Q196V9 (RNC_IIV3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ribonuclease 3
EC=3.1.26.3

Gene names

ORF Names:

IIV3-101R

Organism

Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) [Reference proteome]

Taxonomic identifier

345201 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Chloriridovirus

Virus host

Aedes vexans (Inland floodwater mosquito) (Culex vexans) [TaxID: 7163]
Culex territans [TaxID: 42431]
Culiseta annulata [TaxID: 332058]
Ochlerotatus sollicitans (eastern saltmarsh mosquito) [TaxID: 310513]
Ochlerotatus taeniorhynchus (Black salt marsh mosquito) (Aedes taeniorhynchus) [TaxID: 329105]
Psorophora ferox [TaxID: 7183]

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester.
Sequence similarities	Belongs to the IIV-6 142R family. Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Putative ribonuclease 3		PRO_0000376953
Regions
	Domain	81 – 208	128	RNase III
	Domain	250 – 319	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q196V9 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 721A2F2A2FD5B4C8	FASTA	333	38,408
	10 20 30 40 50 60 MLVCTNRPPV SPVLQLCRFA SNVVLFHLKI VKQIKFEFLN VFNLKIKRLQ METEVYYGPR 70 80 90 100 110 120 DDSFKDFLIK IFKLMDMGST RSETSNFLNT YINEETLPYF NMAFTSSSAN ELNNYELFEQ 130 140 150 160 170 180 MGDSTIGKFI VWSSYEKFPQ LRGKPEAVEI VARMKINLGS KDNLSQIAED LGMWTFISAT 190 200 210 220 230 240 EEARHRLKKK LLEDVFEALI GVTEYIIYEF TDTNYSQPGL AYQLVYSLLL KLFDPYILKI 250 260 270 280 290 300 DYNTLVDSKN RLKGVFDQYK DKLGLQPVYQ SERIVKNDKN VFLSKVYDGN GNFLGEGTAP 310 320 330 LKKEAEKKAS EVAILTLISN GYKKNIPSLY ETL

References

[1]	"Genome of invertebrate iridescent virus type 3 (mosquito iridescent virus)." Delhon G., Tulman E.R., Afonso C.L., Lu Z., Becnel J.J., Moser B.A., Kutish G.F., Rock D.L. J. Virol. 80:8439-8449(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ643392 Genomic DNA. Translation: ABF82131.1.
RefSeq	YP_654673.1. NC_008187.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4156245.
Phylogenomic databases
ProtClustDB	CLSP2511652.
Family and domain databases
Gene3D	1.10.1520.10. 1 hit. 3.30.160.20. 1 hit.
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like_dom. IPR000999. RNase_III_dom. [Graphical view]
Pfam	PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
PROSITE	PS50137. DS_RBD. False negative. PS00517. RNASE_3_1. False negative. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_IIV3

Accession

Primary (citable) accession number: Q196V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program