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Protein

Hexokinase

Gene

CELE_F14B4.2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: GO_Central
  3. glucokinase activity Source: GO_Central
  4. mannokinase activity Source: GO_Central

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: GO_Central
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_273889. Regulation of gene expression in beta cells.
REACT_300789. Glucose transport.
REACT_354295. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:CELE_F14B4.2Imported, F14B4.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF14B4.2a; CE05628; WBGene00008780.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ19440.
PRIDEiQ19440.

Expressioni

Gene expression databases

ExpressionAtlasiQ19440. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_ZK829.7Q236243EBI-319585,EBI-315971

Protein-protein interaction databases

DIPiDIP-26887N.
IntActiQ19440. 1 interaction.
MINTiMINT-1129380.
STRINGi6239.F14B4.2a.2.

Structurei

3D structure databases

ProteinModelPortaliQ19440.
SMRiQ19440. Positions 37-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162670.
InParanoidiQ19440.
KOiK00844.
OMAiIKPGITF.
PhylomeDBiQ19440.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIVCHPIL DSQNGIATDA VIKKQRPPPL VLSRPKDLIQ EACQRLVLSD
60 70 80 90 100
QQLRRIMQSM EKSMEQGLAT STKKVAVKML PTYVDSVPNG TESGDFLALD
110 120 130 140 150
LGGTNFRVLH IKLQGKETKM TGKIFRVPES IMRGTGEALF DHIAGCMAKF
160 170 180 190 200
MGENDLKDAQ KLPLGFTFSF PCEQEGLTKG KLVTWTKGFK ASGVEGVDVV
210 220 230 240 250
TLLHEACHRR KDIDIDVVAL LNDTVGTLMA CAFQENSCQI GVIVGTGTNA
260 270 280 290 300
CYMERLDRIP KLAGYVDEHG VTPEEMIINT EWGAFGDDGA LDFLRTEWDE
310 320 330 340 350
VVDRESINPG QHLYEKMISG MYMGECARVV LEDLAKQGLL FGGNSDAISV
360 370 380 390 400
PHCFPTKFVS EIDSDLLEDD DRTFQKTYQI LEDIGVEMIT ANDCANVAYV
410 420 430 440 450
CSLISTRAAH LTAAGIAMLL NRMNKKHVTV GVDGSVYRFH PTYPTLLDAK
460 470 480 490 500
IGELIVGDIE YKLMLSEDGS GRGAALVAAV ATRLKEEKLA ASLSSSSSNQ
Length:500
Mass (Da):54,670
Last modified:November 1, 1996 - v1
Checksum:i446EF1799DFAFEC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA99826.1.
PIRiT20869.
RefSeqiNP_001021106.1. NM_001025935.2.
UniGeneiCel.7424.

Genome annotation databases

EnsemblMetazoaiF14B4.2a; F14B4.2a; WBGene00008780.
GeneIDi172751.
KEGGicel:CELE_F14B4.2.
UCSCiF14B4.2b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAA99826.1.
PIRiT20869.
RefSeqiNP_001021106.1. NM_001025935.2.
UniGeneiCel.7424.

3D structure databases

ProteinModelPortaliQ19440.
SMRiQ19440. Positions 37-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26887N.
IntActiQ19440. 1 interaction.
MINTiMINT-1129380.
STRINGi6239.F14B4.2a.2.

Proteomic databases

PaxDbiQ19440.
PRIDEiQ19440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF14B4.2a; F14B4.2a; WBGene00008780.
GeneIDi172751.
KEGGicel:CELE_F14B4.2.
UCSCiF14B4.2b. c. elegans.

Organism-specific databases

CTDi172751.
WormBaseiF14B4.2a; CE05628; WBGene00008780.

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162670.
InParanoidiQ19440.
KOiK00844.
OMAiIKPGITF.
PhylomeDBiQ19440.

Enzyme and pathway databases

ReactomeiREACT_273889. Regulation of gene expression in beta cells.
REACT_300789. Glucose transport.
REACT_354295. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

NextBioi876865.

Gene expression databases

ExpressionAtlasiQ19440. baseline and differential.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ19440_CAEEL
AccessioniPrimary (citable) accession number: Q19440
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.