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Protein
Submitted name:

TuBulin, Alpha

Gene

tba-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TuBulin, AlphaImported
Gene namesi
Name:tba-5Imported
ORF Names:CELE_F16D3.1Imported, F16D3.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF16D3.1; CE09434; WBGene00006531; tba-5.

Subcellular locationi

GO - Cellular componenti

  • axonemal microtubule Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ19490.
PaxDbiQ19490.
PRIDEiQ19490.

Interactioni

Subunit structurei

Dimer of alpha and beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi6239.F16D3.1.

Structurei

3D structure databases

ProteinModelPortaliQ19490.
SMRiQ19490. Positions 1-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 246198TubulinInterPro annotationAdd
BLAST
Domaini248 – 393146Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119060.
HOGENOMiHOG000165711.
InParanoidiQ19490.
OMAiAIQEAWA.
OrthoDBiEOG7TBC1W.
PhylomeDBiQ19490.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR013838. Beta-tubulin_BS.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVSIHIG QAGVQIGNAC WELYCLEHGI TPDGLMPDDT SYGVEDQSYN
60 70 80 90 100
TFFSETPSGK HVPRAIFVDL EPTVIDEVRT GTYAKLFHPE QLISGKEDAA
110 120 130 140 150
NNYARGHYTI GKELIDVVMD RVRRLTERCQ SLQGFLIFHS FGGGTGSGFT
160 170 180 190 200
SLVMERLSID YGKKAKLEFS IYPAPQISTS MVEPYNSLLT THTTLEHSDC
210 220 230 240 250
SFIMDNEAIY EITKVNLGVR SPTYTHLNRL LAQVVSSITA SLRFDGALNV
260 270 280 290 300
DLTEFQTNLV PYPRIHFPLV TYAPIISAEK AYHEQLSVSE ITNVCFEPGS
310 320 330 340 350
QMVKCDPRNG KYMACCLLYR GDVVPKEINS AISTIKTKRA IQFVDWCPTG
360 370 380 390 400
FKVGINYQPP TVVPGGDMAK LQRAVCMLSN TTAIQEAWAR LDHKFDLMYA
410 420 430 440
KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGVDSF DPNDEEY
Length:447
Mass (Da):50,142
Last modified:November 1, 1996 - v1
Checksum:iE7D29CB7D446D567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB01495.1.
PIRiT21017.
RefSeqiNP_492268.1. NM_059867.1.
UniGeneiCel.18930.

Genome annotation databases

EnsemblMetazoaiF16D3.1; F16D3.1; WBGene00006531.
GeneIDi184569.
KEGGicel:CELE_F16D3.1.
UCSCiF16D3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB01495.1.
PIRiT21017.
RefSeqiNP_492268.1. NM_059867.1.
UniGeneiCel.18930.

3D structure databases

ProteinModelPortaliQ19490.
SMRiQ19490. Positions 1-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F16D3.1.

Proteomic databases

EPDiQ19490.
PaxDbiQ19490.
PRIDEiQ19490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF16D3.1; F16D3.1; WBGene00006531.
GeneIDi184569.
KEGGicel:CELE_F16D3.1.
UCSCiF16D3.1. c. elegans.

Organism-specific databases

CTDi184569.
WormBaseiF16D3.1; CE09434; WBGene00006531; tba-5.

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119060.
HOGENOMiHOG000165711.
InParanoidiQ19490.
OMAiAIQEAWA.
OrthoDBiEOG7TBC1W.
PhylomeDBiQ19490.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR013838. Beta-tubulin_BS.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ19490_CAEEL
AccessioniPrimary (citable) accession number: Q19490
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.