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Protein

Tyrosine-protein kinase

Gene

kin-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ19726.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:kin-14Imported
ORF Names:CELE_F22D6.1Imported, F22D6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF22D6.1; CE05682; WBGene00002198; kin-14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ19726.
PaxDbiQ19726.

Expressioni

Gene expression databases

BgeeiWBGene00002198.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ19726. 1 interactor.
STRINGi6239.F22D6.1.

Structurei

3D structure databases

ProteinModelPortaliQ19726.
SMRiQ19726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 122SH2InterPro annotationAdd BLAST93
Domaini134 – 400Protein kinaseInterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ19726.
KOiK08889.
OMAiRFCIESA.
OrthoDBiEOG091G0AGS.
PhylomeDBiQ19726.

Family and domain databases

CDDicd10361. SH2_Fps_family. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035849. Fes/Fps/Fer_SH2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q19726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNGNATDS SSSTSSMTEN SDGQKQNNEW FHGVLQRQDA DELLVKPGSF
60 70 80 90 100
LLRASEVHGK MSMILSVRHD GKLHNIAVNS DTGENFWFEG HREKSIDQLV
110 120 130 140 150
QWHMTTSTPI TKTSGVKLKY PIGKADWIIS HENVIFIKKL GEGAFGEVSL
160 170 180 190 200
AECEIGGRKV ETAVKTMRCQ MTRDTRAAFM KEARLMRKYS HPHIVRIIGK
210 220 230 240 250
IIVKHLPKVG LAVDAHPLMI VMEMCPHGSL LSFLRKNKGK TTLSERLRFC
260 270 280 290 300
IESADGLAYL EKKQCLHRDI AARNCLLSIT DQIKISDFGL SDDKRTEMHD
310 320 330 340 350
DTLDKVPVKW LAPEVMQDKL YSLKSDVWAF GVLMWEIYAD GADPYPGMTN
360 370 380 390 400
LVTRAKIFCD DYRMTFPETT PPTISEIALK QCWAKLPSDR ATMKTVHHKL
410
KDLSMPMSDV SFSMKMKR
Length:418
Mass (Da):47,294
Last modified:November 1, 1996 - v1
Checksum:i7B8A7ACF1D1D039B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA95813.1.
PIRiT21258.
RefSeqiNP_492004.1. NM_059603.6.
UniGeneiCel.18456.

Genome annotation databases

EnsemblMetazoaiF22D6.1; F22D6.1; WBGene00002198.
GeneIDi172440.
KEGGicel:CELE_F22D6.1.
UCSCiF22D6.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ19726_CAEEL
AccessioniPrimary (citable) accession number: Q19726
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported