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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

che-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Function as a motor for intraflagellar retrograde transport in chemosensory neurons. Functions in cilia biogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi115 – 1228ATPSequence analysis
Nucleotide bindingi1637 – 16448ATPSequence analysis
Nucleotide bindingi1921 – 19288ATPSequence analysis
Nucleotide bindingi2226 – 22338ATPSequence analysis
Nucleotide bindingi2565 – 25728ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • dynein light intermediate chain binding Source: WormBase
  • microtubule motor activity Source: WormBase

GO - Biological processi

  • chemosensory behavior Source: WormBase
  • cilium assembly Source: UniProtKB
  • dauer entry Source: UniProtKB
  • microtubule-based movement Source: InterPro
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: WormBase
  • nonmotile primary cilium assembly Source: WormBase
  • positive regulation of dauer larval development Source: WormBase
  • protein localization Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5620924. Intraflagellar transport.
R-CEL-6807878. COPI-mediated anterograde transport.
R-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Abnormal chemotaxis protein 3
Gene namesi
Name:che-3
ORF Names:F18C12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF18C12.1; CE32386; WBGene00000485; che-3.

Subcellular locationi

GO - Cellular componenti

  • ciliary membrane Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB-KW
  • dynein complex Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • nonmotile primary cilium Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 41714171Cytoplasmic dynein 2 heavy chain 1PRO_0000318748Add
BLAST

Proteomic databases

PaxDbiQ19542.
PRIDEiQ19542.

Expressioni

Gene expression databases

BgeeiWBGene00000485.

Interactioni

Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a heavy chain che-3 homodimer and a number of light intermediate chains.By similarity

GO - Molecular functioni

  • dynein light intermediate chain binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F18C12.1.

Structurei

3D structure databases

ProteinModelPortaliQ19542.
SMRiQ19542. Positions 1200-2071, 2178-3465, 3617-3842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 15981598StemBy similarityAdd
BLAST
Regioni1599 – 1823225AAA 1By similarityAdd
BLAST
Regioni1883 – 2100218AAA 2By similarityAdd
BLAST
Regioni2184 – 2432249AAA 3By similarityAdd
BLAST
Regioni2527 – 2767241AAA 4By similarityAdd
BLAST
Regioni2776 – 3064289StalkBy similarityAdd
BLAST
Regioni3140 – 3367228AAA 5By similarityAdd
BLAST
Regioni3575 – 3784210AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 20340Sequence analysisAdd
BLAST
Coiled coili629 – 69365Sequence analysisAdd
BLAST
Coiled coili829 – 86133Sequence analysisAdd
BLAST
Coiled coili927 – 1048122Sequence analysisAdd
BLAST
Coiled coili1354 – 138330Sequence analysisAdd
BLAST
Coiled coili2790 – 287788Sequence analysisAdd
BLAST
Coiled coili2999 – 305961Sequence analysisAdd
BLAST
Coiled coili3308 – 333629Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
HOGENOMiHOG000258250.
InParanoidiQ19542.
KOiK10414.
OMAiHSLEFAS.
OrthoDBiEOG091G0313.
PhylomeDBiQ19542.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequencei

Sequence statusi: Complete.

