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Protein

Yes-associated protein homolog 1

Gene

yap-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in thermal stress response and in aging.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: WormBase
  • RNA polymerase II transcription factor binding Source: WormBase

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Yes-associated protein homolog 11 Publication
Gene namesi
Name:yap-1Imported
ORF Names:F13E6.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF13E6.4; CE37348; WBGene00008748; yap-1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Cytoplasmic localization is regulated by wts-1 and ftt-2. Localizes in the cytoplasm when phosphorylated at Ser-104. Transient nuclear localization in hypodermal cells upon heat shock treatment. Nuclear export after heat shock treatment is regulated by wts-1, ftt-2, hsf-1 and daf-21. During the embryonic development of dorsal epithelial cells, localizes transiently in the nucleus. Mainly cytoplasmic during embryo elongation.1 Publication

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
  • RNA polymerase II transcription factor complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown at L1 stage results in vulva protrusion and rupture of internal tissues resulting in premature death. RNAi-mediated knockdown in middle-aged adults extends their lifespan.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104S → A: Cytoplasmic localization. No significant effect on nucleocytoplasmic localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004324741 – 442Yes-associated protein homolog 1CuratedAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ19404.
PaxDbiQ19404.
PeptideAtlasiQ19404.

PTM databases

iPTMnetiQ19404.

Expressioni

Tissue specificityi

Expressed in epithelia, hypodermis, muscles, pharynx, intestine, gonadal sheath cells, vulva, spermatheca and in excretory tissue.1 Publication

Gene expression databases

BgeeiWBGene00008748.

Interactioni

Subunit structurei

Interacts (via WW domain) with wts-1 (via N-terminus). Interacts (via WW domain) with egl-44; the interaction may regulate transcription.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: WormBase
  • RNA polymerase II transcription factor binding Source: WormBase

Protein-protein interaction databases

DIPiDIP-25866N.
IntActiQ19404. 2 interactors.
MINTiMINT-1119962.
STRINGi6239.F13E6.4.

Structurei

3D structure databases

ProteinModelPortaliQ19404.
SMRiQ19404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 236WWPROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 399Gln-richPROSITE-ProRule annotationAdd BLAST127

Sequence similaritiesi

Belongs to the YAP1 family. Highly divergent.Curated
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000017501.
InParanoidiQ19404.
KOiK16687.
OMAiHVKSVSH.
OrthoDBiEOG091G0HD4.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSIHKKH QENSQQDKNQ FSVHHYLDPN QSIHALISCS EKKYEKNQNQ
60 70 80 90 100
KKNPLPSSYY HQKRNPGSSA HSPYGSVDES SRTAVSPAMD MVSNQAPIHT
110 120 130 140 150
RQVSAPNLHT SVNNGQSSAT VPHPSHHNVH HQHSKSVSAL PMTIGYSPVP
160 170 180 190 200
SHVKSVSHEA NYSYAGLSEI PQQQGMMQQN REKSLSLDPM RRPFMTPQDV
210 220 230 240 250
EQLPMPQGWE MCYDSDGVRY FKDHNSKTTT WDDPRLKQQE QTGFGLGENI
260 270 280 290 300
GQNRYNNCYD NGHSSRSLPS IHQHQQMIPN HPQPQYSSQQ QMDYIQQLQN
310 320 330 340 350
ERMMIQEKNA QLINSGLVDS PQPPYQAISP MSSTMMHSHD PNFMYQQQQQ
360 370 380 390 400
AQNSQQQQTP HTLHQIPNQY QNSQMNDDSA MEVDYSMVSH PQQLQHQHQP
410 420 430 440
HMHNNMPSNY VIDDINPHEF DQYLQISNDN NRGVGSMVHH YQ
Length:442
Mass (Da):50,692
Last modified:November 23, 2004 - v2
Checksum:iDE2E0F058C57E190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68105 Genomic DNA. Translation: CAA92121.2.
PIRiG89632.
RefSeqiNP_509789.2. NM_077388.4.
UniGeneiCel.23550.

Genome annotation databases

EnsemblMetazoaiF13E6.4; F13E6.4; WBGene00008748.
GeneIDi181267.
KEGGicel:CELE_F13E6.4.
UCSCiF13E6.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68105 Genomic DNA. Translation: CAA92121.2.
PIRiG89632.
RefSeqiNP_509789.2. NM_077388.4.
UniGeneiCel.23550.

3D structure databases

ProteinModelPortaliQ19404.
SMRiQ19404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25866N.
IntActiQ19404. 2 interactors.
MINTiMINT-1119962.
STRINGi6239.F13E6.4.

PTM databases

iPTMnetiQ19404.

Proteomic databases

EPDiQ19404.
PaxDbiQ19404.
PeptideAtlasiQ19404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF13E6.4; F13E6.4; WBGene00008748.
GeneIDi181267.
KEGGicel:CELE_F13E6.4.
UCSCiF13E6.4. c. elegans.

Organism-specific databases

CTDi181267.
WormBaseiF13E6.4; CE37348; WBGene00008748; yap-1.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000017501.
InParanoidiQ19404.
KOiK16687.
OMAiHVKSVSH.
OrthoDBiEOG091G0HD4.

Miscellaneous databases

PROiQ19404.

Gene expression databases

BgeeiWBGene00008748.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYAP1_CAEEL
AccessioniPrimary (citable) accession number: Q19404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.