Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein ceh-38

Gene

ceh-38

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable DNA-binding regulatory protein involved in cell-fate specification.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi308 – 394CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi427 – 486HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ceh-38
Gene namesi
Name:ceh-38
ORF Names:F22D3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF22D3.1a; CE27137; WBGene00000459; ceh-38.
F22D3.1b; CE29772; WBGene00000459; ceh-38.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024091 – 641Homeobox protein ceh-38Add BLAST641

Proteomic databases

EPDiQ19720.
PaxDbiQ19720.
PeptideAtlasiQ19720.
PRIDEiQ19720.

PTM databases

iPTMnetiQ19720.

Expressioni

Tissue specificityi

Expressed in the embryo. After gastrulation, expressed in almost all cells. During larval and adult stages, expressed in the dorsal and ventral nerve cord, head and tail neurons, pharynx, gut and head.1 Publication

Developmental stagei

Expression starts during embryogenesis and continues into adulthood.1 Publication

Gene expression databases

BgeeiWBGene00000459.

Interactioni

Protein-protein interaction databases

IntActiQ19720. 2 interactors.
STRINGi6239.F22D3.1b.

Structurei

3D structure databases

ProteinModelPortaliQ19720.
SMRiQ19720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 108Ser-richAdd BLAST48
Compositional biasi572 – 626Glu-richAdd BLAST55

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000019385.
InParanoidiQ19720.
OMAiNVRTHRR.
OrthoDBiEOG091G0E7H.

Family and domain databases

InterProiView protein in InterPro
IPR003350. CUT_dom.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
PfamiView protein in Pfam
PF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q19720-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSRTAATS TNGTEKSRRR NTDYLQIDPS STFINNTGRG FAEELPENFL
60 70 80 90 100
DTISPHPITP SASTSSATSA TEEPATSSAP QLASLAPMSM SSEQPSSSFS
110 120 130 140 150
SASLLSSSYE TIKNEPEFSG STAGLLSPLH VDSRRRESHD FNTSPYIKEE
160 170 180 190 200
EDLDGSHLLM GGIRPDTPTN DRSTDLGSIS SLLNEDHHTN TIGQSPSPRS
210 220 230 240 250
TFGSDPTPMI QRQLIKNEDG VSPGSMGFSK NHQGYQKPRN GDRMEYEKAP
260 270 280 290 300
YQRNSRKQKK PLGLLNQALS SVISTPTISS SNIPTPPSAH IAQPRRIYST
310 320 330 340 350
QDSNDPLNAE IGDDIYIDTK DLCKRIAFEL KNHSIPQAIF AERILCRSQG
360 370 380 390 400
TLSDLLRNPK PWNKLKSGRE TFRRMYNWVA QPLATRLAIL DMKTEDVNRA
410 420 430 440 450
SGMSPPTPAQ NVRTHRRSTS DHDGPVSKRP RLVFTDIQKR TLQAIFKETQ
460 470 480 490 500
RPSREMQQTI AEHLRLDLST VANFFMNARR RSRLGGNIDE PTPFQQVKNI
510 520 530 540 550
SPPPVGDTSD ALLNGDDHVP LLNTVMAEMY KEGAIATSNH SAEQREMIER
560 570 580 590 600
GFGVSIPGPS HSGELLNGDS HEDDEELDEL NDSELAYEED VEIGDEEEED
610 620 630 640
EEQANGDILP TPKVEELEEK TVIKEEAPDD GEYGATKLAA N
Note: No experimental confirmation available.
Length:641
Mass (Da):70,816
Last modified:May 27, 2002 - v2
Checksum:i9A57D865682D184C
GO
Isoform a (identifier: Q19720-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-263: NSRKQKKPLG → S

Note: No experimental confirmation available.
Show »
Length:632
Mass (Da):69,766
Checksum:iD6C6420BD989DC34
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002313254 – 263NSRKQKKPLG → S in isoform a. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080140 Genomic DNA. Translation: CCD61546.1.
FO080140 Genomic DNA. Translation: CCD61547.1.
RefSeqiNP_741017.1. NM_171016.3. [Q19720-1]
NP_741018.1. NM_171852.1. [Q19720-2]
UniGeneiCel.5360.

Genome annotation databases

EnsemblMetazoaiF22D3.1b; F22D3.1b; WBGene00000459. [Q19720-1]
GeneIDi174136.
KEGGicel:CELE_F22D3.1.
UCSCiF22D3.1b. c. elegans. [Q19720-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHM38_CAEEL
AccessioniPrimary (citable) accession number: Q19720
Secondary accession number(s): Q95QJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 27, 2002
Last modified: May 10, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families