Q19542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSKDQRK TYFLRVASYL LGLNIVEEKL KSTEPLEIFL DSNTNLLVFS
60 70 80 90 100
RSEQKLELSN KMKSSAPSAN VFRVVFYKTQ SVPLNNDNFK SVVNVISANG
110 120 130 140 150
TLNHVFLKSV QNVFGKELTE GNNMQLIAAV NELEESLLAT VEMSGGGSLH
160 170 180 190 200
DEIRSWKGQT GKPANDYNEA FKQLQLLVET MEERSIDELS ELVECFEDTC
210 220 230 240 250
DELWNCGTPY PQNRMKMLIE YGASYLCETI TFKIDDSAIW RNDKVADQLR
260 270 280 290 300
SAIDVCDQML IIVRLLTAQT WKRNVEHTWE GDAMEMKFLN GFKDRLDEIL
310 320 330 340 350
SLKSLGGQLE ELLEERGVRE ETEKTIETAM RGMAPLAYNP FTEPNWKSRL
360 370 380 390 400
LVSERSIEGT IDRTLPILKQ RLAPANGDSQ SIVLSLEKLK SFLCRSNIKE
410 420 430 440 450
KLQHEREMFL NRLVSMLSQK NQEFNEKSLQ VDAKNFQFLT EVAARIVWIR
460 470 480 490 500
QQTSQMESIR SLSKMMLNNI SNYSAFASKL DEFIEKLQYA EKECFDDWCR
510 520 530 540 550
ETVGLIDNKN ETINLETTGK IMYLEASNRE LNVNYSDRLL RLLKEVRQLI
560 570 580 590 600
SLGFNIPSKI MSCANNGEKY YRFGVILKQI AHFYNTIDQQ MIPSQQSLML
610 620 630 640 650
EEAIAFEKLV IPRKDASNSA SKVTWNDPKQ LEEFIVQLQS AEQKLSNRNR
660 670 680 690 700
RLRNVHMELI EMVEKLMDLN IVKQNNEWKE IILKIRSKMK EEEIVHGAVK
710 720 730 740 750
NNMKPWLIHW DFQLYKALLI QYEWGIESIQ SQLSTISVSL VFADQKIQLR
760 770 780 790 800
PTIEEIRSKY YKELCRFLRI PDKFRGVQED ENSTKFYAQM IERSMHLLPT
810 820 830 840 850
VYEKAEQLMM KVETCDAIFV DWLVISQVDL EELIEENLKT AADWESQFKI
860 870 880 890 900
LKGKAREAER LPHELKFECI LVSTAGVKSA IEDAIQRLYD ALSWTLRHSI
910 920 930 940 950
STTSQSISTF LSQAIEVLNT VPQSIDEIAE ANAKHVIFAE NNRRLKEEWK
960 970 980 990 1000
VMEEQLTLLR SVAGTGMEQI DNLEQTWDRF ELMLDGHQSM IKDQVEVLKS
1010 1020 1030 1040 1050
NVETSVKGMK DEAEKLKARW EQFKPRNDAL QGDREEMLKA IQFIKEKRVQ
1060 1070 1080 1090 1100
WQQLSDGREK IEKECGQFGL EPPKMDIIDE IDEDIKQFED NWLIYEMFNN
1110 1120 1130 1140 1150
ELDTMSQEEW IVFRSKTYLF DEFLQKWMEK LKGTGSQTHM SVRLMKDVEH
1160 1170 1180 1190 1200
FKEVSSALKF CRGDVLSADH WHEMFRFLGL PRGTTIEKLK FADLLSVSKN
1210 1220 1230 1240 1250
IIENTDQLKQ LNSRAQGEVA IRDAIQELTL WAAQTEFTLA DYKHSNGQNL
1260 1270 1280 1290 1300
KIIKEWKESI NSLKDSQALL QSLKSSPYYS QFTDKTAVWE TRLADLDVFL
1310 1320 1330 1340 1350
AQMNEIQRKW IYLEPIFGRG ALPSEASRFS RVDSEYRAIL NDVSKDARLV
1360 1370 1380 1390 1400
SLCSRQSLKK SLEQIVDQLN RCQKALNQFL EQKRTAFPRF YFIGDDDLLE
1410 1420 1430 1440 1450
ILGQSTNPQV IQTHMKKLFQ GINRVQFSST GETIISMVSS EGETVPLSKA
1460 1470 1480 1490 1500
VRIVPQVESW LQELSDEMRR TLKDLTAQAV ADAQPSLAKY PSQVLCLAEE
1510 1520 1530 1540 1550
VKFSASIENN LNGSSDLNSF KSQLLEKLKA YTNMKVDDKV SDLKLKSLIL
1560 1570 1580 1590 1600
DLIHHIDVVD QLLTNQAKSI NSWTWQRQLR FYLVNGGIVL RQVSSEFEYT
1610 1620 1630 1640 1650
YEYQGNYAKL VHTPLTDKCY LTLTQAMYMG LGGNPYGPAG TGKTESVKAL
1660 1670 1680 1690 1700
AALMGRQVLV FNCDEGIDVT SMGRIFTGIV ECGAWGCFDE FNRLDSTVLS
1710 1720 1730 1740 1750
AVSMQIQTIQ GAIKSRAGSC TFGGKNVQVN PNSAIFVTLN PAGKGYGGRQ
1760 1770 1780 1790 1800
KMPDNLKQLF RAVVMGKPDN ELISSTILYS EGFVDATALA RKIVSVFQLS
1810 1820 1830 1840 1850
RQMLSKQQHY DWGLRALKVV LGGCGALRRT QTNKNETDLV VQALLLNTLS
1860 1870 1880 1890 1900
KLTFSDSERF NSLIDDIFSN VTKEMTKFEE LVEPLGVAAQ EMGIKLGDKQ
1910 1920 1930 1940 1950
MEKVFQLYEQ MRQRIGVVVV GAAGSGKSTI WKILQRSLIL TKKPLKVTQF
1960 1970 1980 1990 2000
NPKAVNRSKL LGNMDMDTRE WSDGIITMAA REVTKDTSVH HWIVCDGDID
2010 2020 2030 2040 2050
PEWVEALNSV LDDNRLLTMP SGERIQFGSN VNFLFETDSL QFASPATVSR
2060 2070 2080 2090 2100
MGMIYISEED VTPKDIVASW LVKTTEDLHA DMPSWIEEHF WRCLKWVRSH
2110 2120 2130 2140 2150
KISGITSFAI LKNGLTHLKA SKTKTQFLVL LFNGFLPTVT PENRQEFAKG
2160 2170 2180 2190 2200
VVFQGMSVPD PKNICYDERI DGIMSYTDDV SQNVTKEEVE REDLRPFVQT
