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Q196X6 (VF232_IIV3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length844 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Contains 1 OTU domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA-templated transcription, termination

Inferred from electronic annotation. Source: InterPro

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 844844Putative ubiquitin thioesterase 232R
PRO_0000377773

Regions

Domain590 – 725136OTU
Compositional bias137 – 21882Arg/Ser-rich
Compositional bias347 – 3515Poly-Pro
Compositional bias428 – 45225Pro-rich
Compositional bias747 – 80660Pro-rich

Sites

Active site5981 Potential
Active site6011Nucleophile By similarity
Active site7181 Potential

Sequences

Sequence LengthMass (Da)Tools
Q196X6 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 6E24E9C3EE3C5872

FASTA84493,521
        10         20         30         40         50         60 
MCDVDLKTCQ KSSKFKKKDI VELGKQCGVN PYLSNGKEKS RTVICTEIVA SYNPPPGSSQ 

        70         80         90        100        110        120 
GDDSEHESIS QVNNIPNRNE KFLPKSKYPT YTQVLNMEKR QLKALAKKLG LEYKKQTEQQ 

       130        140        150        160        170        180 
LQGAINLKIK TLEGLNSSTR SRSPSVRSRC RSPSPRAPSV RSRLPSTRSR CRSPSPRAPS 

       190        200        210        220        230        240 
TRSRSPSVRS RCRSPSPRAP SVRSRSPSRQ SVRQSSESAD EAEQVALETM KTAHLRMLAT 

       250        260        270        280        290        300 
TLGASTVTGM KKKDLIDYIK SRRKSPSPSP VPPSTRCDPT TTAPPMEDLF KKKVDELKTM 

       310        320        330        340        350        360 
AKNAGFVRWN GKTLSKMNKS DLVDFLLNGM NRPSPSLPQS RSRTRSPPPP PRSRSPSVGS 

       370        380        390        400        410        420 
PSVRDGGAGR RRLPELTRAQ LTAMKVVDLK AMATELGLTR YRGMNRTQMR KGDVINFIIE 

       430        440        450        460        470        480 
TQKKQKTPSP SPTPPSPVPS VVGSRRPKSP LPYKSRDFVA LADDDSEPGV EVQKKMGKSG 

       490        500        510        520        530        540 
EREPKSVPNV RIIPSEIPAP TEGSLRSRLS TQQQTQQSVV YEDPNESIKP EESVRAPKLS 

       550        560        570        580        590        600 
VVDPQLSRKT LKPLPSLVVT DQPSKQPELP KYKGRTPYTD LEQLAQSKGY TVKQVSGDGN 

       610        620        630        640        650        660 
CLFRSVCKSI RALRGEKFTH RQLRQMVVDY LRENPEFLQV YLEYVARQRD NSLPSTEQYL 

       670        680        690        700        710        720 
SEMSKCGTWG DLICLKTLSE ILKVQFNLLI LNTKQFQMVS SQDDYPDVIP LGYIDNYHYT 

       730        740        750        760        770        780 
SLVPIGLDSK GGAASSTTTG LKQLDGPRPP ITLIPESQVP AVAATISTQQ PPSIVAPPIS 

       790        800        810        820        830        840 
VGGSQLVPSI VPQPQMPKPD FKPVKPLSNL NELLDLMDRV KPQVYNDISQ LEKARQSIKV 


SLGL 

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References

[1]"Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)."
Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L.
J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ643392 Genomic DNA. Translation: ABF82114.1.
RefSeqYP_654656.1. NC_008187.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4156295.

Phylogenomic databases

ProtClustDBCLSP2511671.

Family and domain databases

InterProIPR003323. OTU.
IPR011112. Rho_N.
[Graphical view]
PfamPF02338. OTU. 1 hit.
PF07498. Rho_N. 1 hit.
[Graphical view]
SMARTSM00959. Rho_N. 3 hits.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVF232_IIV3
AccessionPrimary (citable) accession number: Q196X6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families