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Protein

Tyrosine-protein kinase

Gene

kin-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ19726.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:kin-14Imported
ORF Names:CELE_F22D6.1Imported, F22D6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF22D6.1; CE05682; WBGene00002198; kin-14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ19726.
PaxDbiQ19726.
PRIDEiQ19726.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ19726. 1 interaction.
STRINGi6239.F22D6.1.

Structurei

3D structure databases

ProteinModelPortaliQ19726.
SMRiQ19726. Positions 29-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12293SH2InterPro annotationAdd
BLAST
Domaini134 – 400267Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ19726.
OMAiRFCIESA.
OrthoDBiEOG708VXW.
PhylomeDBiQ19726.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNGNATDS SSSTSSMTEN SDGQKQNNEW FHGVLQRQDA DELLVKPGSF
60 70 80 90 100
LLRASEVHGK MSMILSVRHD GKLHNIAVNS DTGENFWFEG HREKSIDQLV
110 120 130 140 150
QWHMTTSTPI TKTSGVKLKY PIGKADWIIS HENVIFIKKL GEGAFGEVSL
160 170 180 190 200
AECEIGGRKV ETAVKTMRCQ MTRDTRAAFM KEARLMRKYS HPHIVRIIGK
210 220 230 240 250
IIVKHLPKVG LAVDAHPLMI VMEMCPHGSL LSFLRKNKGK TTLSERLRFC
260 270 280 290 300
IESADGLAYL EKKQCLHRDI AARNCLLSIT DQIKISDFGL SDDKRTEMHD
310 320 330 340 350
DTLDKVPVKW LAPEVMQDKL YSLKSDVWAF GVLMWEIYAD GADPYPGMTN
360 370 380 390 400
LVTRAKIFCD DYRMTFPETT PPTISEIALK QCWAKLPSDR ATMKTVHHKL
410
KDLSMPMSDV SFSMKMKR
Length:418
Mass (Da):47,294
Last modified:November 1, 1996 - v1
Checksum:i7B8A7ACF1D1D039B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA95813.1.
PIRiT21258.
RefSeqiNP_492004.1. NM_059603.6.
UniGeneiCel.18456.

Genome annotation databases

EnsemblMetazoaiF22D6.1; F22D6.1; WBGene00002198.
GeneIDi172440.
KEGGicel:CELE_F22D6.1.
UCSCiF22D6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA95813.1.
PIRiT21258.
RefSeqiNP_492004.1. NM_059603.6.
UniGeneiCel.18456.

3D structure databases

ProteinModelPortaliQ19726.
SMRiQ19726. Positions 29-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ19726. 1 interaction.
STRINGi6239.F22D6.1.

Proteomic databases

EPDiQ19726.
PaxDbiQ19726.
PRIDEiQ19726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF22D6.1; F22D6.1; WBGene00002198.
GeneIDi172440.
KEGGicel:CELE_F22D6.1.
UCSCiF22D6.1. c. elegans.

Organism-specific databases

CTDi172440.
WormBaseiF22D6.1; CE05682; WBGene00002198; kin-14.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ19726.
OMAiRFCIESA.
OrthoDBiEOG708VXW.
PhylomeDBiQ19726.

Enzyme and pathway databases

SignaLinkiQ19726.

Miscellaneous databases

PROiQ19726.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ19726_CAEEL
AccessioniPrimary (citable) accession number: Q19726
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.