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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-1Imported
ORF Names:CELE_F21C3.1Imported, F21C3.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF21C3.1a; CE32387; WBGene00006656; twk-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Transmembranei128 – 16134HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20423HelicalSequence analysisAdd
BLAST
Transmembranei216 – 23823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ19671.

Expressioni

Gene expression databases

BgeeiWBGene00006656.
ExpressionAtlasiQ19671. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F21C3.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ19671.
SMRiQ19671. Positions 93-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 15276Ion_trans_2InterPro annotationAdd
BLAST
Domaini185 – 24460Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00840000131150.
HOGENOMiHOG000022169.
InParanoidiQ19671.
OMAiWIHYYGR.
PhylomeDBiQ19671.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

Q19671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFNDGDNDR IGKEEEHAGL IENQIISQKT KKQLPSWLDR PYHVWRDQFQ
60 70 80 90 100
QDKCCPKKMV KRELMFASTY VLILNVALIL YVLFGCQVFD LRHSSTNNEA
110 120 130 140 150
SFLDRALFCI TTISTIGYGN IAPFDDRGKV ICILYCVAGI PLFFMTVATN
160 170 180 190 200
SVLVVDICNI VHRSYSSQNV ENSGFRWYTS AILLAAHCFI GALIFSLFIS
210 220 230 240 250
ITTIGYGDYS PTPEGLFQYI IVTVYLCTGV ATMLLFFASL QKGIMWIHYY
260 270 280 290 300
GRKVSDSEEA EIWFGGQMMT VKDLVTLVAE KFGSTPEKLR EVLHDLDKIL
310 320 330 340 350
EVACKQAEED DDEEDWRSVN NSEALSPPAP RKKTVFLSGS SDGDDCQATI
360 370 380 390 400
HSFTSTNQRS IPKDTELAIL ALGTIQHHLR KPSVRGIHGH HHHPKIPFSK
410 420 430
PASDSNIESK EAITSLDLRK KAHRVHSDGR LLLQQDV
Length:437
Mass (Da):49,231
Last modified:March 1, 2003 - v2
Checksum:iFEFC941F2791D472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA95801.2.
PIRiT21188.
RefSeqiNP_492054.2. NM_059653.4.
UniGeneiCel.16651.

Genome annotation databases

EnsemblMetazoaiF21C3.1a.1; F21C3.1a.1; WBGene00006656.
F21C3.1a.2; F21C3.1a.2; WBGene00006656.
GeneIDi192072.
KEGGicel:CELE_F21C3.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA95801.2.
PIRiT21188.
RefSeqiNP_492054.2. NM_059653.4.
UniGeneiCel.16651.

3D structure databases

ProteinModelPortaliQ19671.
SMRiQ19671. Positions 93-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F21C3.1.2.

Proteomic databases

PaxDbiQ19671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF21C3.1a.1; F21C3.1a.1; WBGene00006656.
F21C3.1a.2; F21C3.1a.2; WBGene00006656.
GeneIDi192072.
KEGGicel:CELE_F21C3.1.

Organism-specific databases

CTDi192072.
WormBaseiF21C3.1a; CE32387; WBGene00006656; twk-1.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00840000131150.
HOGENOMiHOG000022169.
InParanoidiQ19671.
OMAiWIHYYGR.
PhylomeDBiQ19671.

Gene expression databases

BgeeiWBGene00006656.
ExpressionAtlasiQ19671. baseline.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ19671_CAEEL
AccessioniPrimary (citable) accession number: Q19671
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.