Reviewed, UniProtKB/Swiss-Prot Q196W4 (VF347_IIV3)

Names and origin

Protein names

Recommended name:
    Putative FAD-linked sulfhydryl oxidase 096R
    EC=1.8.3.2

Gene names

ORF Names:

IIV3-096R

Organism

Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus)

Taxonomic identifier

345201 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Chloriridovirus

Virus host

Aedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Psorophora ferox [TaxID: 7183]
Culex territans [TaxID: 42431]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Culiseta annulata [TaxID: 332058]

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	FAD By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the IIV-6 347L family. Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Virus reference strain
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Putative FAD-linked sulfhydryl oxidase 096R		PRO_0000377497
Regions
	Transmembrane	122 – 142	21	Potential
	Domain	1 – 103	103	ERV/ALR sulfhydryl oxidase
	Compositional bias	111 – 114	4	Poly-Ala
	Compositional bias	135 – 138	4	Poly-Val
Amino acid modifications
	Disulfide bond	48 ↔ 51		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q196W4-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 55AA1099C22FAB39	FASTA	148	16,744
	10 20 30 40 50 60 MSIDPKLWGN AFWSTLHHVA AGYNDHPSLG ARQVMTNFIQ SIPVLLPCAE CQDHAFDYIG 70 80 90 100 110 120 RADLDRVVSS RRQLFLFFFN FHNHVNARLN KPQLAAKTVF QRYRVPFDGE AAAATTEPPF 130 140 HWSPWLTTAL AVILVVVVAG IGHRSRFK

References

[1]	"Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)." Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L. J. Virol. 80:8439-8449(2006) [PubMed: 16912294] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ643392 Genomic DNA. Translation: ABF82126.1.
RefSeq	YP_654668.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4156240.
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit.
Pfam	PF04777. Evr1_Alr. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VF347_IIV3

Accession

Primary (citable) accession number: Q196W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	July 11, 2006
Last modified:	October 13, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)