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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-38

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-38Imported
ORF Names:CELE_F11H8.2Imported, F11H8.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF11H8.2 ; CE36534 ; WBGene00017389 ; lgc-38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei257 – 281HelicalSequence analysisAdd BLAST25
Transmembranei290 – 311HelicalSequence analysisAdd BLAST22
Transmembranei323 – 345HelicalSequence analysisAdd BLAST23
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501290399516 – 459Sequence analysisAdd BLAST444

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ19358

Expressioni

Gene expression databases

BgeeiWBGene00017389

Interactioni

Protein-protein interaction databases

STRINGi6239.F11H8.2

Structurei

3D structure databases

ProteinModelPortaliQ19358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 256Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini264 – 362Neur_chan_membInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231336
InParanoidiQ19358
KOiK05181
OMAiRRHMKED
OrthoDBiEOG091G0805
PhylomeDBiQ19358

Family and domain databases

Gene3Di2.70.170.101 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 3 hits
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q19358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLLWSLLI GYVTTEHPPL MKSDKLIEYA PQASTEPTLG GESNENLENN
60 70 80 90 100
VTRLLDKLIA SHDRRIRPNY GGPPIEVNIT AHVTTISAVS EVSMDYTLDL
110 120 130 140 150
YLRQIWKDPR LAWESDVEDS LTIGIDMVKT IWTPDTFFPN EKKSFFHEAT
160 170 180 190 200
SHNSFLRIDN HGNVLRSIRL TVTANCPMSL HTFPLDRQEC ALEVESYGYS
210 220 230 240 250
TKDIIYHWHG TNAVTIDENV HLAHFTIGEH KHIERTISLS TGNYSRLTAY
260 270 280 290 300
FLFKRNIGFY LIQIYFPSSL IVVISWVSFW LNREAVQARV AIGVTTVLTM
310 320 330 340 350
TTLMTSTNAS LPKVSYVKSL DVFLGVCFFI VFASLLEYAA IGYLMKRNRS
360 370 380 390 400
VPAASPVQYY ETGDGVLKRE ASRKKSRNRR DSSMKNYQNN NIHHRPSDGH
410 420 430 440 450
VDQRIPLLSM VPMPPIPFKP QNGAWGKVRP AQVDLFSRFA FPIFFVIFHI

VYWTYYINQ
Length:459
Mass (Da):52,626
Last modified:July 5, 2004 - v3
Checksum:i812C5B81A4B1D55A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD63396.1
PIRiT16035
RefSeqiNP_498532.3, NM_066131.5
UniGeneiCel.9104

Genome annotation databases

EnsemblMetazoaiF11H8.2; F11H8.2; WBGene00017389
GeneIDi3565717
KEGGicel:CELE_F11H8.2
UCSCiF11H8.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ19358_CAEEL
AccessioniPrimary (citable) accession number: Q19358
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported