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Protein

Mannosyl-oligosaccharide glucosidase

Gene

mogs-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor highly specifically.By similarity1 Publication

Catalytic activityi

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-CEL-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle

Protein family/group databases

CAZyiGH63 Glycoside Hydrolase Family 63

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidaseImported (EC:3.2.1.106By similarity)
Alternative name(s):
Processing A-glucosidase IBy similarity
Gene namesi
Name:mogs-1Imported
Synonyms:agl-11 Publication
ORF Names:F13H10.4Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF13H10.4a ; CE40354 ; WBGene00008775 ; mogs-1
F13H10.4b ; CE40355 ; WBGene00008775 ; mogs-1
F13H10.4c ; CE40940 ; WBGene00008775 ; mogs-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini68 – 796LumenalSequence analysisAdd BLAST729

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown reduces lifespan to less than half of that of controls. Reduced paucimannose and complex-type glycans and increased glucosylated oligomannose glycans and fucosylated N-glycans. Chronic endoplasmic reticulum stress response is believed to be due to the accumulation of triglucosylated free oligosaccharides as a result of impaired glycan processing.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577151 – 796Mannosyl-oligosaccharide glucosidaseCuratedAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi517N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ19426
PaxDbiQ19426
PeptideAtlasiQ19426
PRIDEiQ19426

PTM databases

iPTMnetiQ19426

Expressioni

Gene expression databases

BgeeiWBGene00008775

Interactioni

Protein-protein interaction databases

STRINGi6239.F13H10.4a.2

Structurei

3D structure databases

ProteinModelPortaliQ19426
SMRiQ19426
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 130Required for endoplasmic reticulum targetingBy similarityAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 8Endoplasmic reticulum targeting7

Sequence similaritiesi

Belongs to the glycosyl hydrolase 63 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2161 Eukaryota
ENOG410XTHA LUCA
GeneTreeiENSGT00390000017452
HOGENOMiHOG000201473
InParanoidiQ19426
KOiK01228
OMAiGNWQMHL
OrthoDBiEOG091G07DR
PhylomeDBiQ19426

Family and domain databases

Gene3Di1.50.10.10, 1 hit
2.70.98.110, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR031335 Glyco_hydro_63_C
IPR031631 Glyco_hydro_63N
IPR038518 Glyco_hydro_63N_sf
IPR004888 Glycoside_hydrolase_63
PANTHERiPTHR10412 PTHR10412, 1 hit
PfamiView protein in Pfam
PF03200 Glyco_hydro_63, 1 hit
PF16923 Glyco_hydro_63N, 1 hit
SUPFAMiSSF48208 SSF48208, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q19426-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHREHEEMHQ PSRRRRPPRE VERPSATIRY EPVAEPEPWC SFCSWDLILI
60 70 80 90 100
LLVMLGAGCF ILLHLYLYPN LEKVAPLPNI DPENAPYTWG TYRPHMYFGL
110 120 130 140 150
RTRSPMSPLF GMMWYEQPNT IQRPHIRHWC NQDDRLPGYY WYEADGRHFG
160 170 180 190 200
KQNISEAHKG VIQTDWINDA NGFAARVKLN MAPGRRYNVI LYLSAQEIGT
210 220 230 240 250
RFRLGKHLSD VFHGYNELLG KFTMSLRLKD NTKLQTSHSV MLTDEKIPID
260 270 280 290 300
RYHDFVVDNT QAYNAPNQPL NYILNEKHND EEGKFIAVQL NLGSQAEFDI
310 320 330 340 350
ILQTEKLKGM KPEEFTNILR IRSYNFNKKY ENVFQLAGKN YTKTQLKMAK
360 370 380 390 400
VSLSNMLGSV GYWYGHNRVL FNGIVQPYGP HVLFSAVPSR PFFPRGFLWD
410 420 430 440 450
EGFHQMLIRK MDSKMTLEAI ASWMNAMDTS GWIPREMIVG SEAEAKVPAE
460 470 480 490 500
FIPQKNDVAN PPTLFYVMDK LVNDEKTVGR YAGILKLLYP RLEKWFHWIR
510 520 530 540 550
ITQSGPTRTT YRWRGRNETI KTELNPKTLS SGLDDFPRAS HPSDLEYHLD
560 570 580 590 600
LRCWLALASR VLNRLAKSYG TDADYQRTAK AMEELNNFDS LVKDHWSEEA
610 620 630 640 650
QGFFDYGKHS FDVALSPVPT PGSPRQFEYQ RVTSRAPSYT LVSDAFGYNN
660 670 680 690 700
LFPMMLKLIP SKSPILKSML DKIRDPKILW TNYGLRSISR SSPYYMARNT
710 720 730 740 750
EHDPPYWRGY IWINVNYMVL SSLRHYADQP GPYRENAENI FSELRANLVK
760 770 780 790
NLATQFQKTG FLWENYDDRT GEGRGCHPFT GWSSLILLIM SDNLDT
Note: No experimental confirmation available.
Length:796
Mass (Da):92,646
Last modified:November 28, 2006 - v2
Checksum:iA9DB69788CBB1F09
GO
Isoform b (identifier: Q19426-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Note: No experimental confirmation available.
Show »
Length:789
Mass (Da):91,697
Checksum:i6A1A86F3F3752028
GO
Isoform cImported (identifier: Q19426-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.
     303-303: Q → HSFR

Note: No experimental confirmation available.
Show »
Length:792
Mass (Da):92,096
Checksum:iBBC7B82F261F31B0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216351 – 7Missing in isoform b and isoform c. Curated7
Alternative sequenceiVSP_057602303Q → HSFR in isoform c. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68748 Genomic DNA Translation: CAL36499.1
Z68748 Genomic DNA Translation: CAL36500.1
Z68748 Genomic DNA Translation: CAN86588.1
PIRiT20864
RefSeqiNP_001076681.1, NM_001083212.3 [Q19426-1]
NP_001076682.1, NM_001083213.3 [Q19426-2]
NP_001122771.1, NM_001129299.2 [Q19426-3]
UniGeneiCel.17548

Genome annotation databases

EnsemblMetazoaiF13H10.4a; F13H10.4a; WBGene00008775 [Q19426-1]
GeneIDi177998
KEGGicel:CELE_F13H10.4
UCSCiF13H10.4a.1 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOGS1_CAEEL
AccessioniPrimary (citable) accession number: Q19426
Secondary accession number(s): A5JYS7, Q0G829, Q0G830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health