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Q197B2

- RIR2_IIV3

UniProt

Q197B2 - RIR2_IIV3

Protein

Probable ribonucleoside-diphosphate reductase small subunit 048L

Gene

IIV3-048L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi110 – 1101Iron 1By similarity
    Metal bindingi140 – 1401Iron 1By similarity
    Metal bindingi140 – 1401Iron 2By similarity
    Metal bindingi143 – 1431Iron 1By similarity
    Active sitei147 – 1471By similarity
    Metal bindingi217 – 2171Iron 2By similarity
    Metal bindingi251 – 2511Iron 2By similarity
    Metal bindingi254 – 2541Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ribonucleoside-diphosphate reductase small subunit 048L (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    ORF Names:IIV3-048L
    OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
    Taxonomic identifieri345201 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
    Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
    Culex territans [TaxID: 42431]
    Culiseta annulata [TaxID: 332058]
    Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
    Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
    Psorophora ferox [TaxID: 7183]
    ProteomesiUP000001358: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Probable ribonucleoside-diphosphate reductase small subunit 048LPRO_0000376909Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q197B2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYEHLWLTA YGCLAVVGAV VVYCAIKQSL VTNWWFYGSI YPQVKLMADR    50
    TTFKPFEYPG CYDKWDTHEH AHWSFKELNM QDDVHDWHNR LSEAEKTFLV 100
    QILRFFTQGD VDVAVGYVQY LQLFQQPEVR MMLFSFGARE AMHIASYSHL 150
    ISTLNLPDVT YQEFLKYKAM KDKHEFVFNS RFKSTTVGRF FNYLLFGYDT 200
    HLEEIAVKIA LFSAFIEGVQ LFSSFIMLLN FTRHGLMKKM GQIIQWSIAD 250
    ETHHTNSMME LFSTLVVENK SHIRLGVLEA RVRDTARKIV QLEDGFIDLA 300
    FSMGEMRQLT ADDVKSYIRY ITNRRLQTMG YLPLYSVVEN PLPWVEDLLN 350
    APSHTNFFEN KPTEYAKASL TGDWPW 376
    Length:376
    Mass (Da):44,070
    Last modified:July 11, 2006 - v1
    Checksum:i8D3716EF3DA19D30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ643392 Genomic DNA. Translation: ABF82078.1.
    RefSeqiYP_654620.1. NC_008187.1.

    Genome annotation databases

    GeneIDi4156298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ643392 Genomic DNA. Translation: ABF82078.1 .
    RefSeqi YP_654620.1. NC_008187.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4156298.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
      Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
      J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR2_IIV3
    AccessioniPrimary (citable) accession number: Q197B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3