeneTreeiENSGT00530000063407.
    HOGENOMiHOG000247212.
    InParanoidiQ19825.
    KOiK01887.
    OMAiKCFDILG.
    OrthoDBiEOG764725.
    PhylomeDBiQ19825.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q19825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA    50
    KKLNDKLKYR KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA 100
    KKDGKTGGAP PKQAKKVDYV TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV 150
    PLLLAETPNP QFGDYQCNSA MPIAAKLKAN KINKRPGDVA KEIQAKLPTK 200
    IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK LTRKRVLVDF 250
    SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML 300
    IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ 350
    SHDGDIVKAW NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW 400
    VKTNKPDMLR EEDGRQIMFP TGCDIPLTVV KSDGGFTYDT SDLAALKYRM 450
    LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF GWYDESIQRV EHVAFGLVLG 500
    DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM SEEQLVAARD 550
    AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE 600
    KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH 650
    QMCDYVYQLA TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST 700
    CFKILGLREV NKM 713
    Length:713
    Mass (Da):80,896
    Last modified:June 6, 2002 - v2
    Checksum:iAC3268576C8D5BC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080682 Genomic DNA. Translation: CCD65757.1.
    PIRiT16176.
    RefSeqiNP_001022551.1. NM_001027380.5.
    UniGeneiCel.17117.

    Genome annotation databases

    EnsemblMetazoaiF26F4.10a.1; F26F4.10a.1; WBGene00004679.
    F26F4.10a.2; F26F4.10a.2; WBGene00004679.
    GeneIDi175659.
    KEGGicel:CELE_F26F4.10.
    UCSCiF26F4.10b.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080682 Genomic DNA. Translation: CCD65757.1 .
    PIRi T16176.
    RefSeqi NP_001022551.1. NM_001027380.5.
    UniGenei Cel.17117.

    3D structure databases

    ProteinModelPortali Q19825.
    SMRi Q19825. Positions 128-712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40893. 2 interactions.
    MINTi MINT-1083181.
    STRINGi 6239.F26F4.10a.1.

    Proteomic databases

    PaxDbi Q19825.
    PRIDEi Q19825.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F26F4.10a.1 ; F26F4.10a.1 ; WBGene00004679 .
    F26F4.10a.2 ; F26F4.10a.2 ; WBGene00004679 .
    GeneIDi 175659.
    KEGGi cel:CELE_F26F4.10.
    UCSCi F26F4.10b.1. c. elegans.

    Organism-specific databases

    CTDi 175659.
    WormBasei F26F4.10a ; CE29495 ; WBGene00004679 ; rars-1.

    Phylogenomic databases

    eggNOGi COG0018.
    GeneTreei ENSGT00530000063407.
    HOGENOMi HOG000247212.
    InParanoidi Q19825.
    KOi K01887.
    OMAi KCFDILG.
    OrthoDBi EOG764725.
    PhylomeDBi Q19825.

    Miscellaneous databases

    NextBioi 889098.
    PROi Q19825.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSYRC_CAEEL
    AccessioniPrimary (citable) accession number: Q19825
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3