Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

rars-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263L-arginineBy similarity1
Binding sitei438L-arginineBy similarity1
Binding sitei442L-arginineBy similarity1
Binding sitei466L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • arginyl-tRNA aminoacylation Source: GO_Central
  • determination of adult lifespan Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • translation Source: UniProtKB

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.19 1045

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars-1Imported
Synonyms:rrt-1Imported
ORF Names:F26F4.10Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF26F4.10a ; CE29495 ; WBGene00004679 ; rars-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516611 – 713Probable arginine--tRNA ligase, cytoplasmicAdd BLAST713

Proteomic databases

EPDiQ19825
PaxDbiQ19825
PeptideAtlasiQ19825
PRIDEiQ19825

PTM databases

iPTMnetiQ19825

Expressioni

Gene expression databases

BgeeiWBGene00004679
ExpressionAtlasiQ19825 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi40893, 2 interactors
STRINGi6239.F26F4.10a.2

Structurei

3D structure databases

ProteinModelPortaliQ19825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 254L-arginine bindingBy similarity3
Regioni583 – 597Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 263"HIGH" regionAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195 Eukaryota
COG0018 LUCA
GeneTreeiENSGT00530000063407
HOGENOMiHOG000247212
InParanoidiQ19825
KOiK01887
OMAiNKPLHLG
OrthoDBiEOG091G03A6
PhylomeDBiQ19825

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q19825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANKELQQG YSDYSAASDQ AALLNRLITA MQKGELTDEL LEHIPELGDA
60 70 80 90 100
KKLNDKLKYR KSILEKSIAE QAAKNKKNGV KATSTSSPSS STSAPAEKKA
110 120 130 140 150
KKDGKTGGAP PKQAKKVDYV TVEDYGSSIF GRLQSLFKKA IEDAFPGLDV
160 170 180 190 200
PLLLAETPNP QFGDYQCNSA MPIAAKLKAN KINKRPGDVA KEIQAKLPTK
210 220 230 240 250
IDFVEKIDVM PAGFINIFLN TDYLRRQISL LASEGVKLPK LTRKRVLVDF
260 270 280 290 300
SSPNIAKEMH VGHLRSTIIG DSICRLFEAV GFDVLRVNHI GDWGTQFGML
310 320 330 340 350
IAHLYDRFPD FLKKLPDISD LQAFYKESKK RFDEDEQFKK RAYEYVVKLQ
360 370 380 390 400
SHDGDIVKAW NTICDVSKKY NQIVYNYLDI KIKDVGESFY QDKMIELVKW
410 420 430 440 450
VKTNKPDMLR EEDGRQIMFP TGCDIPLTVV KSDGGFTYDT SDLAALKYRM
460 470 480 490 500
LEEKCDWNIY VVDSGQSLHL ETVYAAGRDF GWYDESIQRV EHVAFGLVLG
510 520 530 540 550
DDKKKFKTRS GETVRLLDLL SEGVKRATEK LIEKGRETAM SEEQLVAARD
560 570 580 590 600
AVAFGCVKYA DLSHTRTQDY VFSFDRMLED RGNTAVYLLY AYTRIQSIFE
610 620 630 640 650
KDEVKNVDLV KYIASTPTLP LDHPGEFKLA KQLLKLSDCV LLVLDSLMLH
660 670 680 690 700
QMCDYVYQLA TLFHDFYNEC YVIENKEGEK PFVHMHRLAL CDVTRKVMST
710
CFKILGLREV NKM
Length:713
Mass (Da):80,896
Last modified:June 6, 2002 - v2
Checksum:iAC3268576C8D5BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080682 Genomic DNA Translation: CCD65757.1
PIRiT16176
RefSeqiNP_001022551.1, NM_001027380.5
UniGeneiCel.17117

Genome annotation databases

EnsemblMetazoaiF26F4.10a.1; F26F4.10a.1; WBGene00004679
F26F4.10a.2; F26F4.10a.2; WBGene00004679
GeneIDi175659
KEGGicel:CELE_F26F4.10
UCSCiF26F4.10b.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSYRC_CAEEL
AccessioniPrimary (citable) accession number: Q19825
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health