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Protein

Mitochondrial import receptor subunit TOM20 homolog

Gene

tomm-20

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (PubMed:21264209).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor TOM20
Translocase of outer mitochondrial membrane protein 20
Gene namesi
Name:tomm-20Imported
ORF Names:F23H12.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF23H12.2 ; CE05705 ; WBGene00009092 ; tomm-20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei13 – 31HelicalSequence analysisAdd BLAST19
Topological domaini32 – 188CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515421 – 188Mitochondrial import receptor subunit TOM20 homologAdd BLAST188

Proteomic databases

EPDiQ19766
PaxDbiQ19766
PeptideAtlasiQ19766
PRIDEiQ19766

Expressioni

Gene expression databases

BgeeiWBGene00009092

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
prx-19P344533EBI-320312,EBI-320322

Protein-protein interaction databases

BioGridi44714, 5 interactors
DIPiDIP-26815N
IntActiQ19766, 2 interactors
STRINGi6239.F23H12.2.1

Structurei

3D structure databases

ProteinModelPortaliQ19766
SMRiQ19766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4056 Eukaryota
ENOG4111NAH LUCA
GeneTreeiENSGT00390000011698
HOGENOMiHOG000006671
InParanoidiQ19766
KOiK17770
OMAiHKRINAP
OrthoDBiEOG091G0Z80
PhylomeDBiQ19766

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056 MAS20
IPR022422 MAS20_rcpt_metazoan
IPR023392 Tom20_dom_sf
PANTHERiPTHR12430 PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064 MAS20, 1 hit
PIRSFiPIRSF037707 MAS20_rcpt, 1 hit
PRINTSiPR01989 EUOM20RECPTR
PR00351 OM20RECEPTOR
SUPFAMiSSF47157 SSF47157, 1 hit
TIGRFAMsiTIGR00985 3a0801s04tom, 1 hit

Sequencei

Sequence statusi: Complete.

Q19766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTILGFNK SNVVLAAGIA GAAFLGYCIY FDHKRINAPD YKDKIRQKRR
60 70 80 90 100
AQAGAGGMAP RRPAAAGNDA APDVTDPSQM QRFFLQEVQL GEELMAAGNV
110 120 130 140 150
DEGAVHIANA VMLCGESQQL LSIFQQTLSE DQFRAVVQQL PSTRERLAEM
160 170 180
FGAKADEAEN EPPMVQYLGD GPPPAQIQEL IDDTDDLE
Length:188
Mass (Da):20,426
Last modified:November 1, 1996 - v1
Checksum:i5A7E0E00C408F2D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74472 Genomic DNA Translation: CAA98945.1
PIRiT21317
RefSeqiNP_506092.1, NM_073691.5
UniGeneiCel.3921

Genome annotation databases

EnsemblMetazoaiF23H12.2; F23H12.2; WBGene00009092
GeneIDi179691
KEGGicel:CELE_F23H12.2
UCSCiF23H12.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTOM20_CAEEL
AccessioniPrimary (citable) accession number: Q19766
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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