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Protein

Innexin-3

Gene

inx-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Structural components of the gap junctions.

GO - Molecular functioni

GO - Biological processi

  • embryonic morphogenesis Source: WormBase
  • ion transport Source: UniProtKB-KW
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.25.1.1. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-3
Alternative name(s):
Protein opu-3
Gene namesi
Name:inx-3
Synonyms:opu-3
ORF Names:F22F4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF22F4.2; CE33055; WBGene00002125; inx-3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei104 – 12421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei193 – 21321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • gap junction Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Innexin-3PRO_0000208506Add
BLAST

Proteomic databases

EPDiQ19746.
PaxDbiQ19746.

Interactioni

Protein-protein interaction databases

IntActiQ19746. 1 interaction.
MINTiMINT-3386782.
STRINGi6239.F22F4.2.2.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGA4. Eukaryota.
ENOG410XT2D. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiQ19746.
OMAiEEGHHEH.
PhylomeDBiQ19746.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVPFIDRW LSETFKPKTF DDAVDRLSYV TTATLLAFFS IMVSCKQYVG
60 70 80 90 100
SAIQCWMPME FKGGWEQYAE DYCFIQNTFF IPERSEIPGD VEDRQKAEIG
110 120 130 140 150
YYQWVPIVLA IQAFMFYLPS WIWSSLYKQC GLDFPSVISE AEALRSQDSE
160 170 180 190 200
TRTKGVNKLV DFIGDILDTR SKNEYGRFYC YRFGKGLGSM TSMLYICIKL
210 220 230 240 250
MYLANVFVQF IILNKFLGNE TFLWGFHTFA DLYAGREWQD SGVFPRVTLC
260 270 280 290 300
DFSVRKLANV HRYTVQCVLM INMFNEKIYL FIWFWFVFVL ITTFINTLCT
310 320 330 340 350
IYRLSFDSSR HNYIRSLLSG PVNNFKDEKA MIASFANNGL KQDGVLLMRF
360 370 380 390 400
IDDHAGAMVT KEICEELFKK HGENLQHNRD FHHGHSTKST SPGLEEGHHE
410 420
HLYTPEKMKL MAPDYPIKHA
Length:420
Mass (Da):48,917
Last modified:December 1, 2000 - v2
Checksum:i8B8B6E65924966B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59211 mRNA. Translation: AAB09670.1.
FO080452 Genomic DNA. Translation: CCD63822.1.
PIRiT16141.
RefSeqiNP_509002.2. NM_076601.6.
UniGeneiCel.19710.

Genome annotation databases

EnsemblMetazoaiF22F4.2; F22F4.2; WBGene00002125.
GeneIDi180866.
KEGGicel:CELE_F22F4.2.
UCSCiF22F4.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59211 mRNA. Translation: AAB09670.1.
FO080452 Genomic DNA. Translation: CCD63822.1.
PIRiT16141.
RefSeqiNP_509002.2. NM_076601.6.
UniGeneiCel.19710.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ19746. 1 interaction.
MINTiMINT-3386782.
STRINGi6239.F22F4.2.2.

Protein family/group databases

TCDBi1.A.25.1.1. the gap junction-forming innexin (innexin) family.

Proteomic databases

EPDiQ19746.
PaxDbiQ19746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF22F4.2; F22F4.2; WBGene00002125.
GeneIDi180866.
KEGGicel:CELE_F22F4.2.
UCSCiF22F4.2. c. elegans.

Organism-specific databases

CTDi180866.
WormBaseiF22F4.2; CE33055; WBGene00002125; inx-3.

Phylogenomic databases

eggNOGiENOG410IGA4. Eukaryota.
ENOG410XT2D. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiQ19746.
OMAiEEGHHEH.
PhylomeDBiQ19746.

Miscellaneous databases

NextBioi911322.
PROiQ19746.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling."
    Starich T.A., Lee R.Y., Panzarella C., Avery L., Shaw J.E.
    J. Cell Biol. 134:537-548(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Innexin-3 forms connexin-like intercellular channels."
    Landesman Y., White T.W., Starich T.A., Shaw J.E., Goodenough D.A., Paul D.L.
    J. Cell Sci. 112:2391-2396(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiINX3_CAEEL
AccessioniPrimary (citable) accession number: Q19746
Secondary accession number(s): Q17393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 16, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.