Q19706 (EIF3G_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit G
Short name=eIF3g

Alternative name(s):
Eukaryotic translation initiation factor 3 RNA-binding subunit
Short name=eIF-3 RNA-binding subunit
Eukaryotic translation initiation factor 3 subunit 4

Gene names

Name:	eif-3.G
ORF Names:	F22B5.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can bind 18S rRNA By similarity. HAMAP-Rule MF_03006
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.
Subcellular location	Cytoplasm By similarity.
Disruption phenotype	Abnormal morphology (dumpy phenotype), slow growth, sterile and in severe cases embryonic lethal. Ref.2
Sequence similarities	Belongs to the eIF-3 subunit G family. Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Eukaryotic translation initiation factor 3 subunit G HAMAP-Rule MF_03006		PRO_0000123512
Regions
	Domain	176 – 254	79	RRM

Sequences

	Sequence		Length	Mass (Da)
	Q19706 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BEED1E4ADED2F33B	FASTA	256	29,289
	10 20 30 40 50 60 MAPAPEVVSW AEAVEQDNAP HIQEGADGTR TETAFTEVDG VRWKVVTQFK VINKRVPKVV 70 80 90 100 110 120 ADRKKWVKFG SCKGEPAGPQ VATTYVAEEV DMQFTRNRAG EQILDVQEDK QTAKTTSREH 130 140 150 160 170 180 CRHCKGNDHW STHCPYKVMY QLDEEADADK DTEKDRMAMG MRPDGRQIDR NRSDENTCRV 190 200 210 220 230 240 TNLPQEMNED ELRDLFGKIG RVIRIFIARD KVTGLPKGFA FVTFESRDDA ARAIAELNDI 250 RMYHMVLKVE WTRPSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi." Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M., Welchman D.P., Zipperlen P., Ahringer J. Nature 421:231-237(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50044 Genomic DNA. Translation: CAA90354.1.
PIR	T21238.
RefSeq	NP_495778.1. NM_063377.3.
3D structure databases
ProteinModelPortal	Q19706.
SMR	Q19706. Positions 138-255.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F22B5.2.
Proteomic databases
PaxDb	Q19706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F22B5.2.1; F22B5.2.1; F22B5.2. F22B5.2.2; F22B5.2.2; F22B5.2. F22B5.2.3; F22B5.2.3; F22B5.2.
GeneID	174346.
KEGG	cel:CELE_F22B5.2.
Organism-specific databases
CTD	174346.
WormBase	F22B5.2; CE02197; WBGene00001230; eif-3.G.
Phylogenomic databases
eggNOG	COG0724.
GeneTree	ENSGT00510000047802.
HOGENOM	HOG000239560.
InParanoid	Q19706.
KO	K03248.
OMA	TRTETAF.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
HAMAP	MF_03006. eIF3g.
InterPro	IPR024675. eIF3g_N. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR017334. Transl_init_eIF-3_G. IPR001878. Znf_CCHC. [Graphical view]
PANTHER	PTHR10352. PTHR10352. 1 hit.
Pfam	PF12353. eIF3g. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view]
PIRSF	PIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
SMART	SM00360. RRM. 1 hit. SM00343. ZnF_C2HC. 1 hit. [Graphical view]
PROSITE	PS50102. RRM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	883648.

Entry information

Entry name

EIF3G_CAEEL

Accession

Primary (citable) accession number: Q19706

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project