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Protein

Proton-gated ion channel subunit pbo-6

Gene

pbo-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a proton-gated ion channel with pbo-5 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Not necessary for stimulation of posterior body contraction (pBoc). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-CEL-629587 Highly sodium permeable acetylcholine nicotinic receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-gated ion channel subunit pbo-61 Publication
Alternative name(s):
PBoc defective protein pbo-61 Publication
Gene namesi
Name:pbo-6Imported
Synonyms:lgc-3Imported
ORF Names:F11C7.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF11C7.1 ; CE42343 ; WBGene00017375 ; pbo-6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 233ExtracellularSequence analysisAdd BLAST213
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 378CytoplasmicSequence analysisAdd BLAST64
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mutants exhibit normal posterior body contractions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000042414921 – 422Proton-gated ion channel subunit pbo-6Sequence analysisAdd BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi151 ↔ 165By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ19351

Expressioni

Tissue specificityi

Expressed in the posterior body muscles.1 Publication

Gene expression databases

BgeeiWBGene00017375

Interactioni

Subunit structurei

The functional channel is a hetero-oligomer of pbo-5 and pbo-6.1 Publication

Protein-protein interaction databases

STRINGi6239.F11C7.1

Structurei

3D structure databases

ProteinModelPortaliQ19351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000020771
InParanoidiQ19351
OMAiASWAYDE
OrthoDBiEOG091G07EL

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q19351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCSFLTIFI FITTVTVGVA EFSEQYQGSS SRLTRHLLEK HNKCSPPDGR
60 70 80 90 100
VDISHNIELV HIIGINELNQ NMQVLVYIVQ QWTDASLSWK VEEFRGIKHT
110 120 130 140 150
WLPEHSIWIP DIIVFNTLEH KMLLEAVRSP IKVSYTGEVT YAYPAIYTVL
160 170 180 190 200
CQIGIATFPF DDQVCKIRFA SWAYDEDKIL LNASHKPLLK NYSPNEEWAL
210 220 230 240 250
QDVDMARKEY EHEETVVSEI IYYIKVARKP FYYLISLVVP SYIICVLSIA
260 270 280 290 300
GLFARFSTKH ERQERFTLGV TAILSMAVLS LVVTEKVPHS SENVPLLIVY
310 320 330 340 350
MHFIIVMVTI ATILTSTVMR VHAKGFRTHF LSPPNWIRKV LLIARKHANF
360 370 380 390 400
FQQHGKVYMD IHTTAEQWGE VSRRMDYLLA SVFIIIISTP TLYLFYMCFQ
410 420
MDHATAERVL LENAKRRDQL YY
Length:422
Mass (Da):48,982
Last modified:January 25, 2012 - v5
Checksum:iBA042F0E33FE5700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080804, FO080802 Genomic DNA Translation: CCD66918.1
RefSeqiNP_001294833.1, NM_001307904.1

Genome annotation databases

EnsemblMetazoaiF11C7.1; F11C7.1; WBGene00017375
GeneIDi24104421
KEGGicel:CELE_F11C7.1
UCSCiF11C7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPBO6_CAEEL
AccessioniPrimary (citable) accession number: Q19351
Secondary accession number(s): G4S6G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: January 25, 2012
Last modified: May 23, 2018
This is version 136 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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