Reviewed, UniProtKB/Swiss-Prot Q19722 (SYNC_CAEEL)

Names and origin

Protein names

Recommended name:
    Asparaginyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.22
Alternative name(s):
    Asparagine--tRNA ligase
      Short name=AsnRS

Gene names

Name:	nrs-1
ORF Names:	F22D6.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	545 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC aspartate-tRNA ligase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 545	545	Asparaginyl-tRNA synthetase, cytoplasmic		PRO_0000176495

Sequences

	Sequence		Length	Mass (Da)
	Q19722-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 53FADA68ECB81BAC	FASTA	545	61,186
	10 20 30 40 50 60 MSKLYIDTDA GSDQHPGTEA QPLATLVQAM LISKNSGEFL MKKKSEEGES WEPAAKAAIK 70 80 90 100 110 120 KAVKKYEAEV KKLEKAGCRE KEAEEAQHAA LEEAKKITFS LDKSLPEAKV IKIGESVQHR 130 140 150 160 170 180 DQRVSIKAWV HRLRRQGKSL MFLVLRDGYG FLQCVLNDKL CQSYDAVTLS TETSVQVYGI 190 200 210 220 230 240 IKALPDGKSA PDGHELTVDY WEVIGKAPAG GIDNVLNESA GVDVMLDNRH LVIRGENASR 250 260 270 280 290 300 ILRIRAAATR AMRDHFFAAG YTEVAPPTLV QTQVEGGSTL FGLDYYGEPA YLTQSSQLYL 310 320 330 340 350 360 ETCNAALGDV YCISQSYRAE KSRTRRHLSE YQHVEAECAF ITFDQLMDRI EALVCDTVDR 370 380 390 400 410 420 LLADPVTKSL IEFVNPGYKA PARPFKRMPY KEAIEWLQKN DVRNEMGEKF VYGEDIAEAA 430 440 450 460 470 480 ERRMTDTIGV PILLNRFPHG IKAFYMPRCA DDNELTESVD LLMPGVGEIV GGSMRIWKED 490 500 510 520 530 540 QLLAAFEKGG LDSKNYYWYM DQRKYGSVPH GGYGLGLERF ICWLTDTNHI RDVCLYPRFV GRCAP

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z71262 Genomic DNA. Translation: CAA95808.1.
PIR	T21253.
RefSeq	NP_001021405.1.
UniGene	Cel.23239
3D structure databases
HSSP	HSSP built from PDB template 1B8A based on UniProtKB Q52428.
ModBase	Search...
Protein-protein interaction databases
STRING	Q19722.
Proteomic databases
PRIDE	Q19722.
Genome annotation databases
Ensembl	F22D6.3a.1; F22D6.3a.1; F22D6.3; Caenorhabditis elegans. [Genome view] F22D6.3a.2; F22D6.3a.2; F22D6.3; Caenorhabditis elegans. [Genome view]
GeneID	172442.
KEGG	cel:F22D6.3.
UCSC	F22D6.3a.1. c. elegans.
Organism-specific databases
CTD	172442.
WormBase	WBGene00003815. nrs-1.
WormPep	F22D6.3. CE05684. [WorfDB]
Phylogenomic databases
OMA	SEYTHIE.
Enzyme and pathway databases
BRENDA	6.1.1.22. 672.
Gene expression databases
ArrayExpress	Q19722.
Family and domain databases
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00457. asnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	875533.

Entry information

Entry name

SYNC_CAEEL

Accession

Primary (citable) accession number: Q19722

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project