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Protein

Asparagine--tRNA ligase, cytoplasmic

Gene

nars-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.Curated1 Publication

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

GO - Biological processi

  • asparaginyl-tRNA aminoacylation Source: InterPro
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • translation Source: UniProtKB

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligase, cytoplasmic (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:nars-1Imported
Synonyms:nrs-1Imported
ORF Names:F22D6.3Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF22D6.3a ; CE05684 ; WBGene00003815 ; nars-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001764951 – 545Asparagine--tRNA ligase, cytoplasmicAdd BLAST545

Proteomic databases

EPDiQ19722
PaxDbiQ19722
PeptideAtlasiQ19722
PRIDEiQ19722

Expressioni

Gene expression databases

BgeeiWBGene00003815

Interactioni

Protein-protein interaction databases

STRINGi6239.F22D6.3a.1

Structurei

3D structure databases

ProteinModelPortaliQ19722
SMRiQ19722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0555 Eukaryota
COG0017 LUCA
GeneTreeiENSGT00550000074893
HOGENOMiHOG000226035
InParanoidiQ19722
KOiK01893
OMAiYMQRCPE
OrthoDBiEOG091G065Q
PhylomeDBiQ19722

Family and domain databases

InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004522 Asn-tRNA-ligase
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR01042 TRNASYNTHASP
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00457 asnS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q19722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLYIDTDA GSDQHPGTEA QPLATLVQAM LISKNSGEFL MKKKSEEGES
60 70 80 90 100
WEPAAKAAIK KAVKKYEAEV KKLEKAGCRE KEAEEAQHAA LEEAKKITFS
110 120 130 140 150
LDKSLPEAKV IKIGESVQHR DQRVSIKAWV HRLRRQGKSL MFLVLRDGYG
160 170 180 190 200
FLQCVLNDKL CQSYDAVTLS TETSVQVYGI IKALPDGKSA PDGHELTVDY
210 220 230 240 250
WEVIGKAPAG GIDNVLNESA GVDVMLDNRH LVIRGENASR ILRIRAAATR
260 270 280 290 300
AMRDHFFAAG YTEVAPPTLV QTQVEGGSTL FGLDYYGEPA YLTQSSQLYL
310 320 330 340 350
ETCNAALGDV YCISQSYRAE KSRTRRHLSE YQHVEAECAF ITFDQLMDRI
360 370 380 390 400
EALVCDTVDR LLADPVTKSL IEFVNPGYKA PARPFKRMPY KEAIEWLQKN
410 420 430 440 450
DVRNEMGEKF VYGEDIAEAA ERRMTDTIGV PILLNRFPHG IKAFYMPRCA
460 470 480 490 500
DDNELTESVD LLMPGVGEIV GGSMRIWKED QLLAAFEKGG LDSKNYYWYM
510 520 530 540
DQRKYGSVPH GGYGLGLERF ICWLTDTNHI RDVCLYPRFV GRCAP
Length:545
Mass (Da):61,186
Last modified:November 1, 1996 - v1
Checksum:i53FADA68ECB81BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71262 Genomic DNA Translation: CAA95808.1
PIRiT21253
RefSeqiNP_001021405.1, NM_001026234.4
UniGeneiCel.23239

Genome annotation databases

EnsemblMetazoaiF22D6.3a; F22D6.3a; WBGene00003815
GeneIDi172442
KEGGicel:CELE_F22D6.3
UCSCiF22D6.3a.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSYNC_CAEEL
AccessioniPrimary (citable) accession number: Q19722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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