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Protein

Probable ribonucleoside-diphosphate reductase small subunit 048L

Gene

IIV3-048L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Iron 1By similarity
Metal bindingi140 – 1401Iron 1By similarity
Metal bindingi140 – 1401Iron 2By similarity
Metal bindingi143 – 1431Iron 1By similarity
Active sitei147 – 1471By similarity
Metal bindingi217 – 2171Iron 2By similarity
Metal bindingi251 – 2511Iron 2By similarity
Metal bindingi254 – 2541Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonucleoside-diphosphate reductase small subunit 048L (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:IIV3-048L
OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Taxonomic identifieri345201 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
ProteomesiUP000001358 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Probable ribonucleoside-diphosphate reductase small subunit 048LPRO_0000376909Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00526.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q197B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYEHLWLTA YGCLAVVGAV VVYCAIKQSL VTNWWFYGSI YPQVKLMADR
60 70 80 90 100
TTFKPFEYPG CYDKWDTHEH AHWSFKELNM QDDVHDWHNR LSEAEKTFLV
110 120 130 140 150
QILRFFTQGD VDVAVGYVQY LQLFQQPEVR MMLFSFGARE AMHIASYSHL
160 170 180 190 200
ISTLNLPDVT YQEFLKYKAM KDKHEFVFNS RFKSTTVGRF FNYLLFGYDT
210 220 230 240 250
HLEEIAVKIA LFSAFIEGVQ LFSSFIMLLN FTRHGLMKKM GQIIQWSIAD
260 270 280 290 300
ETHHTNSMME LFSTLVVENK SHIRLGVLEA RVRDTARKIV QLEDGFIDLA
310 320 330 340 350
FSMGEMRQLT ADDVKSYIRY ITNRRLQTMG YLPLYSVVEN PLPWVEDLLN
360 370
APSHTNFFEN KPTEYAKASL TGDWPW
Length:376
Mass (Da):44,070
Last modified:July 11, 2006 - v1
Checksum:i8D3716EF3DA19D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA. Translation: ABF82078.1.
RefSeqiYP_654620.1. NC_008187.1.

Genome annotation databases

GeneIDi4156298.
KEGGivg:4156298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA. Translation: ABF82078.1.
RefSeqiYP_654620.1. NC_008187.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4156298.
KEGGivg:4156298.

Phylogenomic databases

KOiK00526.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
    Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
    J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_IIV3
AccessioniPrimary (citable) accession number: Q197B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: April 29, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.