Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-38

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-38Imported
ORF Names:CELE_F11H8.2Imported, F11H8.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF11H8.2; CE36534; WBGene00017389; lgc-38.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei257 – 281HelicalSequence analysisAdd BLAST25
Transmembranei290 – 311HelicalSequence analysisAdd BLAST22
Transmembranei323 – 345HelicalSequence analysisAdd BLAST23
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ19358.

Expressioni

Gene expression databases

BgeeiWBGene00017389.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11H8.2.

Structurei

3D structure databases

ProteinModelPortaliQ19358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 256Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini264 – 362Neur_chan_membInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231336.
InParanoidiQ19358.
KOiK05181.
OMAiHHHRESI.
OrthoDBiEOG091G0805.
PhylomeDBiQ19358.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q19358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWLLWSLLI GYVTTEHPPL MKSDKLIEYA PQASTEPTLG GESNENLENN
60 70 80 90 100
VTRLLDKLIA SHDRRIRPNY GGPPIEVNIT AHVTTISAVS EVSMDYTLDL
110 120 130 140 150
YLRQIWKDPR LAWESDVEDS LTIGIDMVKT IWTPDTFFPN EKKSFFHEAT
160 170 180 190 200
SHNSFLRIDN HGNVLRSIRL TVTANCPMSL HTFPLDRQEC ALEVESYGYS
210 220 230 240 250
TKDIIYHWHG TNAVTIDENV HLAHFTIGEH KHIERTISLS TGNYSRLTAY
260 270 280 290 300
FLFKRNIGFY LIQIYFPSSL IVVISWVSFW LNREAVQARV AIGVTTVLTM
310 320 330 340 350
TTLMTSTNAS LPKVSYVKSL DVFLGVCFFI VFASLLEYAA IGYLMKRNRS
360 370 380 390 400
VPAASPVQYY ETGDGVLKRE ASRKKSRNRR DSSMKNYQNN NIHHRPSDGH
410 420 430 440 450
VDQRIPLLSM VPMPPIPFKP QNGAWGKVRP AQVDLFSRFA FPIFFVIFHI

VYWTYYINQ
Length:459
Mass (Da):52,626
Last modified:July 5, 2004 - v3
Checksum:i812C5B81A4B1D55A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD63396.1.
PIRiT16035.
RefSeqiNP_498532.3. NM_066131.5.
UniGeneiCel.9104.

Genome annotation databases

EnsemblMetazoaiF11H8.2; F11H8.2; WBGene00017389.
GeneIDi3565717.
KEGGicel:CELE_F11H8.2.
UCSCiF11H8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD63396.1.
PIRiT16035.
RefSeqiNP_498532.3. NM_066131.5.
UniGeneiCel.9104.

3D structure databases

ProteinModelPortaliQ19358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F11H8.2.

Proteomic databases

PaxDbiQ19358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11H8.2; F11H8.2; WBGene00017389.
GeneIDi3565717.
KEGGicel:CELE_F11H8.2.
UCSCiF11H8.2. c. elegans.

Organism-specific databases

CTDi3565717.
WormBaseiF11H8.2; CE36534; WBGene00017389; lgc-38.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231336.
InParanoidiQ19358.
KOiK05181.
OMAiHHHRESI.
OrthoDBiEOG091G0805.
PhylomeDBiQ19358.

Gene expression databases

BgeeiWBGene00017389.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01079. GABAARALPHA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ19358_CAEEL
AccessioniPrimary (citable) accession number: Q19358
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.