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Q197B2 (RIR2_IIV3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribonucleoside-diphosphate reductase small subunit 048L

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
ORF Names:IIV3-048L
OrganismInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) [Reference proteome]
Taxonomic identifier345201 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
Virus hostAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Probable ribonucleoside-diphosphate reductase small subunit 048L
PRO_0000376909

Sites

Active site1471 By similarity
Metal binding1101Iron 1 By similarity
Metal binding1401Iron 1 By similarity
Metal binding1401Iron 2 By similarity
Metal binding1431Iron 1 By similarity
Metal binding2171Iron 2 By similarity
Metal binding2511Iron 2 By similarity
Metal binding2541Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q197B2 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 8D3716EF3DA19D30

FASTA37644,070
        10         20         30         40         50         60 
MEYEHLWLTA YGCLAVVGAV VVYCAIKQSL VTNWWFYGSI YPQVKLMADR TTFKPFEYPG 

        70         80         90        100        110        120 
CYDKWDTHEH AHWSFKELNM QDDVHDWHNR LSEAEKTFLV QILRFFTQGD VDVAVGYVQY 

       130        140        150        160        170        180 
LQLFQQPEVR MMLFSFGARE AMHIASYSHL ISTLNLPDVT YQEFLKYKAM KDKHEFVFNS 

       190        200        210        220        230        240 
RFKSTTVGRF FNYLLFGYDT HLEEIAVKIA LFSAFIEGVQ LFSSFIMLLN FTRHGLMKKM 

       250        260        270        280        290        300 
GQIIQWSIAD ETHHTNSMME LFSTLVVENK SHIRLGVLEA RVRDTARKIV QLEDGFIDLA 

       310        320        330        340        350        360 
FSMGEMRQLT ADDVKSYIRY ITNRRLQTMG YLPLYSVVEN PLPWVEDLLN APSHTNFFEN 

       370 
KPTEYAKASL TGDWPW 

« Hide

References

[1]"Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ643392 Genomic DNA. Translation: ABF82078.1.
RefSeqYP_654620.1. NC_008187.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4156298.

Phylogenomic databases

ProtClustDBCLSP2511500.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_IIV3
AccessionPrimary (citable) accession number: Q197B2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways