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Q197B2

- RIR2_IIV3

UniProt

Q197B2 - RIR2_IIV3

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Protein

Probable ribonucleoside-diphosphate reductase small subunit 048L

Gene
IIV3-048L
Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Iron 1 By similarity
Metal bindingi140 – 1401Iron 1 By similarity
Metal bindingi140 – 1401Iron 2 By similarity
Metal bindingi143 – 1431Iron 1 By similarity
Active sitei147 – 1471 By similarity
Metal bindingi217 – 2171Iron 2 By similarity
Metal bindingi251 – 2511Iron 2 By similarity
Metal bindingi254 – 2541Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonucleoside-diphosphate reductase small subunit 048L (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:IIV3-048L
OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Taxonomic identifieri345201 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
ProteomesiUP000001358: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Probable ribonucleoside-diphosphate reductase small subunit 048LPRO_0000376909Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q197B2-1 [UniParc]FASTAAdd to Basket

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MEYEHLWLTA YGCLAVVGAV VVYCAIKQSL VTNWWFYGSI YPQVKLMADR    50
TTFKPFEYPG CYDKWDTHEH AHWSFKELNM QDDVHDWHNR LSEAEKTFLV 100
QILRFFTQGD VDVAVGYVQY LQLFQQPEVR MMLFSFGARE AMHIASYSHL 150
ISTLNLPDVT YQEFLKYKAM KDKHEFVFNS RFKSTTVGRF FNYLLFGYDT 200
HLEEIAVKIA LFSAFIEGVQ LFSSFIMLLN FTRHGLMKKM GQIIQWSIAD 250
ETHHTNSMME LFSTLVVENK SHIRLGVLEA RVRDTARKIV QLEDGFIDLA 300
FSMGEMRQLT ADDVKSYIRY ITNRRLQTMG YLPLYSVVEN PLPWVEDLLN 350
APSHTNFFEN KPTEYAKASL TGDWPW 376
Length:376
Mass (Da):44,070
Last modified:July 11, 2006 - v1
Checksum:i8D3716EF3DA19D30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ643392 Genomic DNA. Translation: ABF82078.1.
RefSeqiYP_654620.1. NC_008187.1.

Genome annotation databases

GeneIDi4156298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ643392 Genomic DNA. Translation: ABF82078.1 .
RefSeqi YP_654620.1. NC_008187.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4156298.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
    Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
    J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_IIV3
AccessioniPrimary (citable) accession number: Q197B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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