2210 2220 2230 2240 2250
ADTQRYSDII GSWLQSGNRE SFLITGTTGC GKQQLLKHCF QNDPESQLAS
2260 2270 2280 2290 2300
LYCSAQSSSS HLLQLIQQNC VQASNPTGRV WRPKDRPNMI LFLKGINLPA
2310 2320 2330 2340 2350
PDKYGTNELL ALLQQLLTYQ GFFDHNLEWV SIENIQFVGS MNPIGDGAAV
2360 2370 2380 2390 2400
SISNRLFSLL RCVSLNTTDS SQLTSIYRTY LTPILEEVGE RNSEIIANRM
2410 2420 2430 2440 2450
VDIYNKVQSN FRPTDSVVFL FSPRDLTNWV VSLLRHELDQ GKLEAVICFE
2460 2470 2480 2490 2500
ARRIFADRLP TENDKLKFEE ILRNVIPISQ ANETVIFKEK VYVTTGTVVP
2510 2520 2530 2540 2550
GESNTGLPLT PINMSDFNQL LAKSINRFAF EIANFNCPLT SQLAFFCACI
2560 2570 2580 2590 2600
DRVLTGPGGH LFLPGRPGFG RRDSVRLVAH MHNIQVFSPP VTANFSAKQF
2610 2620 2630 2640 2650
DNELKNAITQ AVTNNEHVVL ILEDHQLRKN IFLQAINSLL ASGNVPGLFT
2660 2670 2680 2690 2700
QQELDGLVAL VSEAANQASF TGALQQFLAH RIRSLVHVVL ILEVEANDFK
2710 2720 2730 2740 2750
INITENPAIL KHCNVIFADR FDRNSLVEIP KIQMESQGIT TTDAILTGFN
2760 2770 2780 2790 2800
DVLVNLPEHL SIQPIKYRQF VENFFQLLGY KRLTLSVRLE RLKGGVSKLN
2810 2820 2830 2840 2850
EARDEVAKMQ KKAGKKSKLL AEKQAEADEA LKAITESMSG AEDQKLSMEQ
2860 2870 2880 2890 2900
LKAATEKENV RIEEQKAKID EQLKEVQPLI DEARRAVGSI KSESLSEIRS
2910 2920 2930 2940 2950
LRAPPEAVRD ILQAVLLFMG ILDTSWEAMR KFLSKSGVKD DIMNFDANRI
2960 2970 2980 2990 3000
TNEIHKKVTA LVKQKSNSFE EANAKRASAA AAPLAAWVKA NLEYSKILEK
3010 3020 3030 3040 3050
IAPLEGEKNK LVKNLKKAEK QMENLSKGLQ SVDEVVGELK RKFEVLMKEA
3060 3070 3080 3090 3100
TQIKVDLDRE QDTIRIAGTL VESLSGEFER WKIQIETFGE EQSKMELCSL
3110 3120 3130 3140 3150
ITSAFITYLG GCSEKDRKSL LKSMCKMFNM PPTFKPLSFA SLETEQLNWK
3160 3170 3180 3190 3200
TKGLPADQLS LENGSILFTS CHAPLIIDRS GQVSLFLSKF LEKSETFKAA
3210 3220 3230 3240 3250
QPDLMTQIEL AIRFGKTIII DDIVEFDSAL IPILRKDLSS QGPRQVISFG
3260 3270 3280 3290 3300
GKSIDFNPDF KIYFCTRDEK VDIRPNSYVQ LNIVNFTTTI SALSAQLLDV
3310 3320 3330 3340 3350
AIHLEKPELE ERSSSLLRDA ELKKLELEGL EQLLLQQLAS SQGNLLENTA
3360 3370 3380 3390 3400
LLDSLNKSKE SAEIITKSIV ESEQLHKELT TQKDIYVPLS LFTSSLFFSF
3410 3420 3430 3440 3450
SNLQFHNPMY NYSVNTIMHL FGKTIKSCED KSSTRVETLA RQMQLTVFYH
3460 3470 3480 3490 3500
ISRGIFRQDR LMFAVAFINA TMPKMFQPKE WELFTGVLVD ESTDLSALRV
3510 3520 3530 3540 3550
QWISPDRLQS LARIRTHLPS LFNNFQIQDD ATWNEFSKTL QCENAFPKNV
3560 3570 3580 3590 3600
ELKMTHFQKV LFIQAVKPER LYNCLMDFVL KTLNIPSINP PAFELKHIFQ
3610 3620 3630 3640 3650
ESESTEPILF ILADGADPSQ ELSEFASSMN VPYHSISMGQ GQEIAAYEAI
3660 3670 3680 3690 3700
RESASKGEWL CLNNLHLMLQ AVPSIFKHLS LTTPHENFRL WLTTEGDARF
3710 3720 3730 3740 3750
PSMMLQQSLK ITFEPPPGVR NNLLRTYTQI DRSTKNVITC QSIFVLAWLH
3760 3770 3780 3790 3800
ALLQERRTFI PQGWTKFYEF GASDVRVAKS FVEQLTANKA DWEFVRGILK
3810 3820 3830 3840 3850
FVIYGGRIEN DFDFKVLDSY LNVLFCDEKI NGRAGSQLVK GIDLLATTNV
3860 3870 3880 3890 3900
QEYIGHISKS VPSVDEPYLF GLPENIKYSW QIVEADRTIS SIRTLALGDT
3910 3920 3930 3940 3950
KNALSDQSDK ISQIVSLWKK LCQSDDLPKR ELPTAIRSAD PISEVLCLET
3960 3970 3980 3990 4000
INALSLIKQL HRSIGHVAKS MKTPSLASPA VQKTIQSLVF QQTPDEWDSM
4010 4020 4030 4040 4050
WAGPSDPADY LNVVVKKTRG TLQLFESSKS SSLLSSPIDF SDLFYPNIFL
4060 4070 4080 4090 4100
NALRQTTSRQ IKIPLDQLIL SSAWTPSQLP AKQCVQVQGL LLQGATFDSF
4110 4120 4130 4140 4150
LRETTVSSAA YSQAPIVFLA WTSESSSTIT GEQIQVPVYS SSERSDLICS
4160 4170
VNMPCRGADQ WNIAAVALFL R
Length:4,171
Mass (Da):473,818
Last modified:March 1, 2003 - v2
Checksum:iD45B5ADE572D06BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75536 Genomic DNA. Translation: CAA99830.2.
PIRiT21085.
RefSeqiNP_492221.2. NM_059820.2.
UniGeneiCel.18923.

