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Protein
Submitted name:

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/duck/Buleleng-Bali/04/2005(H5N1))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutininUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/duck/Buleleng-Bali/04/2005(H5N1))Imported
Taxonomic identifieri389225 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Viral envelope proteinUniRule annotation, Virion

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotation

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 127Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR008980 Capsid_hemagglutn
IPR001364 Hemagglutn_influenz_A/B
IPR000386 Hemagglutn_influenz_B
PfamiView protein in Pfam
PF00509 Hemagglutinin, 1 hit
PRINTSiPR00329 HEMAGGLUTN12
PR00331 HEMAGGLUTN2
SUPFAMiSSF49818 SSF49818, 1 hit

Sequencei

Sequence statusi: Fragment.

Q196F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IHPLTIGECP KYVKSNRLVL ATGLRNSPQR ERRRKKRGLF GAIAGFIEGG
60 70 80 90 100
WQGMVDGWYG YHHSNEQGSG YAADKESTQK AIDGVTNKVN SIIDKMNTQF
110 120 130 140 150
EAVGREFNNL ERRIENLNKK MEDGFLDVWT YNAELLVLME NERTLDFHDS
160 170 180 190 200
NVKNLYDKVR LQLRDNAKEL GNGCFEFYHK CDNECMESIR NGTYNYPQYS
210 220 230 240
EEARLKREEI SGVKLESIGT YQILSIYSTV ASSLALAIMM
Length:240
Mass (Da):27,499
Last modified:July 11, 2006 - v1
Checksum:i362A3BB048EE5F50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei240Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ644958 Viral cRNA Translation: ABG20466.1

Entry informationi

Entry nameiQ196F0_9INFA
AccessioniPrimary (citable) accession number: Q196F0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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