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Q196X6

- VF232_IIV3

UniProt

Q196X6 - VF232_IIV3

Protein

Putative ubiquitin thioesterase 232R

Gene

IIV3-084L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei598 – 5981Sequence Analysis
    Active sitei601 – 6011NucleophileBy similarity
    Active sitei718 – 7181Sequence Analysis

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA-templated transcription, termination Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin thioesterase 232R (EC:3.4.19.12)
    Gene namesi
    ORF Names:IIV3-084L
    OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
    Taxonomic identifieri345201 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeChloriridovirus
    Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
    Culex territans [TaxID: 42431]
    Culiseta annulata [TaxID: 332058]
    Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
    Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
    Psorophora ferox [TaxID: 7183]
    ProteomesiUP000001358: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 844844Putative ubiquitin thioesterase 232RPRO_0000377773Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini590 – 725136OTUPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi137 – 21882Arg/Ser-richAdd
    BLAST
    Compositional biasi347 – 3515Poly-Pro
    Compositional biasi428 – 45225Pro-richAdd
    BLAST
    Compositional biasi747 – 80660Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR003323. OTU.
    IPR011112. Rho_N.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    PF07498. Rho_N. 1 hit.
    [Graphical view]
    SMARTiSM00959. Rho_N. 3 hits.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q196X6-1 [UniParc]FASTAAdd to Basket

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    MCDVDLKTCQ KSSKFKKKDI VELGKQCGVN PYLSNGKEKS RTVICTEIVA    50
    SYNPPPGSSQ GDDSEHESIS QVNNIPNRNE KFLPKSKYPT YTQVLNMEKR 100
    QLKALAKKLG LEYKKQTEQQ LQGAINLKIK TLEGLNSSTR SRSPSVRSRC 150
    RSPSPRAPSV RSRLPSTRSR CRSPSPRAPS TRSRSPSVRS RCRSPSPRAP 200
    SVRSRSPSRQ SVRQSSESAD EAEQVALETM KTAHLRMLAT TLGASTVTGM 250
    KKKDLIDYIK SRRKSPSPSP VPPSTRCDPT TTAPPMEDLF KKKVDELKTM 300
    AKNAGFVRWN GKTLSKMNKS DLVDFLLNGM NRPSPSLPQS RSRTRSPPPP 350
    PRSRSPSVGS PSVRDGGAGR RRLPELTRAQ LTAMKVVDLK AMATELGLTR 400
    YRGMNRTQMR KGDVINFIIE TQKKQKTPSP SPTPPSPVPS VVGSRRPKSP 450
    LPYKSRDFVA LADDDSEPGV EVQKKMGKSG EREPKSVPNV RIIPSEIPAP 500
    TEGSLRSRLS TQQQTQQSVV YEDPNESIKP EESVRAPKLS VVDPQLSRKT 550
    LKPLPSLVVT DQPSKQPELP KYKGRTPYTD LEQLAQSKGY TVKQVSGDGN 600
    CLFRSVCKSI RALRGEKFTH RQLRQMVVDY LRENPEFLQV YLEYVARQRD 650
    NSLPSTEQYL SEMSKCGTWG DLICLKTLSE ILKVQFNLLI LNTKQFQMVS 700
    SQDDYPDVIP LGYIDNYHYT SLVPIGLDSK GGAASSTTTG LKQLDGPRPP 750
    ITLIPESQVP AVAATISTQQ PPSIVAPPIS VGGSQLVPSI VPQPQMPKPD 800
    FKPVKPLSNL NELLDLMDRV KPQVYNDISQ LEKARQSIKV SLGL 844
    Length:844
    Mass (Da):93,521
    Last modified:July 11, 2006 - v1
    Checksum:i6E24E9C3EE3C5872
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ643392 Genomic DNA. Translation: ABF82114.1.
    RefSeqiYP_654656.1. NC_008187.1.

    Genome annotation databases

    GeneIDi4156295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ643392 Genomic DNA. Translation: ABF82114.1 .
    RefSeqi YP_654656.1. NC_008187.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4156295.

    Family and domain databases

    InterProi IPR003323. OTU.
    IPR011112. Rho_N.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    PF07498. Rho_N. 1 hit.
    [Graphical view ]
    SMARTi SM00959. Rho_N. 3 hits.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
      Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
      J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiVF232_IIV3
    AccessioniPrimary (citable) accession number: Q196X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3