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Protein

Mitochondrial import receptor subunit TOM20 homolog

Gene

tomm-20

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (PubMed:21264209).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor TOM20
Translocase of outer mitochondrial membrane protein 20
Gene namesi
Name:tomm-20Imported
ORF Names:F23H12.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF23H12.2; CE05705; WBGene00009092; tomm-20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei13 – 3119HelicalSequence analysisAdd
BLAST
Topological domaini32 – 188157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Mitochondrial import receptor subunit TOM20 homologPRO_0000051542Add
BLAST

Proteomic databases

EPDiQ19766.
PaxDbiQ19766.

Expressioni

Gene expression databases

BgeeiWBGene00009092.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
prx-19P344533EBI-320312,EBI-320322

Protein-protein interaction databases

BioGridi44714. 5 interactions.
DIPiDIP-26815N.
IntActiQ19766. 2 interactions.
MINTiMINT-1041836.
STRINGi6239.F23H12.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ19766.
SMRiQ19766. Positions 66-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4056. Eukaryota.
ENOG4111NAH. LUCA.
GeneTreeiENSGT00390000011698.
HOGENOMiHOG000006671.
InParanoidiQ19766.
KOiK17770.
OMAiHKRINAP.
OrthoDBiEOG091G0Z80.
PhylomeDBiQ19766.

Family and domain databases

Gene3Di1.20.960.10. 1 hit.
InterProiIPR002056. MAS20.
IPR022422. MAS20_rcpt_metazoan.
IPR023392. Tom20_dom.
[Graphical view]
PANTHERiPTHR12430. PTHR12430. 1 hit.
PfamiPF02064. MAS20. 1 hit.
[Graphical view]
PRINTSiPR01989. EUOM20RECPTR.
PR00351. OM20RECEPTOR.
SUPFAMiSSF47157. SSF47157. 1 hit.
TIGRFAMsiTIGR00985. 3a0801s04tom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTILGFNK SNVVLAAGIA GAAFLGYCIY FDHKRINAPD YKDKIRQKRR
60 70 80 90 100
AQAGAGGMAP RRPAAAGNDA APDVTDPSQM QRFFLQEVQL GEELMAAGNV
110 120 130 140 150
DEGAVHIANA VMLCGESQQL LSIFQQTLSE DQFRAVVQQL PSTRERLAEM
160 170 180
FGAKADEAEN EPPMVQYLGD GPPPAQIQEL IDDTDDLE
Length:188
Mass (Da):20,426
Last modified:November 1, 1996 - v1
Checksum:i5A7E0E00C408F2D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74472 Genomic DNA. Translation: CAA98945.1.
PIRiT21317.
RefSeqiNP_506092.1. NM_073691.5.
UniGeneiCel.3921.

Genome annotation databases

EnsemblMetazoaiF23H12.2; F23H12.2; WBGene00009092.
GeneIDi179691.
KEGGicel:CELE_F23H12.2.
UCSCiF23H12.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74472 Genomic DNA. Translation: CAA98945.1.
PIRiT21317.
RefSeqiNP_506092.1. NM_073691.5.
UniGeneiCel.3921.

3D structure databases

ProteinModelPortaliQ19766.
SMRiQ19766. Positions 66-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44714. 5 interactions.
DIPiDIP-26815N.
IntActiQ19766. 2 interactions.
MINTiMINT-1041836.
STRINGi6239.F23H12.2.1.

Proteomic databases

EPDiQ19766.
PaxDbiQ19766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF23H12.2; F23H12.2; WBGene00009092.
GeneIDi179691.
KEGGicel:CELE_F23H12.2.
UCSCiF23H12.2.1. c. elegans.

Organism-specific databases

CTDi179691.
WormBaseiF23H12.2; CE05705; WBGene00009092; tomm-20.

Phylogenomic databases

eggNOGiKOG4056. Eukaryota.
ENOG4111NAH. LUCA.
GeneTreeiENSGT00390000011698.
HOGENOMiHOG000006671.
InParanoidiQ19766.
KOiK17770.
OMAiHKRINAP.
OrthoDBiEOG091G0Z80.
PhylomeDBiQ19766.

Miscellaneous databases

PROiQ19766.

Gene expression databases

BgeeiWBGene00009092.

Family and domain databases

Gene3Di1.20.960.10. 1 hit.
InterProiIPR002056. MAS20.
IPR022422. MAS20_rcpt_metazoan.
IPR023392. Tom20_dom.
[Graphical view]
PANTHERiPTHR12430. PTHR12430. 1 hit.
PfamiPF02064. MAS20. 1 hit.
[Graphical view]
PRINTSiPR01989. EUOM20RECPTR.
PR00351. OM20RECEPTOR.
SUPFAMiSSF47157. SSF47157. 1 hit.
TIGRFAMsiTIGR00985. 3a0801s04tom. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTOM20_CAEEL
AccessioniPrimary (citable) accession number: Q19766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.