Genome annotation databases

EnsemblMetazoaiF18C12.1; F18C12.1; WBGene00000485.
GeneIDi172593.
KEGGicel:CELE_F18C12.1.
UCSCiF18C12.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75536 Genomic DNA. Translation: CAA99830.2.
PIRiT21085.
RefSeqiNP_492221.2. NM_059820.2.
UniGeneiCel.18923.

3D structure databases

ProteinModelPortaliQ19542.
SMRiQ19542. Positions 1200-2071, 2178-3465, 3617-3842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F18C12.1.

Proteomic databases

PaxDbiQ19542.
PRIDEiQ19542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF18C12.1; F18C12.1; WBGene00000485.
GeneIDi172593.
KEGGicel:CELE_F18C12.1.
UCSCiF18C12.1. c. elegans.

Organism-specific databases

CTDi172593.
WormBaseiF18C12.1; CE32386; WBGene00000485; che-3.

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
HOGENOMiHOG000258250.
InParanoidiQ19542.
KOiK10414.
OMAiHSLEFAS.
OrthoDBiEOG091G0313.
PhylomeDBiQ19542.

Enzyme and pathway databases

ReactomeiR-CEL-5620924. Intraflagellar transport.
R-CEL-6807878. COPI-mediated anterograde transport.
R-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ19542.

Gene expression databases

BgeeiWBGene00000485.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDYHC2_CAEEL
AccessioniPrimary (citable) accession number: Q19542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.