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Protein

Probable Werner syndrome ATP-dependent helicase homolog 1

Gene

wrn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi249 – 256ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • base-excision repair Source: GO_Central
  • determination of adult lifespan Source: WormBase
  • DNA metabolic process Source: WormBase
  • DNA replication Source: GO_Central
  • double-strand break repair via homologous recombination Source: GO_Central
  • growth Source: WormBase
  • response to ionizing radiation Source: WormBase

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.12 1045

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Werner syndrome ATP-dependent helicase homolog 1 (EC:3.6.4.12)
Gene namesi
Name:wrn-1
ORF Names:F18C5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF18C5.2 ; CE31791 ; WBGene00006944 ; wrn-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002050481 – 1056Probable Werner syndrome ATP-dependent helicase homolog 1Add BLAST1056

Proteomic databases

EPDiQ19546
PaxDbiQ19546
PeptideAtlasiQ19546
PRIDEiQ19546

Expressioni

Gene expression databases

BgeeiWBGene00006944

Interactioni

Protein-protein interaction databases

BioGridi39420, 5 interactors
IntActiQ19546, 4 interactors
MINTiQ19546
STRINGi6239.F18C5.2

Structurei

3D structure databases

ProteinModelPortaliQ19546
SMRiQ19546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 2611 Publication10
Repeati28 – 3721 Publication10
Domaini236 – 406Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini427 – 583Helicase C-terminalPROSITE-ProRule annotationAdd BLAST157
Domaini806 – 886HRDCPROSITE-ProRule annotationCuratedAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 372 X 10 AA repeats of N-[ED]-E-L-P-E-T-E-P-EAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi348 – 351DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Asp4
Compositional biasi90 – 95Poly-Ser6
Compositional biasi628 – 631Poly-Ser4

Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00550000074520
HOGENOMiHOG000016918
InParanoidiQ19546
KOiK10900
OMAiNCVIMAT
OrthoDBiEOG091G0B07
PhylomeDBiQ19546

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR029491 Helicase_HTH
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF14493 HTH_40, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

Sequencei

Sequence statusi: Complete.

Q19546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISDDDDLPS TRPGSVNEEL PETEPEDNDE LPETEPESDS DKPTVTSNKT
60 70 80 90 100
ENQVADEDYD SFDDFVPSQT HTASKIPVKN KRAKKCTVES DSSSSDDSDQ
110 120 130 140 150
GDDCEFIPAC DETQEVPKIK RGYTLRTRAS VKNKCDDSWD DGIDEEDVSK
160 170 180 190 200
RSEDTLNDSF VDPEFMDSVL DNQLTIKGKK QFLDDGEFFT DRNVPQIDEA
210 220 230 240 250
TKMKWASMTS PPQEALNALN EFFGHKGFRE KQWDVVRNVL GGKDQFVLMS
260 270 280 290 300
TGYGKSVCYQ LPSLLLNSMT VVVSPLISLM NDQVTTLVSK GIDAVKLDGH
310 320 330 340 350
STQIEWDQVA NNMHRIRFIY MSPEMVTSQK GLELLTSCRK HISLLAIDEA
360 370 380 390 400
HCVSQWGHDF RNSYRHLAEI RNRSDLCNIP MIALTATATV RVRDDVIANL
410 420 430 440 450
RLRKPLITTT SFDRKNLYIS VHSSKDMAED LGLFMKTDEV KGRHFGGPTI
460 470 480 490 500
IYCQTKQMVD DVNCVLRRIG VRSAHYHAGL TKNQREKAHT DFMRDKITTI
510 520 530 540 550
VATVAFGMGI DKPDVRNVIH YGCPNNIESY YQEIGRAGRD GSPSICRVFW
560 570 580 590 600
APKDLNTIKF KLRNSQQKEE VVENLTMMLR QLELVLTTVG CRRYQLLKHF
610 620 630 640 650
DPSYAKPPTM QADCCDRCTE MLNGNQDSSS SIVDVTTESK WLFQVINEMY
660 670 680 690 700
NGKTGIGKPI EFLRGSSKED WRIKTTSQQK LFGIGKHIPD KWWKALAASL
710 720 730 740 750
RIAGYLGEVR LMQMKFGSCI TLSELGERWL LTGKEMKIDA TPILLQGKKE
760 770 780 790 800
KAAPSTVPGA SRSQSTKSST EIPTKILGAN KIREYEPANE NEQLMNLKKQ
810 820 830 840 850
EVTGLPEKID QLRSRLDDIR VGIANMHEVA PFQIVSNTVL DCFANLRPTS
860 870 880 890 900
ASNLEMIDGM SAQQKSRYGK RFVDCVVQFS KETGIATNVN ANDMIPPELI
910 920 930 940 950
SKMQKVLSDA VRRVYTEHLI SRSTAKEVAT ARGISEGTVY SYLAMAVEKG
960 970 980 990 1000
LPLHLDKLNV SRKNIAMALN AVRVHLGSNV AVLTPWVEAM GVVPDFNQLK
1010 1020 1030 1040 1050
LIRAILIYEY GLDTSENQEK PDIQSMPSTS NPSTIKTVPS TPSSSLRAPP

LKKFKL
Length:1,056
Mass (Da):118,523
Last modified:October 1, 2001 - v2
Checksum:i99C23E70D06DAA0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080970 Genomic DNA Translation: CCD68193.1
PIRiT16087
RefSeqiNP_495324.2, NM_062923.5
UniGeneiCel.7245

Genome annotation databases

EnsemblMetazoaiF18C5.2; F18C5.2; WBGene00006944
GeneIDi174081
KEGGicel:CELE_F18C5.2
UCSCiF18C5.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiWRN_CAEEL
AccessioniPrimary (citable) accession number: Q19546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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