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Protein

Putative ubiquitin thioesterase 232R

Gene

IIV3-084L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei598 – 5981Sequence Analysis
Active sitei601 – 6011NucleophileBy similarity
Active sitei718 – 7181Sequence Analysis

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA-templated transcription, termination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin thioesterase 232R (EC:3.4.19.12)
Gene namesi
ORF Names:IIV3-084L
OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Taxonomic identifieri345201 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
ProteomesiUP000001358 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 844844Putative ubiquitin thioesterase 232RPRO_0000377773Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini590 – 725136OTUPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi137 – 21882Arg/Ser-richAdd
BLAST
Compositional biasi347 – 3515Poly-Pro
Compositional biasi428 – 45225Pro-richAdd
BLAST
Compositional biasi747 – 80660Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR003323. OTU.
IPR011112. Rho_N.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
PF07498. Rho_N. 1 hit.
[Graphical view]
SMARTiSM00959. Rho_N. 3 hits.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q196X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDVDLKTCQ KSSKFKKKDI VELGKQCGVN PYLSNGKEKS RTVICTEIVA
60 70 80 90 100
SYNPPPGSSQ GDDSEHESIS QVNNIPNRNE KFLPKSKYPT YTQVLNMEKR
110 120 130 140 150
QLKALAKKLG LEYKKQTEQQ LQGAINLKIK TLEGLNSSTR SRSPSVRSRC
160 170 180 190 200
RSPSPRAPSV RSRLPSTRSR CRSPSPRAPS TRSRSPSVRS RCRSPSPRAP
210 220 230 240 250
SVRSRSPSRQ SVRQSSESAD EAEQVALETM KTAHLRMLAT TLGASTVTGM
260 270 280 290 300
KKKDLIDYIK SRRKSPSPSP VPPSTRCDPT TTAPPMEDLF KKKVDELKTM
310 320 330 340 350
AKNAGFVRWN GKTLSKMNKS DLVDFLLNGM NRPSPSLPQS RSRTRSPPPP
360 370 380 390 400
PRSRSPSVGS PSVRDGGAGR RRLPELTRAQ LTAMKVVDLK AMATELGLTR
410 420 430 440 450
YRGMNRTQMR KGDVINFIIE TQKKQKTPSP SPTPPSPVPS VVGSRRPKSP
460 470 480 490 500
LPYKSRDFVA LADDDSEPGV EVQKKMGKSG EREPKSVPNV RIIPSEIPAP
510 520 530 540 550
TEGSLRSRLS TQQQTQQSVV YEDPNESIKP EESVRAPKLS VVDPQLSRKT
560 570 580 590 600
LKPLPSLVVT DQPSKQPELP KYKGRTPYTD LEQLAQSKGY TVKQVSGDGN
610 620 630 640 650
CLFRSVCKSI RALRGEKFTH RQLRQMVVDY LRENPEFLQV YLEYVARQRD
660 670 680 690 700
NSLPSTEQYL SEMSKCGTWG DLICLKTLSE ILKVQFNLLI LNTKQFQMVS
710 720 730 740 750
SQDDYPDVIP LGYIDNYHYT SLVPIGLDSK GGAASSTTTG LKQLDGPRPP
760 770 780 790 800
ITLIPESQVP AVAATISTQQ PPSIVAPPIS VGGSQLVPSI VPQPQMPKPD
810 820 830 840
FKPVKPLSNL NELLDLMDRV KPQVYNDISQ LEKARQSIKV SLGL
Length:844
Mass (Da):93,521
Last modified:July 11, 2006 - v1
Checksum:i6E24E9C3EE3C5872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA. Translation: ABF82114.1.
RefSeqiYP_654656.1. NC_008187.1.

Genome annotation databases

GeneIDi4156295.
KEGGivg:4156295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA. Translation: ABF82114.1.
RefSeqiYP_654656.1. NC_008187.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4156295.
KEGGivg:4156295.

Family and domain databases

InterProiIPR003323. OTU.
IPR011112. Rho_N.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
PF07498. Rho_N. 1 hit.
[Graphical view]
SMARTiSM00959. Rho_N. 3 hits.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
    Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
    J. Virol. 80:8439-8449(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiVF232_IIV3
AccessioniPrimary (citable) accession number: Q196X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.