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Protein

Probable ribonucleoside-diphosphate reductase small subunit 048L

Gene

IIV3-048L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110Iron 1By similarity1
Metal bindingi140Iron 1By similarity1
Metal bindingi140Iron 2By similarity1
Metal bindingi143Iron 1By similarity1
Active sitei147By similarity1
Metal bindingi217Iron 2By similarity1
Metal bindingi251Iron 2By similarity1
Metal bindingi254Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonucleoside-diphosphate reductase small subunit 048L (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:IIV3-048L
OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Taxonomic identifieri345201 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeBetairidovirinaeChloriridovirus
Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
Proteomesi
  • UP000001358 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003769091 – 376Probable ribonucleoside-diphosphate reductase small subunit 048LAdd BLAST376

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000AL

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.201 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
PIRSFiPIRSF000355 NrdB, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

Q197B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYEHLWLTA YGCLAVVGAV VVYCAIKQSL VTNWWFYGSI YPQVKLMADR
60 70 80 90 100
TTFKPFEYPG CYDKWDTHEH AHWSFKELNM QDDVHDWHNR LSEAEKTFLV
110 120 130 140 150
QILRFFTQGD VDVAVGYVQY LQLFQQPEVR MMLFSFGARE AMHIASYSHL
160 170 180 190 200
ISTLNLPDVT YQEFLKYKAM KDKHEFVFNS RFKSTTVGRF FNYLLFGYDT
210 220 230 240 250
HLEEIAVKIA LFSAFIEGVQ LFSSFIMLLN FTRHGLMKKM GQIIQWSIAD
260 270 280 290 300
ETHHTNSMME LFSTLVVENK SHIRLGVLEA RVRDTARKIV QLEDGFIDLA
310 320 330 340 350
FSMGEMRQLT ADDVKSYIRY ITNRRLQTMG YLPLYSVVEN PLPWVEDLLN
360 370
APSHTNFFEN KPTEYAKASL TGDWPW
Length:376
Mass (Da):44,070
Last modified:July 11, 2006 - v1
Checksum:i8D3716EF3DA19D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA Translation: ABF82078.1
RefSeqiYP_654620.1, NC_008187.1

Genome annotation databases

GeneIDi4156298
KEGGivg:4156298

Similar proteinsi

Entry informationi

Entry nameiRIR2_IIV3
AccessioniPrimary (citable) accession number: Q197B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome