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Protein

Probable matrix metalloproteinase 095L

Gene

IIV3-095L

Organism
Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable endopeptidase.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Zinc; in inhibited formBy similarity1
Metal bindingi275Zinc; catalyticPROSITE-ProRule annotation1
Active sitei276PROSITE-ProRule annotation1
Metal bindingi279Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi285Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable matrix metalloproteinase 095L (EC:3.4.24.-)
Gene namesi
ORF Names:IIV3-095L
OrganismiInvertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)
Taxonomic identifieri345201 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeBetairidovirinaeChloriridovirus
Virus hostiAedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]
Proteomesi
  • UP000001358 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000037751226 – 126Activation peptideBy similarityAdd BLAST101
ChainiPRO_0000377513127 – 363Probable matrix metalloproteinase 095LAdd BLAST237

Keywords - PTMi

Zymogen

PTM databases

SwissPalmiQ196W5.

Structurei

3D structure databases

ProteinModelPortaliQ196W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi117 – 124Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi133 – 139Poly-Arg7

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090001B3.

Family and domain databases

CDDicd04278. ZnMc_MMP. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom_sf.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR036365. PGBD-like_sf.
PfamiView protein in Pfam
PF00413. Peptidase_M10. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q196W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDSFTSRL AVVMTAVVLV WWAQALPVPS PRRGESDCDA ACRKFLLQYG
60 70 80 90 100
YLDLGEENCT EVDSNRKLCS VDDELVGVPR PLARVDLAAG VSHLQTMAGL
110 120 130 140 150
EPTGRIDAST ARLFTSPRCG VPDVSKYIVA AGRRRRTRRE SVIVCTTRWT
160 170 180 190 200
TTKSNSNETL VKWWLDQSSM QWLNSTLNWV SLTNVLHHSF WKWSKESMLA
210 220 230 240 250
FQQVSLERDA QIVVRFENGS HGDGWDFDGP GNVLAHAFQP GQSLGGDIHL
260 270 280 290 300
DAAEPWTIYD IDGHDGNSIL HVVLHEIGHA LGLEHSRDPT SIMYAWYTPF
310 320 330 340 350
KYDLGPEDVS AVAGLYGAKP ASSVAAWNPK IQKFYWDRHV RNDLLPLLER
360
DLDAEEEDSD EVR
Length:363
Mass (Da):40,667
Last modified:July 11, 2006 - v1
Checksum:iBFE243A6AF604F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ643392 Genomic DNA. Translation: ABF82125.1.
RefSeqiYP_654667.1. NC_008187.1.

Genome annotation databases

GeneIDi4156239.
KEGGivg:4156239.

Entry informationi

Entry namei095L_IIV3
AccessioniPrimary (citable) accession number: Q196W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 11, 2006
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families