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Protein

Probable V-type proton ATPase subunit B

Gene

vha-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Required for necrotic cell death and epidermal cell fusion.By similarity2 Publications

GO - Molecular functioni

  • ATP binding Source: InterPro
  • proton-transporting ATPase activity, rotational mechanism Source: UniProtKB

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: InterPro
  • cell-cell adhesion Source: UniProtKB
  • cell death Source: UniProtKB
  • energy coupled proton transmembrane transport, against electrochemical gradient Source: UniProtKB
  • positive regulation of programmed cell death Source: WormBase
  • proton transmembrane transport Source: UniProtKB
  • regulation of intracellular pH Source: WormBase
  • regulation of syncytium formation by plasma membrane fusion Source: WormBase
  • response to hypoxia Source: WormBase

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1222556 ROS, RNS production in phagocytes
R-CEL-77387 Insulin receptor recycling
R-CEL-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.7 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable V-type proton ATPase subunit B
Short name:
V-ATPase subunit B
Alternative name(s):
Vacuolar proton pump subunit B
Gene namesi
Name:vha-12
ORF Names:F20B6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF20B6.2 ; CE04424 ; WBGene00006921 ; vha-12

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Suppression of necrotic cell death and hyperfusion of embryonic epidermal cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446311 – 491Probable V-type proton ATPase subunit BAdd BLAST491

Proteomic databases

EPDiQ19626
PaxDbiQ19626
PeptideAtlasiQ19626
PRIDEiQ19626

2D gel databases

World-2DPAGEi0020:Q19626

Expressioni

Gene expression databases

BgeeiWBGene00006921

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridi45627, 1 interactor
IntActiQ19626, 1 interactor
STRINGi6239.F20B6.2.2

Structurei

3D structure databases

ProteinModelPortaliQ19626
SMRiQ19626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00550000074724
HOGENOMiHOG000165320
InParanoidiQ19626
KOiK02147
OMAiSQGAYEN
OrthoDBiEOG091G04TR
PhylomeDBiQ19626

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q19626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVDVNQPI TGHKSAIIRN YNTNPRLIYQ TVCGVNGPLV ILNDVKFPQF
60 70 80 90 100
SEIVKITLPD GSKRSGQVLE ISKNKAVVQV FEGTSGIDAK NTICEFTGDI
110 120 130 140 150
LRTPVSEDML GRIFNGSGKP IDKGPPVLAE DFLDINGQPI NPWSRIYPEE
160 170 180 190 200
MIQTGISAID VMNSIARGQK IPIFSASGLP HNEIAAQIVR QGGLVQLPDR
210 220 230 240 250
PHEQTNFAIV FAAMGVNMET ARFFKQDFEE NGSMENVCLF LNLANDPTIE
260 270 280 290 300
RIITPRIALT SAEFLAYQCK KHVLVVLTDM SSYAEALREV SAAREEVPGR
310 320 330 340 350
RGFPGYMYTD LATIYERAGR VEGRDGSITQ IPILTMPNDD ITHPIPDLTG
360 370 380 390 400
YITEGQIYVD RQLHNRLIYP PINVLPSLSR LMKSAIGEGM TREDHSDVSN
410 420 430 440 450
QLYACYAIGK DVQAMKAVVG EEALSSDDLL YLEFLTKFEK NFITQGHYEN
460 470 480 490
RSVFESLDIG WQLLRIFPRE MLKRIPESTL EKYYPRGGAK E
Length:491
Mass (Da):54,751
Last modified:November 1, 1997 - v1
Checksum:iEDF4D13B3BD34716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081186 Genomic DNA Translation: CCD69755.1
PIRiT34226
RefSeqiNP_508711.1, NM_076310.7
UniGeneiCel.23532

Genome annotation databases

EnsemblMetazoaiF20B6.2; F20B6.2; WBGene00006921
GeneIDi180692
KEGGicel:CELE_F20B6.2
UCSCiF20B6.2.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiVATB_CAEEL
AccessioniPrimary (citable) accession number: Q19626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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